A prospective study of impaired fasting glucose and type 2 diabetes in China

Vaidya, Anand; Sun, Lixia; Chen, Shuohua; Liu, Xing; Zhou, Yong; Xiu-rong, Liu; Xie, Xiaobing; Hu, Frank B.; Wu, Shouling; Gao, Xiang

doi:10.1097/md.0000000000005350

Cited by 25 publications

(22 citation statements)

References 18 publications

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“…In fact, differently from impaired glucose tolerance (IGT), requiring the oral glucose tolerance test (OGTT) to be diagnosed, IFG may be easily identified with a simple FPG measurement. [ 48 , 49 ] However, to date, no study confirmed the predictive role of IFG in RA patients. Furthermore, we observed that a higher BMI, the presence of MetS, as well as a higher serum level of total cholesterol were significantly associated with IFG, confirming the well-known role of traditional CV risk factors in this context.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of type 2 diabetes and impaired fasting glucose in patients affected by rheumatoid arthritis

et al. 2017

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Although the better management of rheumatoid arthritis (RA) has significantly improved the long-term outcome of affected patients, a significant proportion of these may develop associated comorbidities including cardiometabolic complications. However, it must be pointed out that a comprehensive cardiometabolic evaluation is still poorly integrated into the management of RA patients, due to a limited awareness of the problem, a lack of appropriate clinical studies, and optimal strategies for cardiovascular (CV) risk reduction in RA. In addition, although several studies investigated the possible association between traditional CV risk factors and RA, conflicting results are still available.On this basis, we planned this cross-sectional study, aimed at investigating the prevalence of type 2 diabetes (T2D) and impaired fasting glucose (IFG) in RA patients compared with age- and gender- matched control individuals. Furthermore, we analyzed the role of both traditional and RA-related CV risk factors in predicting T2D and IFG.We observed an increased prevalence of T2D in RA patients when compared with age- and gender-matched controls. Regression analyses demonstrated that the presence of high blood pressure (HBP), a longer disease duration, and exposure to corticosteroids (CCS) were significantly associated with an increased likelihood of being classified as T2D. In addition, we observed an increased prevalence of IFG in RA patients when compared with age- and gender-matched controls. Regression analyses demonstrated that a higher body mass index (BMI), the presence of metabolic syndrome (MetS), higher levels of total cholesterol, the presence of radiographic damage, and higher serum levels of C-reactive protein (CRP) were significantly associated with an increased likelihood of presenting IFG.In this cross-sectional study, we observed an increased prevalence of T2D and IFG in an Italian cohort of RA patients when compared with age- and gender-matched control individuals. Interestingly, both RA-specific features, such as disease duration, CCS exposure, and radiographic damage, and traditional CV risk factors, such as HBP and MetS, were significantly associated with glucose metabolism abnormalities.

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Section: Discussionmentioning

confidence: 99%

Prevalence of type 2 diabetes and impaired fasting glucose in patients affected by rheumatoid arthritis

et al. 2017

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“…The cut-off value for the definition of impaired fasting glycaemia (IFG) is still controversial at present; the American Diabetes Association (ADA) Expert Committee reduced the cut-off value of IFG to 5.6 mmol/L in 2003, while the World Health Organization (WHO) retained the previous cut-off value of IFG (6.1 mmol/L) 19 . Further, IFG has been shown as an independent risk factor for hypertension 20 , 21 ; however, whether the FBG level begin to become a potential risk factor for hypertension when it is close to 5.6 mmol/L is uncertain. Fortunately, our study showed that the positive associations of BP with FBG became stronger when FBG levels were close to 5.6 mmol/L, which implied that FBG level might begin to become a potential risk factor for hypertension when it was close to 5.6 mmol/L.…”

Section: Discussionmentioning

confidence: 99%

Association of Blood Pressure with Fasting Blood Glucose Levels in Northeast China: A Cross-Sectional Study

Yao

et al. 2018

Sci Rep

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Hypertension and diabetes mellitus (DM) have become major public health issues, and previous studies have shown that there is an association between hypertension and DM. However, there is a lack of detailed information about this association. This study aimed to explore how different blood pressure (BP) levels were associated with fasting blood glucose (FBG) levels. A cross-sectional survey with adults aged 18 to 79 years was conducted in Jilin Province, China in 2012. Lambda-mu-sigma (LMS) was used to preliminarily explore the associations of BP with FBG. Quantile regression (QR) was performed to identify the specific associations by adjusting for confounding factors. The distributions of systolic blood pressure (SBP) (χ2 = 710.76, P < 0.001) and diastolic blood pressure (DBP) (χ2 = 460.20, P < 0.001) were different according to gender. LMS showed that the associations of BP with FBG became stronger when the FBG levels were close to 5.6 mmol/L. QR showed that FBG was positively associated with SBP (P30 to P90) and DBP (P20 to P90) in males. In females, FBG was positively associated with SBP from only P85 to P90. In summary, FBG was positively associated with BP in a gender-dependent manner.

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“…While in women, the estimates were 3.8, 11.5, and 11.9 cases per 1000 population in the same age categories, respectively. [ 15 ] Vaidya et al [ 16 ] showed that incident diabetes rates in the Kailuan cohort were 10.4, 17.5, and 17.9 cases per 1000 population in men aged 18 to 44, 45 to 64, and 65+ years, and 3.6, 13.1, and 19.5 cases per 1000 population in women of the same age groups. These findings indicated that both males and females showed higher percentage of diabetes with ages increasing, and males showed higher percentage of diabetes compared with females in the same age groups.…”

Section: Discussionmentioning

confidence: 99%

Follow-up of blood glucose distribution characteristics in a health examination population in Chengdu from 2010 to 2016

Wang

Zhang³

et al. 2018

Medicine

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A prospective study of impaired fasting glucose and type 2 diabetes in China

Abstract: Supplemental Digital Content is available in the text

Cited by 25 publications

References 18 publications

Prevalence of type 2 diabetes and impaired fasting glucose in patients affected by rheumatoid arthritis

Prevalence of type 2 diabetes and impaired fasting glucose in patients affected by rheumatoid arthritis

Association of Blood Pressure with Fasting Blood Glucose Levels in Northeast China: A Cross-Sectional Study

Follow-up of blood glucose distribution characteristics in a health examination population in Chengdu from 2010 to 2016

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