A prospective study of vertical transmission of HIV-2 in Bissau, Guinea-Bissau Per-Ake

Dias, Francisco; Nauclkrt, Anders; Anderssont, Soren; Biberfeldt, Gunnel

doi:10.1097/00002030-199307000-00013

Cited by 79 publications

(3 citation statements)

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“…The vertical transmission of HIV-2 is rare and can occur during pregnancy, at the time of delivery, or through breastfeeding (3,14). However, the vertical route is less efficient for the transmission of HIV-2 compared to HIV-1, so that less than 2% of the children of HIV-2 seropositive mothers acquire the infection (14,(24)(25)(26)(27)(28). The lower viremia seen in HIV-2 carriers compared to that observed in HIV-l-infected persons could explain this lower rate of transmission (3,14,29,30).…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of HIV-2 infection in Spain

Soriano

Gutiérrez

Caballero

et al. 1996

Eur. J. Clin. Microbiol. Infect. Dis.

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Human immunodeficiency virus type 2 (HIV-2) infection is endemic in West Africa, where it is responsible for many cases of AIDS. HIV-2-infected subjects have been described in other countries, mainly African immigrants, although infection in native individuals has been reported as well. The first cases of HIV-2 infection in Spain were identified in 1988. Through December 1995, 56 HIV-2 infected individuals have been diagnosed, primarily in large urban areas (23 cases in Madrid and 18 in Barcelona). All are African immigrants, except for 12 natives (21.4%), six of whom acquired the infection in endemic areas; the remaining six (2 women with numerous sexual partners and 4 homo/bisexual men) acquired the infection in Spain. Heterosexual transmission was probable in all but seven cases: five homo/bisexual males, a subject who likely acquired infection through parenteral exposure, and a child born to an HIV-2-infected mother. Nine patients (all Spanish born) have developed AIDS (16%), six of whom have died. In conclusion, HIV-2 infection is present in Spain at a low rate, and there is little evidence supporting an emerging ongoing transmission outside the population of African immigrants.

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Section: Discussionmentioning

confidence: 99%

Epidemiology of HIV-2 infection in Spain

Soriano

Gutiérrez

Caballero

et al. 1996

Eur. J. Clin. Microbiol. Infect. Dis.

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“…IV-2 is characterized by less efficient transmission through the sexual and vertical routes than HIV-1 (1,2) and by a slower natural clinical course (2-4); nevertheless, HIV-2 infection eventually leads to AIDS. HIV-2 infection must be distinguished from HIV-1 infection, as HIV-2 is naturally resistant to nonnucleoside reverse transcriptase inhibitors, T20, and some protease inhibitors, and as patient follow-up differs from that of HIV-1 infection (5,6).…”

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confidence: 99%

New Sensitive One-Step Real-Time Duplex PCR Method for Group A and B HIV-2 RNA Load

et al. 2014

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. Analytic performances were determined in three laboratories. Clinical performances were evaluated on 100 plasma samples from HIV-2-infected patients (groups A, B, and H) by comparison with the assay currently used for the ANRS HIV-2 cohort. The specificity was 100%. Sensitivity was 50 copies/ml (cp/ml) and was optimized to 10 cp/ml. The within-run coefficients of variation in the three laboratories varied from 0.54% to 1.61% at 4 log 10 copies/ml and from 7.24% to 14.32% at 2 log 10 cp/ml. The between-run coefficients of variation varied from 2.28% to 6.43%. Of the 39 clinical samples below 2 log 10 in the current assay, the new test improved the detection or quantification of 17 samples, including eight group B samples. For quantifiable samples, similar loads were obtained with the two assays for group A samples. The median difference between the two assays for group B samples was ؉0.18 but with greater heterogeneity than for group A. The HIV-2 group H sample had similar results with the two assays. This new assay is highly sensitive and accurately quantifies the most prevalent HIV-2 groups. This test will be useful for monitoring low viral loads in HIV-2-infected patients.

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“…In addition, we obtained information from abstracts from AIDS and Nutrition conferences since 1997. This review will only consider transmission of HIV‐1 (subsequently referred to as HIV) because mother‐to‐child transmission (MTCT) of HIV‐2, through any route, is rare (1).…”

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confidence: 99%