A Prospective Study of the Timing and Cost-Effectiveness of Bronchial Washing During Bronchoscopy for Pulmonary Malignant Tumors

Drift, Miep A. van der; Wilt, Gert Jan van der; Thunnissen, Erik; Janssen, J.

doi:10.1378/chest.128.1.394

Cited by 76 publications

(89 citation statements)

References 15 publications

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“…Bronchial washing can be performed prior to or following biopsy sampling [38,39]. It is recommended that as much volume of washings as possible should be recovered after instilling 20-30 ml of isotonic saline [39,40].…”

Section: Exfoliative Cytologymentioning

confidence: 99%

“…It is recommended that as much volume of washings as possible should be recovered after instilling 20-30 ml of isotonic saline [39,40]. Following centrifugation the sediment can be directly stained; alternatively, fixation methods can be utilised [13,41].…”

Section: Exfoliative Cytologymentioning

confidence: 99%

“…Bronchial lavage has well-standardised guidelines and increases the diagnostic yield in peripheral pulmonary lesions [42,43]. Bronchial brushing can be performed before or after biopsy sampling and the area should be brushed two or three times [39,44]. It is particularly useful in endoscopically visible tumours [13].…”

Section: Exfoliative Cytologymentioning

confidence: 99%

See 2 more Smart Citations

Diagnosis and Predictive Molecular Analysis of Non–Small-Cell Lung Cancer in the Africa-Middle East Region: Challenges and Strategies for Improvement

Slavík

Asselah

Fakhruddin

et al. 2014

Clinical Lung Cancer

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Identification of tumour biomarkers provides information on prognosis and guides the implementation of appropriate treatment in patients with many different types of cancer. In nonsmall-cell lung cancer (NSCLC), targeted treatment plans based on biomarker identification are already being utilised in the clinic. However, such predictive molecular testing is not currently a universally employed practice. This is particularly the case in developing countries where lung cancer is increasingly prevalent. In September 2012 and November 2013, a committee of 16 lung cancer experts from Africa and the Middle East met to discuss key issues related to diagnosis and biomarker testing in NSCLC and the implementation of personalised medicine in the region. The committee identified current challenges for effective diagnosis and predictive analysis in Africa and the Middle East. Moreover, strategies to encourage the implementation of biomarker testing were discussed.Ultimately, a practical approach for the effective diagnosis and predictive molecular testing of NSCLC in these regions was derived. Key issues and recommendations arising from the meetings are presented here.Abstract word count: 167 (journal limit: 250)

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Section: Exfoliative Cytologymentioning

confidence: 99%

Section: Exfoliative Cytologymentioning

confidence: 99%

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Diagnosis and Predictive Molecular Analysis of Non–Small-Cell Lung Cancer in the Africa-Middle East Region: Challenges and Strategies for Improvement

Slavík

Asselah

Fakhruddin

et al. 2014

Clinical Lung Cancer

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“…The title indicated a cost-effectiveness analysis, but the study was actually a cost-minimisation analysis of the addition of washing or brushing to biopsy (117). The study recommended a combination of biopsy and brushing or washing for visible lesions.…”

Section: Predictors Of a Higher Diagnostic Yield In Bronchoscopymentioning

confidence: 99%

A randomised trial of endobronchial ultrasound guided sampling in peripheral lung lesions

Roth¹,

Eagan²,

Andreassen³

et al. 2011

Lung Cancer

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“…Often, BL/BAL, brushings, and forceps biopsies (FB) are combined to increase the sensitivity and a cytohistological diagnosis can be obtained in most cases [12,13]. The usefulness of obtaining washings is still a matter of controversy because the reported sensitivities are quite low [12,14].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Diagnostic Accuracy of Bronchoalveolar Lavage Cytology in the Diagnosis of Lung Tumors and Contribution to the Classification of Non-Small Cell Lung Cancer Entities: A Retrospective Clinocopathological Study

Zimpfer¹,

Polak²,

Bier³

et al. 2013

OJPathology

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Background: Due to new therapeutic options in thoracic oncology, the pathological diagnosis of bronchial carcinoma has become more challenging. The majority of bronchial cancer is diagnosed from small biopsy specimens and the diagnosis often based on cytological methods. Aims: In this study, we reevaluated cytologic specimens in order to determine the diagnostic reliability of pulmonary cytopathologic techniques performed in our department. Material and methods: In our center bronchial lavage/bronchoalveolar lavage (BL/BAL) specimens are obtained both before and after forceps biopsy (FB) and subsequently processed. Retrospective data from a period of 60 months were retrieved from the institutional files. Sensitivity, specificity, as well as accuracy of cytological tumor typing were determined using histopathology of FB as gold standard. Also, the diagnostic yield of BL/BAL before and after FB was determined. Results: 678 cases were retrieved from the institutional files. The sensitivity and specificity of cytology were 83.0% and 83.4%, respectively. By FB in 3.9% of cytologically diagnosed non-small cell lung carcinomas (NSCLC) a histological assignment to a NSCLC entity was not possible. Conclusions: Cytology is a reliable diagnostic tool in the diagnosis of lung malignancies. High diagnostic accuracy is achieved by a combination of BL/BAL before and after FB. The diagnostic yield of BL/BAL after FB was significantly higher than BL/BAL before FB. Subsequent tumor typing of cytologically diagnosed NSCLC was feasible in more than 95% of cases.

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A Prospective Study of the Timing and Cost-Effectiveness of Bronchial Washing During Bronchoscopy for Pulmonary Malignant Tumors

Cited by 76 publications

References 15 publications

Diagnosis and Predictive Molecular Analysis of Non–Small-Cell Lung Cancer in the Africa-Middle East Region: Challenges and Strategies for Improvement

Diagnosis and Predictive Molecular Analysis of Non–Small-Cell Lung Cancer in the Africa-Middle East Region: Challenges and Strategies for Improvement

A randomised trial of endobronchial ultrasound guided sampling in peripheral lung lesions

Assessment of Diagnostic Accuracy of Bronchoalveolar Lavage Cytology in the Diagnosis of Lung Tumors and Contribution to the Classification of Non-Small Cell Lung Cancer Entities: A Retrospective Clinocopathological Study

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