A prospective study comparing hemoglobin levels and response in patients of locally advanced carcinoma cervix receiving accelerated chemoradiation versus conventional chemoradiation

Vias, Poorva; Angural, Harpreet; Seam, Rajeev Kumar; Gupta, Manoj Kumar; Gupta, Manish; Fotedar, Vikas; Negi, Anup

doi:10.4103/jrcr.jrcr_17_19

Cited by 2 publications

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“…Os autores sugerem que novos estudos são necessários para avaliar o efeito da HB nos desfechos de sobrevida, além do impacto do uso de eritropoietina e transfusões de sangue como terapia de apoio para otimização da terapia radioterápica para pacientes com câncer de colo do útero. (VIAS, P. et al, 2019).…”

Section: Resultsunclassified

Anemia como fator preditivo negativo de resposta ao tratamento do câncer de colo uterino / Anemia as a negative predictive factor for response to treatment of cervical cancer

Viana¹,

Oliveira²,

Fernandes³

et al. 2021

BJDV

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Introdução: No Brasil, o câncer cervical (CC) é o terceiro tumor maligno mais frequente nas mulheres e a quarta causa de morte por câncer entre a população feminina, de acordo com o Instituto Nacional do Câncer (INCA). O agrupamento TNM, o tipo e grau histológico, a invasão linfovascular e/ou perineural são fatores prognósticos independentes, assim como a anemia. Objetivos: O presente estudo analisou o risco de óbito no primeiro ano de seguimento oncológico após término da radioterapia, conforme nível de hemoglobina (HB) pré tratamento (<10g/dl vs ≥10g/dl). Método: Estudo tipo coorte retrospectiva que incluiu pacientes com diagnóstico de CC, admitidas e tratadas em centro especializado de oncologia de Ipatinga -MG, Brasil no período de 2014 a 2017. Resultados: Pacientes com HB ≥ 10g/dl no pós tratamento apresentaram menor chance de evoluir para o óbito com relação às pacientes com HB < 10g/dl. 66,1% dos pacientes com HB ≥ 10g/dl no baseline foram classificados como livre da doença após término da radioterapia. O valor da HB após término da radioterapia também foi preditivo de resposta à radioterapia. Conclusão: A presença de HB < 10g/dl após término do tratamento correlacionou-se negativamente com tipo de resposta e risco de óbito.

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Section: Resultsunclassified

Anemia como fator preditivo negativo de resposta ao tratamento do câncer de colo uterino / Anemia as a negative predictive factor for response to treatment of cervical cancer

Viana¹,

Oliveira²,

Fernandes³

et al. 2021

BJDV

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The Importance of Hemoglobin Levels Before and During Chemoradiotherapy in Locally Advanced Carcinoma Cervix

Sequeira

Fernandes

Shankar

et al. 2021

Journal of Radiation and Cancer Research

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Purpose: Carcinoma cervix forms a major burden among malignancies in women in India. Anemia is very common among Indian women and a high proportion of carcinoma cervix patients present with anemia. Previous studies show that hemoglobin level may be considered as a prognostic factor in carcinoma cervix. It has been observed that anemia is associated with diminished radiocurability in patients with carcinoma of the cervix. However, the therapeutic benefit of the measures to correct anemia remains debatable. The objective of this study was to evaluate the association of hemoglobin concentrations and its correction by blood transfusions before and during treatment and the response to chemoradiation. Materials and Methods: Fifty patients with histologically proven squamous cell carcinoma of the cervix (Stage II to IV) from December 2018 to May 2020 were taken up for this study. Patients received definitive chemoradiation of 50 Gy in 25 fractions, 2 Gy/fraction, 5 fractions per week, along with-weekly injection cisplatin/carboplatin, followed by brachytherapy. All patients had their pretreatment hemoglobin levels measured at the first consultation. The effects of hemoglobin concentrations at presentation and during therapy on the clinical response to radiotherapy were studied. Blood transfusions and the time point when transfusions were given were recorded. Results: Eighteen patients received packed red blood cell transfusion before the start of radiation therapy and 9 patients received packed cell transfusion during radiation therapy. Out of the 18 patients who received transfusion before RT, 3 patients had complete response. Out of the 9 patients who received transfusion during radiation, 4 had complete response. The presence of anemia had a significant impact on the response rate. Pretreatment anemia was associated with poor response and local control among patients who underwent chemoradiotherapy for cervical cancer. Conclusion: Pretreatment hemoglobin and hemoglobin levels during radiation therapy were prognostic factors for local control, in addition to stage and histology, which might have independently predicted the outcome.

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A prospective study comparing hemoglobin levels and response in patients of locally advanced carcinoma cervix receiving accelerated chemoradiation versus conventional chemoradiation

Cited by 2 publications

References 1 publication

Anemia como fator preditivo negativo de resposta ao tratamento do câncer de colo uterino / Anemia as a negative predictive factor for response to treatment of cervical cancer

Anemia como fator preditivo negativo de resposta ao tratamento do câncer de colo uterino / Anemia as a negative predictive factor for response to treatment of cervical cancer

The Importance of Hemoglobin Levels Before and During Chemoradiotherapy in Locally Advanced Carcinoma Cervix

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