A Prospective Study of Incident Nonmelanoma Skin Cancer in Heart Transplant Recipients

España, A.; Martínez-González, M Á; Garcı́a-Granero, Marta; Sánchez‐Carpintero, I.; Rábago, Gregorio; Herreros, J.

doi:10.1046/j.1523-1747.2000.0202a-3.x

Cited by 50 publications

(58 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All recipients had at least 6 months of follow-up after transplant. Children younger than 18 years at the time of transplant were excluded. Recipients were followed up until death or the end of the enrollment period (November 2000).…”

Section: Methodsmentioning

confidence: 99%

Risk factors associated with the development of skin cancer after liver transplantation

Mithoefer

Supran

Freeman

2002

Liver Transplantation

View full text Add to dashboard Cite

Skin cancer is a well-recognized long-term complication of transplantation and immunosuppression. Although risk factors for the development of skin cancer in the general population are well defined, risk factors for the development of these lesions have not been identified clearly in the liver transplant population. We surveyed 151 liver transplant (LTx) recipients for risk factors associated with cutaneous malignancies in the general population. Variables included were: demographics, primary liver disease, severity of disease at LTx, immunosuppression history, complexion, hair color, eye color, tanning profile, number of moles, occupational history, sun exposure history, sunburn history, family history of skin cancer, and any history of removed skin lesions. All skin cancers were confirmed histologically. There were 86 documented skin cancers in 34 patients: 56 squamous cell, 23 basal cell and 7 melanomas. Median follow-up was 1490 days. In a univariate analysis, age, male gender, red hair, brown eyes, primary sclerosing cholangitis (PSC), primary biliary cirrhosis (protective), cyclosporine, number of second degree sunburns, and frequent lifetime sun exposure were associated with the development of new skin cancers. In a multivariate model, age, male gender, red hair, brown eyes, PSC, and cyclosporine remain the strongest predictors. The incidence of skin cancer after liver transplantation is underestimated. In particular, there is a higher incidence of squamous cell carcinoma compared with the general population. Recipients with identified risk factors may be candidates for prophylactic treatment and should be followed more intensively after liver transplantation. (Liver TranspZ2002;8:939-944.) T he incide,nce of skin cancer in the general population continues to rise, with more than 1.3 million cases of nonmelanoma skin cancer expected to occur in the United States alone this year.l Risk factors for skin cancer in the general population are well known and include exposure to ultraviolet radiation, sun exposure during childhood, a history of second degree sunburns, the tendency to sunburn easily, fair complexion, blonde or red hair, blue or hazel eyes, occupational exposure, and outdoor Skin cancer is the most common malignancy occurring after solid organ transplantation, with the incidence as high as 35% to 70% at 20 years in parts of the world in which sun exposure is more common.3 The incidence after liver transplantation (LTx) specifically has been reported at 1.6% to 2.2?40415 in two studies with a mean follow-up ranging between 35 and 77.8 months, but there are few published reports, and the length of follow-up in these studies is limited compared with the extensive longterm data in renal transplant patients. In addition, these studies often rely on retrospectively collected singlecenter data or composite registry data, information that patients may not provide spontaneously without specific direct questioning. Although skin cancer is a wellrecognized long-term complication of transplantation and immuno...

show abstract

Section: Methodsmentioning

confidence: 99%

Risk factors associated with the development of skin cancer after liver transplantation

Mithoefer

Supran

Freeman

2002

Liver Transplantation

View full text Add to dashboard Cite

show abstract

“…Ultraviolet radiation appears to be the most important responsible factor, 6 as skin cancers are likely to develop on sun-exposed areas and in transplant recipients with high sun exposure after transplant (> 10 000 hours). 28,29 The incidence of skin cancer is proportional to the level of immunosuppression, with rejection episodes in the first year resulting in higher incidence. 8 They are more frequent in individuals with fair skin (Fitzpatrick scale type II), blue eyes, or blonde or red hair.…”

Section: Malignancies After Heart Transplantmentioning

confidence: 99%

“…8 They are more frequent in individuals with fair skin (Fitzpatrick scale type II), blue eyes, or blonde or red hair. 27,28,30 The probability of developing skin cancer in heart transplant patients increases with time, 16 with no sex predominance. 31 Carcinomas are the most common cancers seen in heart transplant patients, with squamous cell carcinoma being the most common form.…”

Section: Malignancies After Heart Transplantmentioning

confidence: 99%

Untitled

Lateef

Basit²,

Abbasi³

et al. 2016

Exp Clin Transplant

View full text Add to dashboard Cite

Along with graft vasculopathy, malignancies comprise a major complication after heart transplant, with a rate of occurrence of 39.1% in 10 years. Skin cancers and posttransplant lymphoproliferative disorder are more common in adults, whereas lymphoma is more often shown in children. A major cause of malignancies after heart transplant is the use of increased doses of prophylactics needed during immunosuppressive therapy. Data, however, are scarce regarding the association between a particular immunosuppressive drug and a posttransplant malignancy. Compared with the general population, recipients have a higher incidence of malignancies after heart transplant, with an early onset and more aggressive disease. Solid tumors known to occur in heart transplant recipients include lung cancer, bladder and prostate carcinoma, adenocarcinoma of the oral cavity, stomach cancer, and bowel cancer, although the incidence is rare. The risk factors for development of a malignancy after heart transplant are the same as for the nontransplant population.

show abstract

“…(35) Similarly, in heart transplant recipients, the cumulative risk rose from 4.3% at 1 year up to 43.8% at 7 years after transplantation. (37,38) More importantly, the incidence and risk of malignancy particularly cSCC is significantly elevated in post-transplant patients compared to other patient populations.…”

Section: Immunologic Altered Host Statementioning

confidence: 99%