A prospective study of nomogram-based adaptation of prostate radiotherapy target volumes

Abstract

BackgroundA prospective clinical trial was conducted to evaluate the feasibility of a novel approach to the treatment of patients with high risk prostate cancer (HRPC) through the use of a nomogram to tailor radiotherapy target volumes.MethodsTwenty seven subjects with HRPC were treated with a mildly hypofractionated radiotherapy regimen using image-guided IMRT technique between Jun/2013-Jan/2015.A set of validated prognostic factors were inputted into the Memorial-Sloan-Kettering Cancer Center (MSKCC) prostate cancer nomogram to estimate risk of loco-regional spread (LRS). The nomogram risk estimates for extra-capsular extension (ECE), seminal vesicles involvement (SVI), and pelvic lymph nodes involvement (LNI) were used to adapt radiotherapy treatment volumes based on a risk threshold of ≥15 % in all cases. A planning guide was used to delineate target volumes and organs at risk (OAR). Up to three dose levels were administered over 28 fractions; 70Gy for gross disease in the prostate +/− seminal vesicles (2.5Gy/fraction), 61.6Gy for subclinical peri-prostatic disease (2.2Gy/fraction) and 50.4Gy to pelvic nodes (1.8Gy/fraction).Data regarding protocol adherence, nomogram use, radiotherapy dose distribution, and acute toxicity were collected.ResultsNomogram use100 % of patients were treated for ECE, 88.9 % for SVI, and 70.4 % for LNI. The three areas at risk of LRS were appropriately treated according to the study protocol in 98.8 % cases. The MSKCC nomogram estimates for LRS differed significantly between the time of recruitment and analysis.Contouring protocol complianceCompliance with the trial contouring protocol for up to seven target volumes was 93.0 % (159/171). Compliance with protocol for small bowel contouring was poor (59.3 %).Dose constraints complianceCompliance with dose constraints for target volumes was 97.4 % (191/196). Compliance with dose constraints for OAR was 88.2 % (285/323).Acute toxicityThere were no grade 3 acute toxicities observed. 20/27 (74.1 %) and 6/27 (22.2 %) patients experienced a grade 2 genitourinary and gastrointestinal toxicity respectively.ConclusionsWe have demonstrated the feasibility of this novel risk-adapted radiation treatment protocol for HRPC. This study has identified key learning points regarding this approach, including the importance of standardization and updating of risk quantification tools, and the utility of an observer to verify their correct use.Trial registrationClincialTrials.gov identifier NCT01418040.Hunter New England Human Research Ethics Committee (HNEHREC) reference number 12/08/15/4.02

Detection level and pattern of positive lesions using PSMA PET/CT for staging prior to radiation therapy

“…Like the analysis by Henkenberens et al on 29 patients with biochemical recurrence receiving an individualized radiotherapy treatment plan based on PSMA PET/CT findings [ 38 ], target volumes are modified accordingly in our institution after critical assessment. Nevertheless, keeping the sensitivity and specificity rates from surgical series in mind, PSMA PET/CT might still underestimate the true extent of disease and should therefore from our point of view not result in an omission of nomogram [ 39 ] triggered radiotherapy treatment volumes.…”

Assessment and predictors of fatigue in men with prostate cancer receiving radiotherapy and androgen deprivation therapy

“…They received a dose of 70 Gy to the prostate, at 2.5 Gy per fraction, with 61.6 Gy to periprostatic regions and 50.4 Gy to the pelvic lymph nodes depending on nomogram predicted risk of involvement as previously reported. Pre‐treatment kilovoltage imaging was performed with intraprostatic gold seed fiducial marker matching for accurate image guidance. Following RT, men continued on ADT for a total of 18 months.…”

Spinal multiparametric MRI and DEXA changes over time in men with prostate cancer treated with androgen deprivation therapy: a potential imaging biomarker of treatment toxicity

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