A prospective study on the role of CXCL13 in Lyme neuroborreliosis

Schmidt, Caroline; Plate, Andreas; Angele, Barbara; Pfister, H.-W.; Wick, Manfred; Koedel, Uwe; Rupprecht, Tobias A.

doi:10.1212/wnl.0b013e318211c39a

Cited by 124 publications

(112 citation statements)

References 20 publications

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“…However, multivariate multinomial logistic regression revealed that only CXCL13 significantly distinguished between clinically suspected and clinically evident Lyme neuroborreliosis (Table 3), but the odds ratio of 0.91 and 95% confidence interval (0.86 to 0.97) being close to 1 indicated the limited distinctive power of this marker. While our results corroborate previous findings that CXCL13 CSF concentration is the most useful diagnostic marker for Lyme neuroborreliosis (11,14,17,29), they show that it has a limited distinctive value.…”

Section: Discussionsupporting

confidence: 90%

Diagnostic Value of Cytokines and Chemokines in Lyme Neuroborreliosis

Cerar

Ogrinc

Lotrič‐Furlan

et al. 2013

Clin. Vaccine Immunol.

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The aims of the present study were to assess the concentrations of different cytokines and chemokines in blood serum and cerebrospinal fluid (CSF) samples of patients with Lyme neuroborreliosis and to identify the possible marker(s) that would enable a distinction between clinically evident and suspected Lyme neuroborreliosis, as well as between Lyme neuroborreliosis and tickborne encephalitis (TBE). Our additional interest was to evaluate the relationship between cytokine and chemokine concentrations and Borrelia burgdorferi sensu lato isolation from CSF, as well as intrathecal synthesis of specific borrelial antibodies. We found that higher concentrations of CXCL13 and lower concentrations of interleukin 10 (IL-10) in serum were associated with higher odds for clinically evident Lyme neuroborreliosis compared to suspected Lyme neuroborreliosis, as well as to TBE. The concentrations of IL-2, IL-5, IL-6, IL-10, and CXCL13 in the CSF were higher in patients with evident Lyme neuroborreliosis than in those who were only suspected to have the disease. A comparison of CSF cytokine and chemokine levels in patients with and without intrathecal synthesis of specific borrelial antibodies revealed that CXCL13 CSF concentration is significantly associated with intrathecal synthesis of borrelial antibodies. A comparison of the cytokine and chemokine CSF concentrations in patients with clinically evident Lyme neuroborreliosis according to CSF culture results revealed that higher concentrations of gamma interferon (IFN-␥) were associated with lower odds of Borrelia isolation. Although several differences in the blood serum and CSF concentrations of various cytokines and chemokines between the groups were found, the distinctive power of the majority of these findings is low. Further research on well-defined groups of patients is needed to appraise the potential diagnostic usefulness of these concentrations.

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Section: Discussionsupporting

confidence: 90%

Diagnostic Value of Cytokines and Chemokines in Lyme Neuroborreliosis

Cerar

Ogrinc

Lotrič‐Furlan

et al. 2013

Clin. Vaccine Immunol.

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“…They could be produced locally in the CNS or originate in the peripheral nervous system (PNS), especially in patients with BBB impairment [7,8,23].…”

Section: Discussionmentioning

confidence: 99%

“…Current studies have revealed that the CSF CXCL13 chemokine levels in patients with LNB correlate with pleocytosis and decrease after the initiation of antibiotic treatment [6,7].…”

Section: Introductionmentioning

confidence: 99%

CXCL13 levels are more increased in cerebrospinal fluid and plasma of patients with acute infectious than in non-infectious diseases of the central nervous system

Ţilea

Voidăzan

Bălaşa

et al. 2017

Revista Romana De Medicina De Laborator

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“…For that reason, PCR is not recommended for routine testing of CSF in Lyme disease CXCL13 -Although elevated concentrations of CXCL13, the chemokine B lymphocyte chemoattractant, are not unique to active nervous system Lyme disease, when combined with other diagnostic information, they might serve as a marker of disease activity or response to treatment (42). Like patients with neurosyphilis (43), patients with acute untreated nervous system Lyme disease and a CSF pleocytosis have elevated CSF concentrations of CXCL13 (44). Among 17 such patients, concentrations of CXCL13 were proportionately greater in CSF than in serum and were highly elevated in all CSF samples compared with the CSF of 178 controls without nervous system Lyme disease (mean 15,149 pg/mL versus 247 pg/mL) (44).…”

Section: Approach To Diagnostic Confirmationmentioning

confidence: 99%

“…Like patients with neurosyphilis (43), patients with acute untreated nervous system Lyme disease and a CSF pleocytosis have elevated CSF concentrations of CXCL13 (44). Among 17 such patients, concentrations of CXCL13 were proportionately greater in CSF than in serum and were highly elevated in all CSF samples compared with the CSF of 178 controls without nervous system Lyme disease (mean 15,149 pg/mL versus 247 pg/mL) (44). Five patients who had received at least two weeks of treatment for nervous system Lyme disease did not have substantially elevated CXCL13 concentrations (mean 202 pg/mL), whereas five patients who had been treated for less than two weeks had slightly elevated CXCL13 concentrations (mean 1412 pg/mL).…”

Section: Approach To Diagnostic Confirmationmentioning

confidence: 99%