A Prospective Study of Extending the Implanted Port Heparin Flushing Cycle in Outpatients with Solid Tumors

Kim, Hyekyung; Ku, Hyunkyung; Choi, So-eun

doi:10.7475/kjan.2018.30.2.216

Cited by 1 publication

(2 citation statements)

References 26 publications

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“…Through a comprehensive literature search, screening of titles and abstracts, finally14 articles with a total of 2488 participants (range 24–390) were included in our systematic review, 7,15–27 see Figure 1 and Table 1. All four cohort studies included were of high quality.…”

Section: Resultsmentioning

confidence: 99%

“…However, it’s worth noting that flush fluid and interval varied across studies which may be the sources of clinical heterogeneity. Of the included trials, eight 7,17–20,22,24,25 performed flush procedures using normal saline followed by heparin, three trials 15,21,23 performed flush only by heparin, and two 26,27 trials performed flush only by normal saline. Although, the Infusion Therapy Standards of Practice (eighth edition, revised 2021) by the Infusion Nurses Society recommended that normal saline solution and heparin had the same locking effect.…”

Section: Discussionmentioning

confidence: 99%

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Prolonged flushing and locking interval for totally implantable vascular access device: A systematic review and meta-analysis

Xiong

Zhou

2021

J Vasc Access

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The objective of this systematic review is to evaluate the safety ad feasibility of the totally implantable vascular access devices (TIVADs) flushed more than 4 weeks. We searched the following electronic databases from the date their build-up to February 2020: PubMed, EMBASE, The Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL. The final selection resulted in 14 trials fulfilling the inclusion criteria and being included in our review. A pooled frequency of port-related late complications with longer flushing intervals (>4 weeks) was 8.0%, and the pooled frequency of occlusions, infections, and mechanical complications was 5.0%, 2.0%, and 3.0%, respectively. Then, we compared the frequency of port-related complications between standard and longer flushing intervals. There were no differences between the group’s changes in the frequency of total late complications, occlusions, infections, and mechanical complications. This systematic review and meta-analysis demonstrates that longer flushing intervals for ports are safe. However, more prospective, power appropriated randomized trials are needed to explore the specific flushing time for ports.

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