A prospective study of body mass index and mortality in Bangladesh

Pierce, Brandon L.; Kalra, Tara; Argos, Maria; Parvez, Faruque; Chen, Yu; Islam, Tariqul; Ahmed, Alauddin; Hasan, Rabiul; Rakibuz-Zaman, Muhammad; Graziano, Joseph H.; Rathouz, Paul J.; Ahsan, Habibul

doi:10.1093/ije/dyp364

Cited by 57 publications

(57 citation statements)

References 31 publications

(35 reference statements)

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“…Therefore, we expect that the noise introduced by this weight measuring protocol would not be systematic, and would not result in confounding between genetics and body mass index. A previous study of BMI and mortality on a subset of the same study population was associated with other clinical endpoints in the expected manner [4]. Therefore we have confidence that the BMI we measured accurately captures the BMI of this population.…”

Section: Discussionsupporting

confidence: 52%

Genome-Wide Association Studies and Heritability Estimates of Body Mass Index Related Phenotypes in Bangladeshi Adults

et al. 2014

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Many health outcomes are influenced by a person's body mass index, as well as by the trajectory of body mass index through a lifetime. Although previous research has established that body mass index related traits are influenced by genetics, the relationship between these traits and genetics has not been well characterized in people of South Asian ancestry. To begin to characterize this relationship, we analyzed the association between common genetic variation and five phenotypes related to body mass index in a population-based sample of 5,354 Bangladeshi adults. We discovered a significant association between SNV rs347313 (intron of NOS1AP) and change in body mass index in women over two years. In a linear mixed-model, the G allele was associated with an increase of 0.25 kg/m2 in body mass index over two years (p-value of 2.3·10−8). We also estimated the heritability of these phenotypes from our genotype data. We found significant estimates of heritability for all of the body mass index-related phenotypes. Our study evaluated the genetic determinants of body mass index related phenotypes for the first time in South Asians. The results suggest that these phenotypes are heritable and some of this heritability is driven by variation that differs from those previously reported. We also provide evidence that the genetic etiology of body mass index related traits may differ by ancestry, sex, and environment, and consequently that these factors should be considered when assessing the genetic determinants of the risk of body mass index-related disease.

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Section: Discussionsupporting

confidence: 52%

Genome-Wide Association Studies and Heritability Estimates of Body Mass Index Related Phenotypes in Bangladeshi Adults

et al. 2014

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“…At the same time the ADA has defined BMI cutoffs for screening for diabetes for Asian Americans, as well as India and other Asian countries ( Japan, China) 37,38 have lowered BMI cut-points to define overweight and obesity based on available data, many would still argue that BMI should only be defined according to overall mortality, particularly when some studies in South Asians have not shown inordinately high mortality at BMI cut-points ‡23 kg/m 2 . 39,40 Time and again, validity of ''health guidelines'' have been questioned because of lack of robust data, particularly in the context of mortality. Could ''less than perfect'' data be enough to make guidelines for improving public health?…”

Section: Ethnicity and Bmi: Contentious Issuesmentioning

confidence: 99%

Ethnic-Specific Criteria for Classification of Body Mass Index: A Perspective for Asian Indians and American Diabetes Association Position Statement

Misra

2015

Diabetes Technology & Therapeutics

200

130

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Definitions for overweight and obesity are universally applied using body mass index (BMI), based on morbidity and mortality data derived from white populations. However, several studies have shown higher body fat, excess metabolic perturbations, and cardiovascular risk factors at lower value of BMI in Asian versus white populations. Definitive guidelines have been published to classify a BMI of ‡23 kg/m 2 and ‡25 kg/m 2 as overweight and obese, respectively, by the Indian Consensus Group (for Asian Indians residing in India) and a BMI of ‡23 kg/m 2 for screening for diabetes by the National

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“…Therefore weight loss (very low BMI) resulting from existing illness may distort the relationship. However, while exploring associations between low BMI and increased mortality in a cohort, Pierce et al did not find any role of possible confounding by co-morbidity (32) . Third, the BDHS 2011 did not collect information on tobacco smoking habits at the individual level (only collected information on second-hand smoke at household level).…”

Section: Discussionmentioning

confidence: 95%

Hypertension and diabetes prevalence among adults with moderately increased BMI (23·0–24·9 kg/m²): findings from a nationwide survey in Bangladesh

Rahman

Williams

Mamun

2017

Public Health Nutr.

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Objective: BMI is a proxy for fat accumulation in the body. Increased diabetes and CVD risks have been observed for Asian populations at lower BMI than the WHO-recommended BMI cut-off points for overweight (≥25·0 kg/m 2 ) and obesity (≥30·0 kg/m 2 ). The current study aimed to quantify the increased hypertension (HTN) and type 2 diabetes mellitus (T2DM) prevalence in Bangladeshi adults with moderately increased BMI (23·0-24·9 kg/m 2 ). Design: Data from the most recent Bangladesh Demographic and Health Survey (2011) were analysed. Modified Poisson regression models with robust error variance were used to calculate prevalence ratios (PR) for HTN or T2DM by BMI category, considering BMI = 18·5-22·9 kg/m 2 as the reference. All analyses incorporated the complex sampling design of the survey. Setting: BMI, blood pressure, blood sugar and related information were collected from a nationally representative sample. Subjects: Adults (n 7433) aged ≥ 35 years. Results: About 12 % of Bangladeshi adults, both male and female, were within the BMI range 23·0-24·9 kg/m 2 or moderately overweight. Compared with the reference BMI group (18·5-22·9 kg/m 2 ), they had an increased PR for HTN (1·55-1·77) and T2DM (1·54-1·93). These increased PR are similar to those for the WHO-defined overweight group (BMI = 25·0-29·9 kg/m 2 ). Conclusions: Our findings support the recommendation that calls for setting the optimum BMI for Asian populations to 18·5-23·0 kg/m 2 for health promotion and for public health interventions like leisure-time physical activity. WHO cut-off points for overweight (≥25 kg/m 2 ) should be used to facilitate international comparisons.

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A prospective study of body mass index and mortality in Bangladesh

Abstract: Underweight (presumably due to malnutrition) is a major determinant of mortality in the rural Bangladeshi population.

Cited by 57 publications

References 31 publications

Genome-Wide Association Studies and Heritability Estimates of Body Mass Index Related Phenotypes in Bangladeshi Adults

Genome-Wide Association Studies and Heritability Estimates of Body Mass Index Related Phenotypes in Bangladeshi Adults

Ethnic-Specific Criteria for Classification of Body Mass Index: A Perspective for Asian Indians and American Diabetes Association Position Statement

Hypertension and diabetes prevalence among adults with moderately increased BMI (23·0–24·9 kg/m²): findings from a nationwide survey in Bangladesh

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A prospective study of body mass index and mortality in Bangladesh

Abstract: Underweight (presumably due to malnutrition) is a major determinant of mortality in the rural Bangladeshi population.

Cited by 57 publications

References 31 publications

Genome-Wide Association Studies and Heritability Estimates of Body Mass Index Related Phenotypes in Bangladeshi Adults

Genome-Wide Association Studies and Heritability Estimates of Body Mass Index Related Phenotypes in Bangladeshi Adults

Ethnic-Specific Criteria for Classification of Body Mass Index: A Perspective for Asian Indians and American Diabetes Association Position Statement

Hypertension and diabetes prevalence among adults with moderately increased BMI (23·0–24·9 kg/m2): findings from a nationwide survey in Bangladesh

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Hypertension and diabetes prevalence among adults with moderately increased BMI (23·0–24·9 kg/m²): findings from a nationwide survey in Bangladesh