A Prospective Study of Hyperprolactinemia in Children and Adolescents Treated with Atypical Antipsychotic Agents

Saito, Ema; Correll, Christoph U.; Gallelli, Kim; McMeniman, Marjorie; Parikh, Umesh H.; Malhotra, Anil K.; Kafantaris, Vivian

doi:10.1089/cap.2004.14.350

Cited by 57 publications

(11 citation statements)

References 18 publications

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“… 12 None of the children in our study reported adverse effects related to hyperprolactinemia, although one study found that 25% of subjects experienced sexual side effects. 13 However, Johnsen and colleagues found no correlation (Pearson) between prolactin levels and symptoms, and some of their patients did not report any symptoms despite the presence of hyperprolactinemia. 14 …”

Section: Discussionmentioning

confidence: 94%

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The Short-Term Effects of Risperidone-Induced Hyperprolactinemia on Lipid Metabolism in Drug-Naïve Children and Adolescents

Park

2015

Psychiatry Investig

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ObjectiveThe present cross-sectional study was designed to assess the risk of elevated prolactin levels and other hormonal or metabolic changes in children and adolescents taking risperidone.MethodsTwenty-five children and adolescents [aged 7-18 years, 12.1±3.3 years (mean±SD); 19 boys and 6 girls] who had been taking risperidone for at least 3 months were enrolled. The following blood parameters were measured: serum levels of prolactin, thyroid hormones, alanine transaminase (ALT), sex hormones, lipids.ResultsThe median risperidone dosage was 1.55 mg/day (SD 1.14 mg/day, range 0.25-4.00 mg/day). The prolactin level (33.65±16.71 ng/mL, range 5.8-68.3 ng/mL) was higher than normal, and was elevated (≥15 ng/mL in male, ≥23.3 ng/mL in female) in about 84% of the patients. The dosage of risperidone was positively correlated with serum prolactin level (r=0.767, p<0.001). The TG/HDL ratio was higher in the group with higher prolactin levels (i.e., ≥30 ng/mL), and hence might be a useful marker of insulin resistance.ConclusionIn young patients taking risperidone, a high serum prolactin level may influence lipid metabolism, even when cholesterol levels are within the normal range. Further investigation is needed around this issue. Serum prolactin assessment is recommended for children and adolescents taking risperidone.

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Section: Discussionmentioning

confidence: 94%

“… 18 Female hormones such as estrogen increase prolactin synthesis and intensify prolactin response to atypical or typical antipsychotics. 13 , 19 …”

Section: Discussionmentioning

confidence: 99%

The Short-Term Effects of Risperidone-Induced Hyperprolactinemia on Lipid Metabolism in Drug-Naïve Children and Adolescents

Park

2015

Psychiatry Investig

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“…Gynaecomastia, galactorrhoea, oligomenorrhoea and amenorrhoea are all known to be associated with hyperprolactinaemia; 36 however, none of the studies in this review reported these clinical changes. These adverse events are particularly noticeable in adolescents 37 and potentially have adverse effects on developmental tasks.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of risperidone in children with disruptive behavioural disorders

Duhig

Saha

Scott

2011

J Paediatrics Child Health

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This study aims to review the evidence for the efficacy of risperidone in the treatment of disruptive behavioural disorders (DBDs) in children and adolescents. Established databases were searched using the terms 'Risperidone and efficacy and children' and 'Risperidone and efficacy and adolescents'. Randomised, double-blind controlled studies were retained for analysis. Janseen-Cilag was contacted to identify any unpublished studies. Quality of studies was measured using Jadad scores. Seven studies of 657 subjects with a mean age of 9.9 years (SD= 2.0) (range 4-18 years) were identified. Only one study was judged to use the highest quality of methodology according to the Jadad score. Patients with DBD who were treated with risperidone showed clinical improvement compared with placebo. Weight gain, somnolence and gastrointestinal complaints were common. Risperidone was found to be efficacious in reducing symptoms in children and adolescents with DBD. However, studies were mostly of short duration and had deficiencies in the descriptions of blinding and randomisation. Research using rigorous methodology examining the long-term outcomes of efficacy and safety are required to inform clinicians and families of the therapeutic benefits and risks of risperidone in this clinical population.

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“…[23][24][25] Significant elevations above 60 ng/mL are not uncommon. [23][24][25] Significant elevations above 60 ng/mL are not uncommon.…”

Section: Adverse Effects and Tolerabilitymentioning

confidence: 99%

Update on the Use of Risperidone for the Treatment Of Youth With Schizophrenia and ipolar Disorder

Bishop

Pavuluri

2008

Psychopharm Review

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A Prospective Study of Hyperprolactinemia in Children and Adolescents Treated with Atypical Antipsychotic Agents

Abstract: Risperidone significantly increased prolactin levels in children and adolescents. The duration of this prolactin elevation, and its long-term effects in children and adolescents, are unknown.

Cited by 57 publications

References 18 publications

The Short-Term Effects of Risperidone-Induced Hyperprolactinemia on Lipid Metabolism in Drug-Naïve Children and Adolescents

The Short-Term Effects of Risperidone-Induced Hyperprolactinemia on Lipid Metabolism in Drug-Naïve Children and Adolescents

Efficacy of risperidone in children with disruptive behavioural disorders

Update on the Use of Risperidone for the Treatment Of Youth With Schizophrenia and ipolar Disorder

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