A prospective study of maternal fatty acids, micronutrients and homocysteine and their association with birth outcome

Wadhwani, Nisha; Pisal, Hemlata; Mehendale, Savita; Joshi, Sadhana

doi:10.1111/mcn.12062

Cited by 30 publications

(27 citation statements)

References 94 publications

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“…The fatty acid composition, relative to total fatty acids, was also largely modified during pregnancy. Similar findings for maternal fatty acids and their proportions in plasma and plasma phospholipids have been reported previously [39, 40]. DHA may be of particular importance to fetal brain and retinal development [38].…”

Section: Discussionsupporting

confidence: 84%

Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence

Wang

Würtz

Auro

et al. 2016

BMC Med

160

172

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BackgroundPregnancy triggers well-known alterations in maternal glucose and lipid balance but its overall effects on systemic metabolism remain incompletely understood.MethodsDetailed molecular profiles (87 metabolic measures and 37 cytokines) were measured for up to 4260 women (24–49 years, 322 pregnant) from three population-based cohorts in Finland. Circulating molecular concentrations in pregnant women were compared to those in non-pregnant women. Metabolic profiles were also reassessed for 583 women 6 years later to uncover the longitudinal metabolic changes in response to change in the pregnancy status.ResultsCompared to non-pregnant women, all lipoprotein subclasses and lipids were markedly increased in pregnant women. The most pronounced differences were observed for the intermediate-density, low-density and high-density lipoprotein triglyceride concentrations. Large differences were also seen for many fatty acids and amino acids. Pregnant women also had higher concentrations of low-grade inflammatory marker glycoprotein acetyls, higher concentrations of interleukin-18 and lower concentrations of interleukin-12p70. The changes in metabolic concentrations for women who were not pregnant at baseline but pregnant 6 years later (or vice versa) matched (or were mirror-images of) the cross-sectional association pattern. Cross-sectional results were consistent across the three cohorts and similar longitudinal changes were seen for 653 women in 4-year and 497 women in 10-year follow-up. For multiple metabolic measures, the changes increased in magnitude across the three trimesters.ConclusionsPregnancy initiates substantial metabolic and inflammatory changes in the mothers. Comprehensive characterisation of normal pregnancy is important for gaining understanding of the key nutrients for fetal growth and development. These findings also provide a valuable molecular reference in relation to studies of adverse pregnancy outcomes.Electronic supplementary materialThe online version of this article (doi:10.1186/s12916-016-0733-0) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 84%

Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence

Wang

Würtz

Auro

et al. 2016

BMC Med

160

172

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“…In relation to folate, some studies suggest a negative association between high maternal folate status and risk of low birth weight or small-for-gestational-age babies (van Uitert and SteegersTheunissen 2013). Meanwhile,vitamin B 12 deficiency has been associated with reduced birth weight (Wadhwani et al 2013), but no association with small-for-gestational-age babies has been found (Abraham et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Maternal dietary intake of folate, vitamin B12 and MTHFR 677C>T genotype: their impact on newborn’s anthropometric parameters

et al. 2014

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In this study, we evaluated the effects of dietary intake of vitamin B 12 and folate during pregnancy and their interactions with maternal polymorphism of MTHFR (677C[T; 1298A[C) on intrauterine development. Anthropometric parameters were obtained from 231 newborns that belong to a prospective birth cohort in Morelos, Mexico. Maternal dietary intake of vitamin B 12 and folate was assessed using a semi-quantitative questionnaire administered during the first and third trimesters of the pregnancy. Maternal MTHFR 677C[T and 1298 A[C genotypes were determined by PCR-RFLP. The associations between deficient dietary intake of vitamin B 12 (\2.0 lg/d) and folate (\400 lg/d) in the first and third trimesters and maternal polymorphisms of MTHFR on anthropometric parameters at birth were estimated using a multivariate linear regression model. During pregnancy, the deficient dietary intake was roughly 60 % for folate and 19 % for vitamin B 12 . Allelic frequencies of 677T and 1298C were 59 and 10 %, respectively. After adjusting for confounders, deficiency in maternal dietary intake of vitamin B 12 (\2.0 lg/d) was associated with a significant reduction in length (b * -2.4; 95 % CI -4.3; -0.6) and length-for-age at birth (b * -1.2; 95 % CI -2.3; -0.1) among infants whose mothers were carriers of the 677TT genotype (p for interaction = 0.02). In contrast, no association was observed between deficiency in maternal dietary intake of folate (\400 lg/d) and any anthropometric parameter of newborns. These results suggest that supplementation with vitamin B 12 during pregnancy could have a favorable impact on intrauterine fetal development mainly in populations that are genetically susceptible.

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“…DHA supplementation reduces significantly the effects of prenatal stress and the perinatal mortality rate and also, increases the birth weight [46,48]. However for recurrent IUGR, it is not clear that a routine supplementation could improve fetal growth [50].…”

Section: Discussionmentioning

confidence: 99%

“…In a prospective study, Wadhwani et al reported a positive correlation between the maternal and umbilical cord plasma DHA concentrations and birth weight [48].…”

Section: Dha and Fetal Growthmentioning

confidence: 99%

Maternal and fetal benefits of DHA supplementation during pregnancy

Hubinont¹,

Savoye²

2017

J Pregnancy Reprod

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During pregnancy, the benefits of long-chain n-3 fatty acids, mainly DHA supplementation has been reported with controversial results. The aim of this review paper is to clarify the role of DHA on maternal and fetal outcomes and to discuss supplementation.Low maternal concentrations of DHA are associated with an increased incidence of preeclampsia, gestational diabetes, postpartum depression, preterm labour and intrauterine fetal growth restriction (IUGR).The effect of a preventive supplementation on these complications is not clearly demonstrated . Some authors report an improved outcome but recent Cochrane database systematic reviews and meta-analysis are not conclusive.DHA supplementation reduces significantly the effects of prenatal stress and the perinatal mortality rate. In patients with previous history of preterm birth, supplementation is also controversial.In conclusion, even if the DHA requirements are increased in pregnancy and if positive correlations are reported between low maternal concentrations and an adverse pregnancy outcome, there are conflicting results on the efficacy of a DHA supplementation. Further studies using different DHA regimens of administration are needed. In the meantime, as it is a safe supplementation with few side effects, DHA should be prescribed in patients with a low dietary intake and risks factors.

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A prospective study of maternal fatty acids, micronutrients and homocysteine and their association with birth outcome

Cited by 30 publications

References 94 publications

Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence

Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence

Maternal dietary intake of folate, vitamin B12 and MTHFR 677C>T genotype: their impact on newborn’s anthropometric parameters

Maternal and fetal benefits of DHA supplementation during pregnancy

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