A Prospective Study of Adherence to Glatiramer Acetate in Individuals with Multiple Sclerosis*

Fraser, Cira; Morgante, Linda; Hadjimichael, Olympia; Vollmer, Timothy

doi:10.1097/01376517-200406000-00002

Cited by 51 publications

(35 citation statements)

References 19 publications

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“…Studies included in this review varied in terms of the patient population, with 11 studies examining patients with RRMS only, 16,23,[25][26][27][28][29][30][31][32][33] 12 studies examining patients with any form of MS, 17,18,[34][35][36][37][38][39][40][41][42][43] and only 1 study examining the progressive form of the disease exclusively. 44 Among studies reporting time since MS diagnosis, mean time since diagnosis ranged between 2 and 12 years.…”

Section: ■■ Resultsmentioning

confidence: 99%

“…All prospective studies included patients who were already on some form of DMT prior to assessing adherence (mean years on therapy ranged from 2 to 6 years across studies). [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39]44 Three retrospective studies evaluated adherence specifically among those initiating a DMT, 17,40,42 while the remaining 5 either did not specify prior treatment or included patients who had already received treatment with a DMT. 16,18,41,43 There were 6 different measures used in the literature to measure patient adherence, including 2 variations of the medication possession ratio (MPR; used among 11 studies), the missed dose ratio (MDR; 3 studies), total number of missed doses (2 studies), percentage of days not covered by therapy (2 studies), and no missed doses over a pre-specified time period (7 studies).…”

Section: ■■ Resultsmentioning

confidence: 99%

“…Several studies have pointed to specific patient populations that are at high risk of nonadherence, including patients with high injection anxiety, mental illness, lower perceptions of injection self-efficacy (i.e., the ability to self-inject), or the misconception that the drug is not working for them because they do not see immediate or daily benefits from injections. [28][29][30]33,34,36,39,44 The implementation of targeted disease therapy management programs may help to improve adherence among these patients. We identified 2 studies in the recent literature that concluded that use of disease therapy management or interventional programs among broader (nontargeted) cohorts of patients with MS have improved patient adherence to DMTs.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Narrative Review of the Literature on Adherence to Disease-Modifying Therapies Among Patients with Multiple Sclerosis

Menzin¹,

Caon²,

Nichols³

et al. 2013

JMCP

181

188

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Section: ■■ Resultsmentioning

confidence: 99%

Section: ■■ Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Narrative Review of the Literature on Adherence to Disease-Modifying Therapies Among Patients with Multiple Sclerosis

Menzin¹,

Caon²,

Nichols³

et al. 2013

JMCP

181

188

View full text Add to dashboard Cite

“…The improvement of self-care ability is important in treatment of a chronic disease such as diabetes, and it increases the quality of life in diabetics (Fraser et al, 2004 should be taken into account because some studies consider the lack of daily self-care as the most important cause of mortality in diabetics (Halipchuk et al, 2017). Therefore, it is important to stimulate the self-care in these patients and use this potential (Afshar & Izadi, 2005).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Self-Care Education through Social Networks on the Patients’ Quality of Life with Type 1 Diabetes in Sanandaj City, Iran

