A Prospective Study of Patterns of Urinary Tract Infections & Antibiotic Sensitivity In Rural setting of Mirpurkhas.

Abstract

Background: Urinary tract infection (UTI) is a common infection which can be caused by a variety of bacteria.The distribution of bacteria and effectiveness of antibiotics to those bacteria causing UTI can be different in different regions.Objective: To determine the frequency of the various organisms causing urinary tract infection, as well as findingtheir sensitivity to various antibiotics in patients attending Urological OPD of Muhammad Medical College.Material and Methods: Between 1" Oct 2008 to 31" Jan 2009, urine samples were collected from 457 patientsattending urology outpatient with clinical diagnosis of UTI prospectively. 152 met the exclusion criteria. Remaining 305 samples were cultured. 111 were sterile and 194 had positive culture. Of these 194 patients with confirmed UTI, 131 were male and 63 females. The sensitivity was tested for 15 commonly used drugs.Results: The commonest causative organism was Escherichia coli (E. Col), which was present in 78 (40H%)samples. This is half the number of E. Coli induced infection found in studies conducted in other parts of theworld. 45 (23) grew Klebsiella and 33 (17%) grew Staphylococcus. More than 70% of samples were sensitive toAmikacin (149, 77%), Fosfomycin (144, 74%) and Imipenem (144, 74%6).Conclusion: The distribution of bacteria causing urinary tract infection and their sensitivity to various antibioticsare different from those reported in most standard textbooks and guidelines.Keywords: Infection, urinary tract, sensitivity, antibiotics.