A prospective study on symptom generation according to spicy food intake and <scp>TRPV</scp>1 genotypes in functional dyspepsia patients

Lee, S.-Y.; Masaoka, Tatsuhiro; Han, Hye Seung; Matsuzaki, Juntaro; Hong, Mi Jin; Fukuhara, Seiichiro; Choi, Heejung; Suzuki, Hidekazu

doi:10.1111/nmo.12841

Cited by 22 publications

(19 citation statements)

References 21 publications

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“…Before endoscopic examination, subjects were asked to score their symptoms from 0 (none) to 5 (very severe) on the 20-item Patient Assessment of Gastrointestinal Disorders Symptom Severity Index (PAGI-SYM) questionnaire, as described previously [16]. Endoscopic procedures were performed by one gastroenterologist (Dr. S.-Y.…”

Section: Methodsmentioning

confidence: 99%

Correlations of the Gastric and Duodenal Microbiota with Histological, Endoscopic, and Symptomatic Gastritis

Han

Lee

et al. 2019

JCM

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Mucosal inflammation is characterized by neutrophil and mononuclear cell infiltration. This study aimed to determine the gastric and duodenal microbiota associated with histological, endoscopic, and symptomatic gastritis. Dyspeptic adults who presented for evaluation were included. Subjects with either comorbidities or recent drug intake were excluded. Three endoscopic biopsies were obtained from the antrum, body, and duodenum. Next-generation sequencing for 16S ribosomal RNA V1–V2 hypervariable regions was performed. The correlation between the composition of microbiota and the degree of inflammatory cell infiltration, endoscopic findings, and Patient Assessment of Gastrointestinal Disorders Symptom Severity Index (PAGI-SYM) score was analyzed. In 98 included subjects, microbial communities in the antrum and body showed Bray–Curtis similarity; however, those in the duodenum showed dissimilarity. Histological and endoscopic gastritis was associated with the abundance of Helicobacter pylori and that of commensal bacteria in the stomach. The abundances of Variovorax paradoxus and Porphyromonas gingivalis were correlated with histological gastritis, but not with endoscopic or symptomatic gastritis. The total PAGI-SYM score showed a stronger correlation with the duodenal microbiota (Prevotella nanceiensis and Alloprevotella rava) than with the gastric microbiota (H. pylori, Neisseria elongate, and Corynebacterium segmentosum). Different correlations of the gastric and duodenal microbiota with histological, endoscopic, and symptomatic gastritis were observed for the first time at the species level. H. pylori-negative gastritis is not associated with endoscopic or symptomatic gastritis. Only H. pylori-induced endoscopic gastritis requires gastric cancer surveillance. Owing to the weak correlation with H. pylori, symptomatic gastritis should be assessed separately from histological and endoscopic gastritis.

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Section: Methodsmentioning

confidence: 99%

Correlations of the Gastric and Duodenal Microbiota with Histological, Endoscopic, and Symptomatic Gastritis

Han

Lee

et al. 2019

JCM

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“…TRPV1 is expressed in the nodose ganglia (Kentish et al, 2015 ) and activation of TRPV1 increases gastric vagal afferent excitability thereby signaling satiety whereas inhibition of TRPV1 does the converse (Bielefeldt and Davis, 2008 ). Capsaicin reduces food intake in humans (Yoshioka et al, 2001 ) and consumption of spicy capsaicin containing food was positively associated with scores of stomach fullness in functional dyspepsia patients (Lee et al, 2016 ). Further, there is hypersensitivity to capsaicin in patients with functional dyspepsia compared to healthy controls (Hammer et al, 2008 ).…”

Section: Functional Dyspepsia and Vagal Afferent Signalingmentioning

confidence: 99%

Meal-Sensing Signaling Pathways in Functional Dyspepsia

Page

2018

Front. Syst. Neurosci.

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The upper gastrointestinal tract plays an important role in sensing the arrival, amount and chemical composition of a meal. Ingestion of a meal triggers a number of sensory signals in the gastrointestinal tract. These include the response to mechanical stimulation (e.g., gastric distension), from the presence of food in the gut, and the interaction of various dietary nutrients with specific “taste” receptors on specialized enteroendocrine cells in the small intestine culminating in the release of gut hormones. These signals are then transmitted to the brain where they contribute to food intake regulation by modulating appetite as well as feedback control of gastrointestinal functions (e.g., gut motility). There is evidence that the sensitivity to these food related stimuli is abnormally enhanced in functional dyspepsia leading to symptoms such nausea and bloating. In addition, these gut-brain signals can modulate the signaling pathways involved in visceral pain. This review will discuss the role of gut-brain signals in appetite regulation and the role dysregulation of this system play in functional dyspepsia.

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“…Following the screening on title and abstract, 140 articles remained for full text screening. Forty articles met the inclusion criteria and were included in this systematic review (Figure 1) [21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60]. Reasons for the exclusion of the other 100 articles are also shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

The Alignment of Dietary Intake and Symptom-Reporting Capture Periods in Studies Assessing Associations between Food and Functional Gastrointestinal Disorder Symptoms: A Systematic Review

et al. 2019

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Food ingestion is heavily implicated in inducing symptoms of irritable bowel syndrome (IBS) and functional dyspepsia (FD), which affect over one-third of adults in developed countries. The primary aim of this paper was to assess the alignment of dietary assessment and symptom-reporting capture periods in diet-related studies on IBS or FD in adults. Secondary aims were to compare the degree of alignment, validity of symptom-reporting tools and reported significant associations between food ingestion and symptoms. A five-database systematic literature search resulted in 40 included studies, from which data were extracted and collated. The food/diet and symptom capture periods matched exactly in 60% (n = 24/40) of studies, overlapped in 30% (n = 12/40) of studies and were not aligned in 10% (n = 4/40) of studies. Only 30% (n = 12/40) of studies that reported a significant association between food and global gastrointestinal symptoms used a validated symptom-reporting tool. Of the thirty (75%) studies that reported at least one significant association between individual gastrointestinal symptoms and dietary intake, only four (13%) used a validated symptom tool. Guidelines to ensure that validated symptom-reporting tools are matched with fit-for-purpose dietary assessment methods are needed to minimise discrepancies in the alignment of food and symptom tools, in order to progress functional gastrointestinal disorder research.

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A prospective study on symptom generation according to spicy food intake and TRPV1 genotypes in functional dyspepsia patients

Abstract: Upper gastrointestinal symptoms are more common in subjects with a higher consumption of spicy foods, younger age and female gender, regardless of TRPV1 genotypes and the H. pylori infection status. Capsaicin-rich foods may induce stomach fullness.

Cited by 22 publications

References 21 publications

Correlations of the Gastric and Duodenal Microbiota with Histological, Endoscopic, and Symptomatic Gastritis

Correlations of the Gastric and Duodenal Microbiota with Histological, Endoscopic, and Symptomatic Gastritis

Meal-Sensing Signaling Pathways in Functional Dyspepsia

The Alignment of Dietary Intake and Symptom-Reporting Capture Periods in Studies Assessing Associations between Food and Functional Gastrointestinal Disorder Symptoms: A Systematic Review

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