Mohammadi¹,

Valiee²,

Nouri³

et al. 2018

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Introduction and Objective: The increasing advances in technology and development of the Internet and telecommunications have provided great opportunities for the healthcare and distance education. The present study aimed to examine the impact of distance education (through virtual social networks) on the quality of life in type-1 diabetic patients referring to the diabetes clinic of Tohid Hospital in Sanandaj. Materials and Methods: The present study was a clinical trial with a registration number of IRCT2017 092336362N1. In the spring of 2017, 80 patients were selected from type-1 diabetic patients, who referred to diabetes clinic of Tohid Hospital in Sanandaj, and they were randomly put into 35-patient experimental group, and the 45-patient control group. The quality of life questionnaire and the subjects' demographic characteristics were collected before the research. In the studied group, training was completed for two months by creating a telegram channel. After two months, the questionnaires were re-completed in both groups. Results: Both intervention and control groups were similar in terms of numerical demographic variables such as age and educational status, and also in terms of variables such as the gender, marital status, family history, insurance, weight and height. Before the research, the mean score of quality of life in the intervention group was equal to 40.82, but it was 43.34 after the research. Despite the fact that this value was not statistically significant (p = 0.0638), the mean score of their quality of life increased. In the control group, there was not any significant difference between the quality of life scores before and after the intervention (p = 0.6147). Conclusion: Self-care distance education in Creative Education diabetic patients could have a significant effect on the improved patient self-care and ultimately increase the mean score of patients' quality of life. The use of social networks in providing this education could provide free education on a wide scale for a wide range of these patients, and on the other hand, it could reduce the educational inequalities and provide education for remote areas.

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“…According to Bandura, self-efficacy is the highest predictive factor of perseverance in a new behavior. There is considerable evidence that higher selfefficacy is related to greater persistence in diverse contexts ranging from health recommendations for management of diabetes and rheumatoid arthritis, to exercise and smoking cessation programs, to medication taking in a variety of diseases such as epilepsy, HIV, post-transplantation [15] and RRMS [4,16].…”

Section: Self-efficacymentioning

confidence: 99%

Examining the Influence of Behavioral Factors on Compliance and Persistence with Glatiramer Acetate Injection for Relapsing-Remitting Multiple Sclerosis

Oleen-Burkey¹,

Pardo²

2014

J Neurol Neurophysiol

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Objective: To evaluate the relationship between compliance and persistence with glatiramer acetate (GA) and the behavioral variables in the transtheoretical model of change. Methods:Patients diagnosed with relapsing-remitting multiple sclerosis and being treated with GA for the first time, whether treatment-naïve (TN) or treatment-experienced (TE), were eligible for this prospective, observational, 12-week study. Institutional Review Board approval was obtained for each of 32 US study sites, and written informed consent was obtained for all patients prior to study procedures. Four office visits were required. Study procedures included baseline self-injection training and patient-reported behavioral variable surveys. Injection competence and medication compliance and persistence were assessed at weeks 4 and 12.Results: A total of 257 patients were enrolled; 80.9% were female, 81.6% white, and 60.0% TN. The evaluable population included 146 TN patients and 88 TE patients having discontinued beta-interferons. TE patients were at a significantly higher readiness stage, were less concerned about the negative aspects of self-injection, but had lower levels of MS self-efficacy than TN patients. While compliance and persistence rates did not differ between TN and TE groups, there were differences in outcome predictors. For the TN patients both higher self-injection competence at baseline and improvement in self-injection competence over the first month of therapy were predictive of better compliance and persistence with GA. Separate from injection competence, higher levels of functional self-efficacy were directly associated with better persistence in TN patients. None of the behavioral variables appeared to predict compliance or persistence for the TE patients. Conclusion:Among the TN, injection competency at baseline and improvement over the first month of use were significant predictors of compliance and persistence to GA at 12 weeks.Improving self-injection competence should be a priority when planning interventions for TN patients. Behavioral factors predicting compliance and persistence among TE patients require further study. ClinicalTrials.gov (number NCT00238654)

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A Prospective Study of Adherence to Glatiramer Acetate in Individuals with Multiple Sclerosis*

Cited by 51 publications

References 19 publications

Narrative Review of the Literature on Adherence to Disease-Modifying Therapies Among Patients with Multiple Sclerosis

Narrative Review of the Literature on Adherence to Disease-Modifying Therapies Among Patients with Multiple Sclerosis

The Effect of Self-Care Education through Social Networks on the Patients’ Quality of Life with Type 1 Diabetes in Sanandaj City, Iran

Examining the Influence of Behavioral Factors on Compliance and Persistence with Glatiramer Acetate Injection for Relapsing-Remitting Multiple Sclerosis

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