A Prospective Study of Alcohol Consumption and Smoking and the Risk of Major Gastrointestinal Bleeding in Men

Strate, Lisa L.; Singh, Prashant; Boylan, Matthew R.; Piawah, Sorbarikor; Cao, Yin; Chan, Andrew T.

doi:10.1371/journal.pone.0165278

Cited by 35 publications

(22 citation statements)

References 52 publications

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“…26 One prospective study including 48,000 men did not find an increased risk of major gastrointestinal bleeding among current or past smokers or in relation to pack-years of smoking. 27 However, another prospective including 5,888 elderly men and women found that current smokers had a higher risk of hospitalization for gastrointestinal bleeding than non-smokers. 28 To the best of our knowledge, no studies have examined the association between smoking and airway bleeding.…”

Section: Discussionmentioning

confidence: 99%

Smoking is Associated with Increased Risk of Major Bleeding: A Prospective Cohort Study

Langsted

Nordestgaard

2018

Thromb Haemost

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Background Tobacco smoking represents the most preventable cause of several fatal and disabling diseases worldwide. Several ingredients in tobacco have been suspected to cause changes in the arterial wall leading to instability of blood vessels. The association of smoking with major bleeding is largely unexplored. We tested the hypothesis that smoking and high tobacco consumption are associated with increased risk of bleeding. Materials and Methods This is a prospective cohort study with a mean follow-up of 5.9 years including 99,359 individuals from the Copenhagen General Population Study, with a questionnaire including self-reported smoking status and information on smoking intensity in cigarettes per day and pack-years. In this study, 17,555 were current smokers, 40,182 former smokers and 41,622 were never smokers. Results Multivariable adjusted hazard ratios for current smokers versus never smokers were 1.49 (95% confidence interval [CI]: 1.38–1.61) for any major bleeding, 1.71 (1.37–2.13) for intracranial bleeding, 1.35 (1.14–1.60) for airway bleeding, 2.20 (1.84–2.62) for gastrointestinal bleeding and 1.39 (1.26–1.55) for urinary bleeding. Increased smoking intensity was also associated with increased risk of any major bleeding, where > 40 pack-years in current and former smokers compared with never smokers had a multivariable adjusted hazard ratio of 1.59 (95% CI: 1.45–1.73) (p for trend across four groups: < 0.001). Also, current smokers smoking > 20 cigarettes per day compared with former and never smokers had a corresponding hazard ratio of 1.67 (1.51–1.85) (p for trend across four groups: < 0.001). Conclusion Current smokers have an increased risk of any major bleeding as well as of intracranial, airway, gastrointestinal and urinary bleeding. Also, increased smoking intensity was associated with increased risk of major bleeding.

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Section: Discussionmentioning

confidence: 99%

Smoking is Associated with Increased Risk of Major Bleeding: A Prospective Cohort Study

Langsted

Nordestgaard

2018

Thromb Haemost

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“…Other studies suggest that alcohol consumption is typically associated with increased risk of GIB, particularly from peptic ulcer disease. 19 In the prospectively collected database, which incorporates details from other institutions' records, GIB patients were more likely to be anemic, have a coagulopathy, be malnourished, and have a chemical dependency. This is associated with known risk factors for GIB, which include non-GI comorbidities.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Bleed After Total Pancreatectomy With Islet Autotransplant

Robbins¹,

Lusczek²,

Bellin

et al. 2021

Pancreas

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Objective: Gastrointestinal bleeding (GIB) is an uncommon complication after abdominal surgery. Given the unique risks in the total pancreatectomy with islet autotransplant (TPIAT) population, we aimed to describe this population's incidence of postoperative GIB.Methods: Prospectively collected data on patients who underwent a TPIAT from 2001 to 2018 at the University of Minnesota were reviewed for postoperative GIB. Each GIB patient was matched to a control patient and compared for medical, medication, and social history and for clinical outcomes.Results: Sixty-eight patients developed a GIB (12.4%) at median time after surgery of 17 months. Etiologies included the following: anastomotic ulcer (35%), Clostridium difficile (4%), gastric or duodenal ulcers (9%), esophagitis/gastritis (10%), hemorrhoids (3%), inflammatory bowel disease (4%), Mallory-Weiss tears (1%), and unknown (29%). During diagnostic workup, 87% had an endoscopic procedure and 3% underwent imaging. Seven patients required an operation (10%), 1 required an open embolization (1%), and 13 required endoscopic treatments (19%). Patients with a GIB were more likely to die (15% vs 5%, P = 0.055).Conclusions: Twelve percent of patients developed a GIB after TPIAT.One third of those had an undefined etiology despite endoscopy. The need for intervention was high (30%).

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“…Emergency laparoscopic patch repair was undertaken, and he made an uneventful recovery, with referral to alcohol dependence services. Risk factors for peptic ulcerative disease include helicobacter pylori infection (48%), 1 NSAID use (24%), 1 smoking (23%), 1 and alcohol excess (43%), 2 which was likely an important contributing factor in this patient.…”

Section: Case Descriptionmentioning

confidence: 95%

A man with an alcoholic‐related duodenal perforation after losing his job due to the SARS‐COV‐2 pandemic

Mahdi

Ali

2021

Clinical Case Reports

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A Prospective Study of Alcohol Consumption and Smoking and the Risk of Major Gastrointestinal Bleeding in Men

Cited by 35 publications

References 52 publications

Smoking is Associated with Increased Risk of Major Bleeding: A Prospective Cohort Study

Smoking is Associated with Increased Risk of Major Bleeding: A Prospective Cohort Study

Gastrointestinal Bleed After Total Pancreatectomy With Islet Autotransplant

A man with an alcoholic‐related duodenal perforation after losing his job due to the SARS‐COV‐2 pandemic

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