A Prospective Study in the Evaluation of Quality of Life After Vulvar Cancer Surgery

Nováčková, Marta; Halaška, Michael; Robová, Helena; Malá, Ivana; Pluta, Marek; Chmel, Roman; Rob, Lukáš

doi:10.1097/igc.0000000000000313

Cited by 31 publications

(22 citation statements)

References 21 publications

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“…When quality of life was evaluated with the FACT-V questionnaire, results were significantly worse for the functional scale and for the edema, complaints, and need for use of compression stockings. Novackova et al observed worse fatigue and lymphedema in patients undergoing full inguinofemoral lymphadenectomy than in those undergoing SLN biopsy [24]. Forner et al found that inguinofemoral lymphadenectomy had a negative impact on sexual function [25].…”

Section: What Is the Relationship Between Findings On Sln And Survival?mentioning

confidence: 97%

Update on sentinel lymph node biopsy for early-stage vulvar cancer

Slomovitz

Coleman

Oonk

et al. 2015

Gynecologic Oncology

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Section: What Is the Relationship Between Findings On Sln And Survival?mentioning

confidence: 97%

Update on sentinel lymph node biopsy for early-stage vulvar cancer

Slomovitz

Coleman

Oonk

et al. 2015

Gynecologic Oncology

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“…18, 23 Gunther et al 24 found decreased sexual activity in women treated with vulvectomy compared with women treated with WLE (16% vs 43%), whereas 3 other studies assessing changes in sexual activity over time and across surgical methods were not able to detect differences regardless of the questionnaire used (FACT-V, FSFI, EORTC QLQ-CX24; Tables 2 and 3). 20,21,26 Two studies identified significantly decreased desire and arousal, 18 and more problems with dyspareunia and ability to achieve orgasm in VC patients compared with healthy control women 23 using selfdesigned nonvalidated questionnaires (Table 2). Significant deterioration of general SXF over time before and after the treatment in VC patients was reported in 2 studies, assessed by self-designed nonvalidated questionnaire and the general sex life domain of the ePAQ-PF (Tables 2 and 3).…”

Section: Sexual Functionmentioning

confidence: 99%

Assessing Patient-reported Quality of Life Outcomes in Vulva Cancer Patients: A Systematic Literature Review

Froeding

Greimel

Lanceley

et al. 2018

Int J Gynecol Cancer

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“…Another publication prospectively looked at the quality of life after inguinal surgery [29] and authors found a clear benefit for a less radical approach.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Outcome after Sentinel Lymph Node Biopsy or Inguinal Lymph Node Dissection in Patients with Nodal Negative Squamous Vulvar Cancer

Ebner¹,

Antje²,

Schramm³

et al. 2017

Glob Surg

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Sentinel lymph node biopsy (SLNB) can reduce postoperative morbidity in women with vulvar cancer but data on long-term outcome of SLNB compared to inguinal lymph node dissection (ILND) is rare. Recurrence rates, disease-free survival (DFS) and overall survival (OS) from pT1/T2 pN0 squamous vulvar cancer from 1992 -2011 were retrospectively compared between patients with SLNB (n=56) or ILND (n=56). PT2 tumors (59% vs. 11%; p<0.001) and complete vulvectomy (39% vs. 4%; p < 0.001) occured more often in the ILND than the SLNB group with no difference in lymph node recurrence rate. Multivariate survival analysis considering the year of primary diagnosis, tumor stage and surgery revealed no significant effect of treatment on DFS (p=0.062) or OS (p=0.924). SLNB seems to be a safe treatment for women with pT1/T2 nodal-negative vulvar cancer with no difference in DFS or OS compared to ILND. Those results confirm the results of the GROINSS-V Study and other literature with the longest follow-up data reported within a real-life collective. Impact statementSLNB has been shown to reduce postoperative morbidity in women with vulvar cancer, however, data on long-term outcome of SLNB in vulvar cancer is rare. The aim of this study was to evaluate the outcome of patients with nodal-negative vulvar cancer that had undergone either SLNB or ILND in a clinical collective. Patients in the ILND group presented with more pT2 tumors (59% vs. 11%; p< 0.001) and followed by complete vulvectomy (39% vs. 4%; p <0.001). The lymph node recurrence rate was not significantly different between both groups (p=0.57). A multivariate survival analysis accounting for year of primary diagnosis, tumor stage and type of surgery revealed no significant effect of treatment on DFS or OS. SLNB seems to be a safe treatment for women with T1/T2 nodal-negative vulvar cancer, as we observed no difference in DFS or OS compared to patients with ILND. However, because of the observed bias between the two groups, results have to be interpreted carefully and need to be confirmed in larger prospective trials. Nevertheless, the results represent further data regarding the oncological safety of SNB supporting current literature and strongly underlie its value in the described setting with the longest follow-up, to date, reported.

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A Prospective Study in the Evaluation of Quality of Life After Vulvar Cancer Surgery

Abstract: Less radical surgery showed objectively better QoL results.

Cited by 31 publications

References 21 publications

Update on sentinel lymph node biopsy for early-stage vulvar cancer

Update on sentinel lymph node biopsy for early-stage vulvar cancer

Assessing Patient-reported Quality of Life Outcomes in Vulva Cancer Patients: A Systematic Literature Review

Comparison of Outcome after Sentinel Lymph Node Biopsy or Inguinal Lymph Node Dissection in Patients with Nodal Negative Squamous Vulvar Cancer

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