A prospective study of prevalence, risk factors, isolates &amp; antimicrobial sensitivity pattern in Asymptomatic Bacteriuria among Antenatal women in Rajarajeswari Medical College &amp; Hospital

Chunchaiah, Sarojamma; Nagothi, Nagendra Prasad; Bm, Roopakala; Rangaiah, Nagarathnamma

doi:10.5958/2394-2754.2016.00052.7

Cited by 3 publications

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“…10,11 Though the prevalence estimated is higher than few studies conducted in India which may be due to differences in composition of the population being catered to by this hospital. 12,13 In the current study, ABU was not found to have a statistically significant relation with age, haemoglobin level, parity, gestational period, education, residence or socioeconomic status even though different studies have found an association with some of these factors. This could be due to differences in population characteristics in terms of education and hygiene.…”

Section: Discussioncontrasting

confidence: 66%

“…This finding is similar to multiple other studies as most studies have found E. Coli to be the most common pathogen responsible for ABU. 12,16,17 The second most common pathogen responsible for ABU in our study was S. Aureus which has also been identified in multiple studies. 14,18 Among gram-negative organisms, it was followed by K. pneumonia, Pseudomonas and Proteus which contributed to 12.5%, 6.2% and 4% isolates respectively.…”

Section: Discussionsupporting

confidence: 55%

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Asymptomatic Bacteriuria in pregnant women attending a tertiary hospital in northern India: prevalence, risk factors, causative organisms and antimicrobial sensitivity pattern

2021

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Background: Asymptomatic bacteriuria is common and can lead to adverse foetal and maternal outcomes. Aims and Objective: The current study aimed to estimate the prevalence of asymptomatic bacteriuria (ABU), its associated risk factors, bacterial isolates and antimicrobial sensitivity pattern in pregnant women attending Outpatient department (services in a tertiary hospital in India. Materials and Methods: This was a hospital-based cross-sectional study among asymptomatic women coming for routine antenatal check-ups to obstetrics OPD of a teaching hospital in Northern India. Samples were collected, processed and antimicrobial sensitivity done as per Clinical and Laboratory Standards Institute (CLSI) guidelines. Data was analysed and p value below 0.05 was considered as statistically significant. Results: Overall 247 pregnant women were included in the study with a mean age of 25.9 ± 3.1. The overall prevalence of asymptomatic bacteriuria was 18.6%. The most common isolates responsible for ABU were E. Coli (48%), S Aureus (23%), K. pneumonia (12%), Pseudomonas (6%), Enterococcus (6%), Proteus (5%). Gram-negative isolates were mostly sensitive to Fosfomycin, Meropenem, Piperacillin + Tazobactum whereas gram-positive isolates were usually sensitive to Fosfomycin, Vancomycin and Linezolid Most isolates were resistant to Co-amoxiclav, Ciprofloxacin, and Nitrofurantoin. Conclusion: Considering the high prevalence of ABU and its association with adverse maternal and foetal outcomes, urine culture should be included in routine investigations being offered to pregnant women. Gram-negative bacteria were the primary causative agents with Fosfomycin, Meropenem and Ceftazidime showing high level of efficacy against the pathogens.

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Section: Discussioncontrasting

confidence: 66%

Section: Discussionsupporting

confidence: 55%

Asymptomatic Bacteriuria in pregnant women attending a tertiary hospital in northern India: prevalence, risk factors, causative organisms and antimicrobial sensitivity pattern

2021

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“…Several factors play a role in the development of ABU such as the number of pregnancies, physiological and anatomical changes, and poor genital hygiene. Being isolated from their samples to stop fetal and maternal morbidities, bacteria should be taken into consideration with its antimicrobial sensitivity patterns while treating the positive urine cultures of women (15). In pregnant women, progesterone relaxes uteretic smooth muscle, which causes dilatation of the uterus caused by the pressure from the enlarging uterus.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Asymptomatic Bacteriuria Agents and Antimicrobial Susceptibility in Term and Preterm Pregnancies

