A prospective study in children: Pre- and post-surgery use of vitamin E in surgical incisions

Zampieri, Nicola; Zuin, Veronica; Burro, Roberto; Ottolenghi, A.; Camoglio, Francesco Saverio

doi:10.1016/j.bjps.2009.08.018

Cited by 55 publications

(36 citation statements)

References 25 publications

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“…48 In addition, it has been found that palm vitamin E extract, which contains a mixture of 60% tocotrienol and 40% tocopherol, enhances wound healing in diabetic rats and increases the activity of the GPx enzyme. 49 Consistent with our finding Arnold and Barbul 47 and Burgess 46 indicated that vitamin E supplementation is beneficial to wound healing, 50 and topical vitamin E has been widely promoted as an anti-scarring agent and Zampieri et al 51 also showed that topical application of vitamin E could improve the cosmetic results of surgical incisions. Topical formulations of vitamin E have been promoted to help wound healing, presumably because they inhibit collagen synthesis and reduce both fibroblast proliferation and inflammation.…”

Section: Discussionsupporting

confidence: 83%

Cutaneous Wound Healing after Topical Application of <i>Pistacia atlantica</i> Gel Formulation in Rats

Hamidi

Naeini

Oryan

et al. 2017

tjps

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ÖZAmaç: Bu çalışma, sıçanlarda oluşturulan deneysel yara modelinde Pistacia atlantica yağı ile hazırlanmış jel formülasyonunun, enzimatik antioksidanlar üzerindeki etkisini araştırmak amacıyla yapılmıştır. Gereç ve Yöntemler: Genel anestezi altına alınan hayvanlarda, aseptik koşullarda, insizyon yapmak suretiyle kare şeklinde yaralar (2x2 cm) oluşturulmuştur. Daha sonra, hayvanlar rasgele dört gruba ayrılmıştır (I-tedavi edilmemiş kontrol grubu, II-haricen uygulanan baz jel grubu, IIIharicen %5 jel uygulanan grup, IV-haricen %10 jel uygulanan grup). Bulgular: Sonuçlar, Pistacia atlantica yağı ile hazırlanmış jel formülasyonunun haricen uygulanmasının, kontrol ve baz jel gruplarına kıyasla, bütünlüğü bozulmamış stratum bazalisi, olgun granülasyon dokusunu, kıl folikülleri ve ter bezleri ile reepitelizasyonu arttırdığını göstermektedir. Yara oluşumundan 21 gün sonra, %10 yağlı jel ile tedavi edilen hayvanların dokularındaki gerilme kuvveti, kopma gerilimi ve bükülme direnci, kontrol ve baz jel grubu ile karşılaştırıldığında önemli ölçüde artmıştır. Aynı evredeki kontrol ve baz jel ile muamele edilen gruplara kıyasla, kollajen liflerin daha organize bir düzenlenme ve dokunun daha düzgün bir iyileşme gösterdiği belirlenmiştir. Sonuç: Pistacia atlantica yağ jelinin haricen uygulanmasının, sıçanlarda oluşturulan deneysel yaralar üzerinde morfolojik, biyokimyasal ve biyomekanik yönden düzeltici rol oynadığı ortaya koyulmuştur. Anahtar kelimeler: Pistacia atlantica, yara iyileşmesi, histopatoloji, biomekanik, deri Objectives: This study has been undertaken to investigate the antioxidant activity of the gel formulation from Pistacia atlantica oil extraction on enzymatic antioxidants in experimental wound created in rats. Materials and Methods: Under anesthesia, a square-shaped skin defect (2x2 cm) was created aseptically by surgical incision. Then, animals were randomly allocated to four groups (I-untreated controls, II-topically treated with base gel, III-topically treated with 5% gel, IV-topically treated with 10% gel). Results:The results suggest that topical application of Pistacia atlantica oil gels improved reepithelialization with continuous stratum basalis and a mature granulation tissue and adnexa (hair follicles and sweat gland) compared with control and base gel groups. Treatment with 10% oil gel significantly enhanced the tensile strength, ultimate stress, yield strength and stiffness in this group compared with the control and base gel groups at 21 days post injury. The collagen fibers showed a more organized pattern and the tissue alignment was greater as compared to the control and base gel-treated groups at the same stage. Conclusion:The results suggest that topical application of Pistacia atlantica oil gel improved the morphological, biochemical and biomechanical properties of experimentally-induced wound defects in rats.

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Section: Discussionsupporting

confidence: 83%

Cutaneous Wound Healing after Topical Application of <i>Pistacia atlantica</i> Gel Formulation in Rats

Hamidi

Naeini

Oryan

et al. 2017

tjps

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“…A recent study evaluated the role of topical vitamin E in the treatment of surgical incision wounds in children [27] . Children were either treated topically with petrolatum jelly as control or with a topical vitamin E formulation.…”

Section: Vitamin Dmentioning

confidence: 99%

Antioxidant Therapies for Wound Healing: A Clinical Guide to Currently Commercially Available Products

Fitzmaurice

Sivamani

Isseroff

2011

Skin Pharmacol Physiol

196

144

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Many facets of wound healing under redox control require a delicate balance between oxidative stress and antioxidants. While the normal physiology of wound healing depends on low levels of reactive oxygen species and oxidative stress, an overexposure to oxidative stress leads to impaired wound healing. Antioxidants are postulated to help control wound oxidative stress and thereby accelerate wound healing. Many antioxidants are available over the counter or by prescription, but only one, Medihoney®, has been specifically FDA approved for wound healing. Here we review the existing evidence for the use of antioxidants for wound healing, with a review of the pertinent animal and clinical studies. Natural products and naturally derived antioxidants are becoming more popular, and we specifically review the evidence for the use of naturally derived antioxidants in wound healing. Antioxidant therapy for wound healing is promising, but only few animal studies and even fewer clinical studies are available. Because only few products have undergone FDA approval, the consumer is advised to scrutinize them for purity and contaminants prior to use, and this may require direct contact with the companies that sell them. As a field of science, the use of antioxidants for wound healing is in its infancy, and future studies will better elucidate the role of antioxidants in wound healing.

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“…Subsequent studies have demonstrated the effectiveness of using diapers with a continuous release of a combination of zinc oxide and petrolatum [10,11]. In the literature, the properties of tocopherol have been analyzed many times in the treatment of skin diseases in the newborn, and in the treatment of surgical wounds with pre and post-surgery administration either as regards the management of lesions or the maceration of the skin due to the rubbing on the surface of the diaper or to stagnation of material such as feaces and urine in the most prone area to the onset of dermatitis [12].…”

Section: Discussionmentioning

confidence: 99%

Zinc Oxide 30% and Tocopherol Compared to 10% Zinc Oxide Ointment in the Treatment of Infant's Diaper Dermatitis: A Triple Blinded Controlled Randomized Trial

Tosin¹,

Bonaldi²,

Dell’orletta³

et al. 2017

Clin Pediatr Dermatol

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A prospective study in children: Pre- and post-surgery use of vitamin E in surgical incisions

Cited by 55 publications

References 25 publications

Cutaneous Wound Healing after Topical Application of <i>Pistacia atlantica</i> Gel Formulation in Rats

Cutaneous Wound Healing after Topical Application of <i>Pistacia atlantica</i> Gel Formulation in Rats

Antioxidant Therapies for Wound Healing: A Clinical Guide to Currently Commercially Available Products

Zinc Oxide 30% and Tocopherol Compared to 10% Zinc Oxide Ointment in the Treatment of Infant's Diaper Dermatitis: A Triple Blinded Controlled Randomized Trial

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