ObjectiveChronic subjective tinnitus is a worldwide intractable problem. In our previous studies, customized music therapy combined with a follow‐up system can reduce tinnitus perception and improve anxiety/depression. This study aims to explore which characteristics of tinnitus patients are more likely to benefit from our therapy.Study DesignThis study included 1031 patients with chronic subjective tinnitus, all of whom completed customized music therapy with the follow‐up system. Population demographics, tinnitus characteristics, and tinnitus‐related scales at pretherapy and posttherapy were collected.SettingHuadong Hospital affiliated Fudan University, Department of Otorhinolaryngology–Head & Neck Surgery from 2018 to 2022.MethodsA paired t test and the one‐way analysis of variance were utilized to the overall efficacy and stratified difference based on tinnitus duration/age/tinnitus frequency.ResultsThere were significant statistical differences in the Tinnitus Handicap Inventory (THI), Tinnitus Loudness Visual Analog Scale (VAS), and Hospital Anxiety and Depression Scale (HADS)‐A/D scores between pretherapy and 3 months posttherapy. THI and HADS (A/D) scores decreased the most in the 1‐year duration tinnitus group. The most significant decrease in THI and VAS scores was observed in the 31‐ to 50‐year‐old tinnitus group. Patients with high‐frequency tinnitus and extended high‐frequency tinnitus had greater decreases generally than those with low‐frequency tinnitus though no significance.ConclusionGroup with severe and prolonged tinnitus, shorter duration of tinnitus onset, and 31 to 50 years old benefit more from our therapy. Therefore, standardized personalized music and consulting and follow‐up systems while promoting early treatment can reduce tinnitus and its comorbidities.