Aydın

GÜNEY²,

Emecen

et al. 2022

Düzce Tıp Fakültesi Dergisi

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Amaç: Bu çalışmanın amacı, asemptomatik bakteriüri (ASB) etkenlerinin direnç paternlerini term ve preterm gebelikler arasında karşılaştırmaktır. Gereç ve Yöntemler: Hastanemiz kadın doğum bölümünde takip edilen ve idrar kültürleri laboratuvarda incelenmek üzere gönderilen ve ASB olarak rapor edilen 17-41 yaş arası gebeler çalışmaya dahil edildi. Hastalar gebelik haftalarına göre preterm (<37 hafta) ve term (≥37 hafta) olmak üzere iki gruba ayrıldı. Sonuçlar iki grup arasında karşılaştırıldı. Bulgular: Toplam 123 gebeden 29'u (%23,6) preterm, 94'ü (%76,4) term doğum yaptı. Tüm çalışma grubunda en sık izole edilen patojen %52,0 (n=64) ile Escherichia coli (E. coli) idi ve bunu %16,3 (n=20) ile Streptococcus agalactiae (S.agalactiae) izlemekteydi. Term ve preterm grupları arasında E. coli ve S. agalactiae dağılımı açısından istatistiksel olarak anlamlı bir fark yoktu (p=0,698 ve p=0,930). E. coli suşları ampisiline %56,3 (n=36) oranında, sefuroksime %40,6 (n=26) oranında dirençliydi. Fosfomisin direnci %1,6 (n=1) olarak belirlenirken, nitrofurantoin direnci saptanmadı. E. coli suşlarında genişletilmiş spektrumlu beta-laktamaz pozitifliği %23,4 (n=15) olarak tespit edildi. Term ve preterm grupları arasında E. coli suşlarının antibiyotik direnç oranları bakımından istatistiksel olarak anlamlı fark saptanmadı. Sonuç: En sık izole edilen patojen bakteri, beta laktamlara oldukça dirençli olan E. coli idi. Gebelerin ASB için taranması ve uygun antibiyoterapi ile tedavisi; maternal ve fetüste gelişecek komplikasyonları ve antimikrobiyal direnci önlemede etkili bir yoldur.

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Prevalence of Asymptomatic Bacteriuria (ASB) in Pregnant Women in India: A Systematic Review and Meta-Analysis

Khapre,

Sharma,

Mehta

et al. 2023

Indian Journal of Community Medicine

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Background: Asymptomatic bacteriuria is prevalent during pregnancy. If it goes undetected, it can lead to urinary tract infection with severe maternal and neonatal complications. Until date, India does not have any guidelines to test for ASB during pregnancy. Objective: To estimate the pooled prevalence of asymptomatic bacteriuria in pregnant women at national level in India. Material and Methods: We searched Medline, Embase, Web of Science, and Google Scholar using search strategy with keyword. Two authors independently assessed the eligibility of study. The checklist of the JBI was used for evaluating the quality of reporting. The extracted data were analyzed, and the results were reported using a random-effects model with 95% confidence interval (CI). Subgroup analysis was conducted for zones of India, parity and trimester. Publication bias is reported as funnel plot. Result: Pooled prevalence of asymptomatic bacteriuria among pregnant women in India is 13.5% [CI 11.1; 15.8]. Subgroup analysis based on the various geographic zones of the country the pooled prevalence ranged from 9.2% in central zone to 14.8% in south zone. Distribution of prevalence of ASB as per parity was approximately identical. The prevalence of ASB was found to be high in third (21.8%). Conclusion: The prevalence of ASB is found to be high among Indian pregnant women, especially in third trimester. It is therefore recommended for guideline to screen and treat every pregnant woman for ASB to prevent further complications.

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A prospective study of prevalence, risk factors, isolates & antimicrobial sensitivity pattern in Asymptomatic Bacteriuria among Antenatal women in Rajarajeswari Medical College & Hospital

Cited by 3 publications

References 0 publications

Asymptomatic Bacteriuria in pregnant women attending a tertiary hospital in northern India: prevalence, risk factors, causative organisms and antimicrobial sensitivity pattern

Asymptomatic Bacteriuria in pregnant women attending a tertiary hospital in northern India: prevalence, risk factors, causative organisms and antimicrobial sensitivity pattern

Comparison of Asymptomatic Bacteriuria Agents and Antimicrobial Susceptibility in Term and Preterm Pregnancies

Prevalence of Asymptomatic Bacteriuria (ASB) in Pregnant Women in India: A Systematic Review and Meta-Analysis

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