A prospective study on the safety of herbal medicines, used alone or with conventional medicines

Jeong, Tae-Young; Park, Bongki; Cho, Jung‐Hyo; Kim, Young-Il; Ahn, Yo-Chan; Son, Chang‐Gue

doi:10.1016/j.jep.2012.08.016

Cited by 48 publications

(32 citation statements)

References 23 publications

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“…However, the popularization of the use of medicinal plants, their ease of access, and lack of professional guidance on their correct use, represent a health risk (Al-Arifi, 2013;Jeong et al, 2012). This study describes a preliminary evaluation of the biological activity and safety of C. speciosa and shows that this species exhibits in vitro antioxidant potential and low toxicity, which may be related at least in part to its high concentration of polyphenols.…”

Section: Resultsmentioning

confidence: 92%

Preliminary in vitro assessment of the potential toxicity and antioxidant activity of Ceiba speciosa (A. St.-Hill) Ravenna (Paineira)

Malheiros

Silva

Hofmann

et al. 2017

Braz. J. Pharm. Sci.

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The bark tea of Ceiba speciosa, a tropical tree of the Malvaceae family, is used in the Northwestern Region of Rio Grande do Sul state, Brazil, to reduce blood cholesterol levels. However, there are no scientific data on the efficacy and safety of this plant. The aim of the present study was to evaluate the in vitro antioxidant and toxic potential of bark extracts of C. speciosa. We performed a preliminary phytochemical analysis by high-performance liquid chromatography-diode array detection (HPLC-DAD) and evaluated the oxidative damage to proteins and lipids, the radical scavenging effect, and genotoxicity of the lyophilized aqueous extract (LAECs) and the precipitate obtained from the raw ethanol extract (Cs1). The phytochemical profile demonstrated the presence of phenolic and flavonoid compounds. The LAECs and Cs1 prevented damage to lipids and proteins at concentrations of 50 and 10 µg/mL. They also showed a scavenging effect on 2,2-diphenyl-1-pricril-hydrazyl (DPPH) radicals in a concentration-dependent manner. Furthermore, no genotoxic effect was observed at concentrations of 10, 5 and 2 µg/mL in the Comet assay. The present study is the first evaluation regarding the characterization of C. speciosa and its safety, and the results demonstrate its antioxidant potential and suggest that its therapeutic use may be relatively safe.Uniterms: Ceiba speciose/phytochemistry. Ceiba speciose/antioxidant activity. Phenolic content. Comet assay. DPPH scavenging capacity. Natural medicine. Safety.

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Section: Resultsmentioning

confidence: 92%

Preliminary in vitro assessment of the potential toxicity and antioxidant activity of Ceiba speciosa (A. St.-Hill) Ravenna (Paineira)

Malheiros

Silva

Hofmann

et al. 2017

Braz. J. Pharm. Sci.

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“…So, a new approach is required for treatment of type 2 diabetes. Studies have shown that to treat and manage type 2 diabetes and its complications, several long-used herbal medicines appear to be effective (Jeong et al, 2012); for example, triterpenoids, which are a large group of compounds present in many plants (Silva et al, 2016). These compounds divide into lupane, oleonane and ursane groups (Jager et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Anti-diabetic effect of betulinic acid on streptozotocin-nicotinamide induced diabetic male mouse model

Birgani

Ahangarpour

Khorsandi

et al. 2018

Braz. J. Pharm. Sci.

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Diabetes is a metabolic disease caused by abnormal insulin secretion or action. In the present study, the effects of betulinic acid (BA, a triterpene) are evaluated on glucose, α-amylase and plasma insulin levels, insulin resistance and the histopathology of pancreatic islets in streptozotocin-nicotinamide (STZ-NA) diabetic mice. Seventy adult male NMRI mice were randomly divided into seven groups: control, sham, diabetic, diabetic treated with BA (10, 20 and 40 mg/kg) and diabetic treated with metformin (200 mg/kg). Diabetes was induced in mice by intraperitoneal injection of streptozotocin 50 mg/kg after a dose of nicotinamide 120 mg/kg. Two weeks after treatment with BA, blood samples were collected for measuring glucose, α-amylase and insulin levels, and the pancreas was isolated for histopathology evaluation. Diabetes reduced the number and diameter of pancreatic islets, and increased α-amylase and insulin resistance. BA treatment reduced blood glucose, α-amylase and improved insulin sensitivity as well as pancreas histopathology. In addition, BA showed stronger effects on the pancreatic histology and insulin resistance compared to the metformin group.

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“…Herbal medicines have been used for thousands of years in many ethnic cultures such as Chinese, Korean, Indian, and Mexican to treat and manage diabetes and its complications (Li et al, 2004;Andrade-Cetto and Heinrich, 2005;Mukherjee et al, 2006;Jeong et al, 2012). In the last few decades, modern science has uncovered the benefits of using herbal medicines in the management of particular diabetic complications, such as vascular inflammation, nephropathy, and retinopathy.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of 29-norcycloartane triterpenoids as α-glucosidase inhibitors

et al. 2014

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A series of oxygen and nitrogen derivatives of 29-norcycloartane triterpenoids have been synthesized on the basis of cyclomusalenone isolated from Musa balbisiana Colla. The structures of new compounds have been established by an NMR spectroscopy analysis, and inhibitory activity against a-glucosidase was evaluated. Among tested compounds, 2,3-isoxazolocyclomusalenone is discovered as a new potent a-glucosidase inhibitor with IC 50 value 20.4 lM being 30-and 20-fold more active than initial cyclomusalenone and marketed drug acarbose.

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A prospective study on the safety of herbal medicines, used alone or with conventional medicines

Cited by 48 publications

References 23 publications

Preliminary in vitro assessment of the potential toxicity and antioxidant activity of Ceiba speciosa (A. St.-Hill) Ravenna (Paineira)

Preliminary in vitro assessment of the potential toxicity and antioxidant activity of Ceiba speciosa (A. St.-Hill) Ravenna (Paineira)

Anti-diabetic effect of betulinic acid on streptozotocin-nicotinamide induced diabetic male mouse model

Synthesis and evaluation of 29-norcycloartane triterpenoids as α-glucosidase inhibitors

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