A prospective study of freezing of gait with early Parkinson disease in Chinese patients

Zhang, Hongbo; Yin, Xifan; Ouyang, Zhiyuan; Chen, Jing; Zhou, Sijie; Zhang, Changguo; Pan, Xin; Wang, Shiliang; Yang, Jing‐Fang; Yu, Feng; Yu, Peng; Zhang, Qiangchun

doi:10.1097/md.0000000000004056

Cited by 54 publications

(90 citation statements)

References 31 publications

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“…Our previous cross‐sectional study (Ou et al., ) has found that patients with onset in lower limbs were associated with the presence of FOG. In the current study, we verified that patients with onset in lower limbs were likely to develop FOG episodes, which is in accordance with the finding of another prospective study from China (Zhang et al., ). The pathophysiological mechanism of FOG episodes is poorly understood.…”

Section: Discussionsupporting

confidence: 93%

“…In the current study, we found that patients with longer disease duration are more likely to develop FOG episodes. This is consistent with the findings of a previous prospective study (Giladi et al., ) and several cross‐sectional studies (Garcia‐Ruiz, del Val, Fernandez, & Herranz, ; Giladi et al., ; Macht et al., ), but is not consistent with the results from two other prospective studies (Forsaa et al., ; Zhang et al., ). Our study also found that higher disease severity is a risk factor for FOG.…”

Section: Discussionsupporting

confidence: 85%

“…In another 12‐year follow‐up study, the authors found that severe disease dysfunction was not associated with developing FOG, while motor fluctuations and higher levodopa dose at baseline are independent risk factors for the development of FOG in PD (Forsaa, Larsen, Wentzel‐Larsen, & Alves, ). A recent three‐year follow‐up study did not find an association between levodopa treatment and future FOG episodes, but suggested that the absence of dopamine agonist receptor use is a risk factor for FOG (Zhang et al., ). In addition, they also found that lower educated patients and those who had a symptom of anxiety or onset of PD in lower limbs are more likely to develop FOG (Zhang et al., ).…”

Section: Introductionmentioning

confidence: 99%

“…A recent three‐year follow‐up study did not find an association between levodopa treatment and future FOG episodes, but suggested that the absence of dopamine agonist receptor use is a risk factor for FOG (Zhang et al., ). In addition, they also found that lower educated patients and those who had a symptom of anxiety or onset of PD in lower limbs are more likely to develop FOG (Zhang et al., ). Based on the differences in follow‐up period, sample size, genetic background, and assessment tool, above longitudinal researches exhibit inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

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Predictors of freezing of gait in Chinese patients with Parkinson's disease

Wei

Cao

et al. 2018

Brain and Behavior

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Objective: To explore the clinical predictors of freezing of gait (FOG) in Chinese patients with Parkinson's disease (PD). Methods:This study included 225 patients with PD who completed a three-year follow-up visit. The end-point was the presence of FOG (freezers), which was assessed during the follow-up visit. Group comparisons were conducted, followed by a further forward binary logistic regression analysis.Results: Eighty-five patients with PD (38%) had developed FOG at the end of study.At baseline, freezers exhibited higher age, longer disease duration, higher scores in Unified PD Rating Scale (UPDRS) III and Hamilton Depression/Anxiety Rating Scale, lower Frontal Assessment Battery (FAB) score, higher subscores (e.g., "urgency") and frequencies (e.g., "hallucinations") in Non-Motor Symptoms Scale, higher annual changes in MoCA, UPDRS III and FAB scores, and higher incidences of festination and falls than nonfreezers (p < .05). The forward binary logistic regression model indicated that a longer disease duration, a higher UPDRS III score, higher annual changes in UPDRS III score and "visuospatial/executive abilities" subscore, onset in lower limbs, and the presence of festination, falls, and hallucinations were associated with the development of FOG. Conclusions:Patients with onset in the lower limbs and the presence of festination, falls, and hallucinations may be prone to develop FOG episodes. FOG also likely occurs with the deterioration of PD severity and visuospatial function.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Predictors of freezing of gait in Chinese patients with Parkinson's disease

