A Prospective, Single-Blind, Placebo-Controlled Trial of Bone Marrow Aspirate Concentrate for Knee Osteoarthritis

Shapiro, Shane A.; Kazmerchak, Shari E.; Heckman, Michael G.; Zubair, Abba C.; O’Connor, Mary I.

doi:10.1177/0363546516662455

Cited by 248 publications

(255 citation statements)

References 59 publications

(70 reference statements)

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“…Five studies evaluated cBMA in the treatment of knee osteoarthritis (OA) summarized in Table 3[20-24]. Only two studies evaluated the efficacy of cBMA without an adjunctive procedure.…”

Section: Resultsmentioning

confidence: 99%

“…Only two studies evaluated the efficacy of cBMA without an adjunctive procedure. One reported better clinical outcomes at one week and three months in patients who received cBMA but found no difference in these scores after six months[24]. One study reported significant clinical improvements but found that 76% of patients had abnormal International Cartilage Repair Society repair scores[23].…”

Section: Resultsmentioning

confidence: 99%

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Clinical application of concentrated bone marrow aspirate in orthopaedics: A systematic review

Gianakos¹,

Sun²,

Patel³

et al. 2017

WJO

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AIMTo examine the evidence behind the use of concentrated bone marrow aspirate (cBMA) in cartilage, bone, and tendon repair; establish proof of concept for the use of cBMA in these biologic environments; and provide the level and quality of evidence substantiating the use of cBMA in the clinical setting.METHODSWe conducted a systematic review according to PRISMA guidelines. EMBASE, MEDLINE, and Web of Knowledge databases were screened for the use of cBMA in the repair of cartilage, bone, and tendon repair. We extracted data on tissue type, cBMA preparation, cBMA concentration, study methods, outcomes, and level of evidence and reported the results in tables and text.RESULTSA total of 36 studies met inclusion/exclusion criteria and were included in this review. Thirty-one of 36 (86%) studies reported the method of centrifugation and preparation of cBMA with 15 (42%) studies reporting either a cell concentration or an increase from baseline. Variation of cBMA application was seen amongst the studies evaluated. Twenty-one of 36 (58%) were level of evidence IV, 12/36 (33%) were level of evidence III, and 3/36 (8%) were level of evidence II. Studies evaluated full thickness chondral lesions (7 studies), osteochondral lesions (10 studies), osteoarthritis (5 studies), nonunion or fracture (9 studies), or tendon injuries (5 studies). Significant clinical improvement with the presence of hyaline-like values and lower incidence of fibrocartilage on T2 mapping was found in patients receiving cBMA in the treatment of cartilaginous lesions. Bone consolidation and time to bone union was improved in patients receiving cBMA. Enhanced healing rates, improved quality of the repair surface on ultrasound and magnetic resonance imaging, and a decreased risk of re-rupture was demonstrated in patients receiving cBMA as an adjunctive treatment in tendon repair.CONCLUSIONThe current literature demonstrates the potential benefits of utilizing cBMA for the repair of cartilaginous lesions, bony defects, and tendon injuries in the clinical setting. This study also demonstrates discrepancies between the literature with regards to various methods of centrifugation, variable cell count concentrations, and lack of standardized outcome measures. Future studies should attempt to examine the integral factors necessary for tissue regeneration and renewal including stem cells, growth factors and a biologic scaffold.

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“…Five studies evaluated cBMA in the treatment of knee osteoarthritis (OA) summarized in Table 3[20-24]. Only two studies evaluated the efficacy of cBMA without an adjunctive procedure.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Clinical application of concentrated bone marrow aspirate in orthopaedics: A systematic review

Gianakos¹,

Sun²,

Patel³

et al. 2017

WJO

View full text Add to dashboard Cite

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“…As described by Hernigou et al [34] and later by Shapiro et al [35], briefly, appropriate local anesthesia of the skin and subcutaneous soft tissues should be administered. Then, a 1-cm stab incision was performed over iliac crest.…”

Section: Bone Marrowmentioning

confidence: 99%

“…An 11-gauge, 11-cm Jamshidi needle was used to aspirate the bone marrow. Effort was taken to use a parallel approach, with the needle directed parallel to the iliac wing between the inner and outer tables, and the needle was subsequently withdrawn and repositioned [34,35] (Figure 4). The marrow aspirates was then passed through a sterile filter into a separate compartment to remove particulate matter.…”

Section: Bone Marrowmentioning

confidence: 99%

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Mesenchymal Stem Cells for Optimizing Bone Volume at the Dental Implant Recipient Site

Ayna¹,

Gülses²,

Wiltfang³

et al. 2017

Mesenchymal Stem Cells - Isolation, Characterization and Applications

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Inadequate bone volume at the implant recipient site presents a clinical challenge for many dental practitioners. To overcome these problems, several approaches have been developed and are currently used, including bone grafting strategies and distraction osteogenesis. Mesenchymal stem cells (MSCs) have gained their popularity within the last two decades, with regard to promising clinical results in improving the bone architecture at the implant recipient site. The aim of this chapter was to briefly outline the accessibility properties, differentiation capacities, isolation, and characterization of MSCs with regard to optimizing bone volume in dental implantology. Additionally, potential benefits and pitfalls are discussed in comparison with the conventional bone augmentation techniques.

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Stem Cells and Their Application in Orthopedics

Li¹,

Zhu²,

Sun³

et al. 2022

Biofabrication for Orthopedics

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A Prospective, Single-Blind, Placebo-Controlled Trial of Bone Marrow Aspirate Concentrate for Knee Osteoarthritis

Cited by 248 publications

References 59 publications

Clinical application of concentrated bone marrow aspirate in orthopaedics: A systematic review

Clinical application of concentrated bone marrow aspirate in orthopaedics: A systematic review

Mesenchymal Stem Cells for Optimizing Bone Volume at the Dental Implant Recipient Site

Stem Cells and Their Application in Orthopedics

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