“…White et al reported the first dermatologic, aesthetic use of HIFU in 2008, and HIFU was approved by the food and drug administration in 2009 for use in brow lifting [18]. Currently, it is being used for facial rejuvenation, lifting, tightening, and body contouring, which are considered 'off-label' use [10]. The principle of HIFU is to induce cellular damage and volume reduction of the target area selectively by means of coagulation by generating instant microthermal lesions through the accumulation of high-frequency ultrasound beams at the specific tissue site without any damage to the epidermis and adjacent issue [21].…”