A prospective study of prophylactic long-acting octreotide in high-risk patients undergoing pancreaticoduodenectomy

Systematic review and meta-analysis of outcomes after intraoperative pancreatic duct stent placement during pancreaticoduodenectomy

“…Despite substantial improvement in perioperative outcomes of PD, a significant proportion of patients undergoing PD develop PF, which is still the most frequent cause of postoperative death53, 54. A variety of strategies have been used to improve the safety of pancreatic–enteric anastomosis in recent years, based on technical or pharmacological approaches10–14. There are numerous theoretical reasons why a pancreatic stent should be useful in reducing PF formation, regardless of the type of stent used55.…”

“…A number of techniques have been proposed to reduce PF following PD. These include the use of the somatostatin analogue octreotide10, 11, reinforcement of the pancreaticoenteric anastomosis with fibrin glue12, placement of a pancreatic duct stent13, 14 and reconstruction with a pancreaticogastrostomy15. Results are often discordant, and definitive evidence regarding the ideal management and optimal surgical technique to reduce the postoperative PF rate is not yet available16.…”

Pancreatic Stump-Closed Pancreaticojejunostomy can be Performed Safely in Normal Soft Pancreas Cases

“…Octreotide was applied to all the cases prophylactically until the postoperative d 5. It is controversial whether routine use of octreotide should be recommended after pancreaticoduodenectomy [15][16][17]. As to treating a POPF, we think it is more important to drain effectively and prevent a secondary infection than octreotide injection.…”

Octreotide Prophylaxis Is Not Beneficial for Biochemical Activity and Clinical Severity of Postoperative Pancreatic Fistula after Pancreatic Surgery

“…While some European studies described a significant reduction of the incidence of POPF after pancreas resection using prophylactic octreotide treatment, several international studies failed to demonstrate this beneficial effect [11][12][13][14][17][18][19][20][21][22][23] . In a recently published meta-analysis, the overall incidence of POPF was lower in the group receiving prophylactic octreotide.…”