A prospective study of screening for hypertensive disorders of pregnancy at 11–13 weeks in a Scandinavian population

Skråstad, Ragnhild Bergene; Hov, Gunhild Garmo; Blaas, Harm-Gerd K.; Romundstad, Pål Richard; Salvesen, Kjell Å.

doi:10.1111/aogs.12479

Cited by 21 publications

(21 citation statements)

References 34 publications

(34 reference statements)

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“…In our cohort, 96% of babies were born fullterm, and there was only one early preterm birth (1/27 baby born, 3.7%). We did not observe any increase in the rate of complications, such as pregnancy-related hypertensive disorders or gestational diabetes, as compared with the general Finnish and Nordic population [26,27]. Maternal BMI was increased before pregnancy and an average weight gain during pregnancy was 8.4 kg.…”

Section: Discussioncontrasting

confidence: 61%

Outcomes of 42 pregnancies in 14 women with cartilage-hair hypoplasia: a retrospective cohort study

Holopainen

Vakkilainen

Mäkitie

2020

Preprint

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Background Cartilage-hair hypoplasia (CHH) is a rare skeletal dysplasia characterized by disproportionate short stature, immunodeficiency, anemia and risk of malignancies. All these features can affect pregnancy and predispose to maternal and fetal complications. This study aimed to evaluate obstetric history and maternal and fetal outcomes in women with CHH. Methods Among 47 Finnish women with CHH, we identified 14 with pregnancy-related diagnoses in the National Hospital Discharge Registry and obtained detailed data on gynecologic and obstetric history with a questionnaire. Offspring birth length and weight were collected and compared with population-based normal values. Results There were altogether 42 pregnancies in 14 women (median height 124 cm, range 105–139). Twenty-six pregnancies (62%), including one twin pregnancy, led to a delivery. Miscarriages, induced abortions and ectopic pregnancies complicated 9, 5, and 2 pregnancies, respectively. Severe pregnancy-related complications were rare. All women with CHH delivered by cesarean section, mostly due to evident cephalo-pelvic disproportion, and in 25/26 cases at full-term. In the majority, the birth length (median 48 cm, range 45.5–50) and weight (3010 g, range 2100–3320) of the offspring in full-term singleton pregnancies was normal. Conclusions Despite CHH mothers’ significant short stature and other potential CHH-related effects on pregnancy outcome, most pregnancies lead to a term cesarean section delivery. Since fetal growth was generally unaffected, cephalo-pelvic disproportion was evident and elective cesarean section should be planned in term pregnancies.

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Section: Discussioncontrasting

confidence: 61%

Outcomes of 42 pregnancies in 14 women with cartilage-hair hypoplasia: a retrospective cohort study

Holopainen

Vakkilainen

Mäkitie

2020

Preprint

View full text Add to dashboard Cite

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“…In our cohort, 96% of babies were born fullterm, and there was only one early preterm birth (pw 25; 1/27 baby born, 3.7%). We did not observe any increase in the rate of complications, such as pregnancy-related hypertensive disorders or gestational diabetes, as compared with the general Finnish and Nordic population [26,27]. Maternal BMI was increased before pregnancy and an average weight gain during pregnancy was 8.4 kg (18.5 lb).…”

Section: Discussioncontrasting

confidence: 57%

Outcomes of 42 pregnancies in 14 women with cartilage-hair hypoplasia: a retrospective cohort study

Holopainen

Vakkilainen

Mäkitie

2020

Preprint

View full text Add to dashboard Cite

Background: Cartilage-hair hypoplasia (CHH) is a rare skeletal dysplasia characterized by disproportionate short stature, immunodeficiency, anemia and risk of malignancies. All theses features can affect pregnancy and predispose to maternal and fetal complications. This study aimed to evaluate obstetric history and maternal and fetal outcomes in women with CHH. Methods: Among 47 Finnish women with CHH, we identified 14 women with ICD codes related to pregnancies, childbirth and puerperium in the National Hospital Discharge Registry and obtained detailed data on gynecologic and obstetric history with a questionnaire. Offspring birth length and weight were collected and compared with population-based normal values. Results: There were altogether 42 pregnancies in 14 women (median height 124 cm, range 105-139 cm; 4'1'', range 3'5''-4'7''). Twenty-six pregnancies (62%), including one twin pregnancy, led to a delivery. Miscarriages, induced abortions and ectopic pregnancies complicated 9, 5 and 2 pregnancies, respectively. Severe pregnancy-related complications were rare. All women with CHH delivered by cesarean section, mostly due to evident cephalo-pelvic disproportion, and in 25/26 cases at full-term. In the majority, the birth length (median 48 cm, range 45.5-50 cm; 1'7'', range 1'6''-1'8'') and weight (3010 g, range 2100-3320 g; 6.6 lb, range 4.6-7.3 lb) of the offspring in full-term singelton pregnancies was normal. Conclusions: Despite CHH mothers' significant short stature and other potential CHH-related effects on pregnancy outcome, most pregnancies lead to a term cesarean section delivery. Since fetal growth was generally unaffected, cephalo-pelvic disproportion was evident and planned cesarean section should be planned in term pregnancies.

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“…All preeclamptic cases and 18 (95%) of the women developing gestational hypertension were classified as late onset (delivery after gestational week 34). Characteristics of the final study population are shown in Table 1 and are further described in Skråstad et al 35 In the study population, 98.5% of the women were classified as white. Compared with normotensive women at gestational weeks 11 0 -13 6 , women who later developed gestational hypertension had significantly higher body mass index, whereas women who later developed preeclampsia had higher uterine artery pulsatile index (UtAPI; Table 1).…”

Section: Characteristics Of the Study Populationmentioning

confidence: 99%

Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia

Tangerås

Austdal

Skråstad

et al. 2015

ATVB

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Objective-Gestational hypertension and preeclampsia involve dysregulated maternal inflammatory responses to pregnancy, but whether such responses differ between the disorders has not been determined. We aimed to investigate disease-specific early pregnancy serum cytokine profiles of women subsequently developing gestational hypertension or preeclampsia for new insight into the underlying pathogeneses and differences between the disorders. Approach and Results-The study cohort consisted of 548 pregnant Norwegian women who were either multiparous with previous gestational hypertension or preeclampsia or were nulliparous. Maternal sera at gestational weeks 11 0 -13 6 were assayed for 27 cytokines, C-reactive protein, total cholesterol, high-density lipoprotein, triglyceride, creatinine, calcium, uric acid, and placental growth factor. Compared with normotensive women, women with both hypertensive conditions presented an atherogenic lipid profile at early gestation, but only those later developing gestational hypertension had significantly higher serum levels of interleukin (IL)-5 and IL-12. Comparing the 2 hypertensive pregnancy disorders, women subsequently developing gestational hypertension had higher serum levels of IL-1β, IL-5, IL-7, IL-8, IL-13, basic fibroblast growth factor, and vascular endothelial growth factor than the women subsequently developing preeclampsia. Conclusions-This study identifies early pregnancy differences in serum cytokine profiles for gestational hypertension and preeclampsia.

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A prospective study of screening for hypertensive disorders of pregnancy at 11–13 weeks in a Scandinavian population

Cited by 21 publications

References 34 publications

Outcomes of 42 pregnancies in 14 women with cartilage-hair hypoplasia: a retrospective cohort study

Outcomes of 42 pregnancies in 14 women with cartilage-hair hypoplasia: a retrospective cohort study

Outcomes of 42 pregnancies in 14 women with cartilage-hair hypoplasia: a retrospective cohort study

Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia

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