Wei

Cao

et al. 2018

Brain and Behavior

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“…It has been shown that education level has a significant impact on the clinical presentation of symptoms in PD [63]. Health beliefs have also been related to cultural differences, and therefore might influence the perception of PD and individual symptoms.…”

Section: Discussionmentioning

confidence: 99%

Non-Motor Symptoms Assessed by Non-Motor Symptoms Questionnaire and Non-Motor Symptoms Scale in Parkinson's Disease in Selected Asian Populations

Sauerbier

Jitkritsadakul²,

Titova³

et al. 2017

Neuroepidemiology

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Background: Ethnic variations have been described in medical conditions, such as hypertension, diabetes, and multiple sclerosis. Whether ethnicity plays a role in Parkinson's disease (PD), particularly with regard to non-motor symptoms (NMS), remains unclear. Existing literature is diverse, controversial, and inadequately documented. This review aims to analyse and report the currently available literature on NMS, specifically in Asian PD patients. Summary: We conducted a literature review using PubMed, searching for articles and currently available publications that reference and assess NMS in PD patients living in Asia using the validated NMS Questionnaire (NMS Quest) and NMS Scale (NMSS). In total, 24 articles were included: 12 using the NMS Quest and 12 using the NMSS. Symptoms of constipation, memory impairment, and nocturia were the most frequently self-reported symptoms (NMS Quest) in selected Asian populations, while symptoms within the domains sleep/fatigue, attention/memory, and mood/apathy were most prevalent when applying the health-professional completed NMSS. Key Messages: NMS are generally prevalent and highly burdensome within selected Asian PD populations living in countries included in this review. Our review suggests that NMS-driven phenotypic heterogeneity is present in Asian patients, and compared to Western PD populations there might be variations in assessed NMS.

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Clinical features and related factors of freezing of gait in patients with Parkinson's disease

et al. 2021

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Background: Freezing of gait (FOG) is a disabling paroxysmal gait disorder that prevents starting or resuming walking, which seriously negatively affects patients' quality of life (QOL). The diagnosis and treatment of FOG remain a huge medical challenge.The purpose of this study was to explore the clinical characteristics and related factors of FOG in patients with Parkinson's disease (PD). Methods:The motor and nonmotor symptoms of a total number of 77 PD patients were evaluated. Patients with or without FOG were defined as a score ≥1 in the new freezing of gait questionnaire (NFOG-Q). A comparative study between patients with and without FOG was conducted. Results:In this investigation, the prevalence of FOG was 48%. The patients with FOG had longer disease duration, higher Hoehn-Yahr stage (H-Y stage), higher dose of dopaminergic agents, and higher nonmotor and motor symptom scores. A significant positive correlation was found between the NFOG-Q score and the H-Y stage, PIGD subscore, PDQ-39, and the attention/memory in the nonmotor symptoms assessment scale (NMSS) subitem (r > 0.5, p < .05). The binary logistic regression analysis showed that the higher H-Y stage, higher rigidity subscore and Unified Parkinson's Disease Rating Scale II (UPDRS II) score, and UPDRS III score were significantly correlated with the occurrence of FOG (p < .05). In the analysis of the frequency of FOG, the prevalence of FOG in H-Y stage was higher in the middle and late stages, and the prevalence of FOG increased with the increase in PDQ-39 scores. Conclusion:The severity of FOG was significantly positively correlated with the H-Y stage, PIGD subscore, PDQ-39 score, and attention/memory score. Based on our findings, we conclude that the clinical characteristics of rigidity can be used as a potential predictor of FOG.

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A prospective study of freezing of gait with early Parkinson disease in Chinese patients

Abstract: Supplemental Digital Content is available in the text

Cited by 54 publications

References 31 publications

Predictors of freezing of gait in Chinese patients with Parkinson's disease

Predictors of freezing of gait in Chinese patients with Parkinson's disease

Non-Motor Symptoms Assessed by Non-Motor Symptoms Questionnaire and Non-Motor Symptoms Scale in Parkinson's Disease in Selected Asian Populations

Clinical features and related factors of freezing of gait in patients with Parkinson's disease

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