A prospective, randomized trial of nifedipine vs. ritodrine in threatened preterm labor

Garcia-Velasco, J. A.; González-González, Antonio

doi:10.1016/s0020-7292(98)00053-8

Cited by 69 publications

(35 citation statements)

References 20 publications

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“…In another study, no difference was found in Doppler measurement parameters (PI and RI) in UA before and 3 hours after drug application (15). In our study, we did not find any significant difference in Doppler ultrasonography parameters for UA, UtA, and MCA before and 2 hours (early) after nifedipine treatment.…”

Section: Discussioncontrasting

confidence: 75%

Comparison of effects of nifedipine and ritodrine on maternal and fetal blood flow patterns in preterm labor

Baykal¹,

Avcıoğlu²

2015

J Turkish German Gynecol Assoc

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Results:In both the groups, early-and late-onset changes in the pulsatility index (PI) and other Doppler indices for UA, UtA, and MCA were similar. In addition, time elapsed till delivery, fetal mortality, and maternal morbidity in both the groups were not statistically significant (p>0.05). However, maternal side effects such as tachycardia was more frequent (p<0.05) in the ritodrine group. Besides, in the ritodrine group, anxiety was only minimally observed. Conclusion:Nifedipine and ritodrine used as tocolytic agents did not significantly alter early-and late-onset changes in Doppler ultrasonography parameters in fetal and fetomaternal circulation. (J Turk Ger Gynecol Assoc 2015; 16: 80-5) Keywords: Doppler ultrasonography, tocolysis, umbilical artery, uterine artery, middle cerebral artery Received: 10 October, 2014 Accepted: 08 March, 2015 Comparison of effects of nifedipine and ritodrine on maternal and fetal blood flow patterns in preterm labor Abstract Metarial and MethodsSixty pregnant women, who applied to our clinic because of preterm labor and were aged between 18 and 44 years, were included. The subjects were enrolled after institutional ethic committee approval. Informed consent was obtained from all participants. The research was conducted in women who fulfilled the following admission criteria: pregnant with a single fetus of 24-36-week gestation; fetus with intact amniotic membranes; and experiencing two or more painful and persistent uterine contractions in 10 minutes, as established by tococardiography. These contractions could not be controlled after 2 hours of bed rest and resulted in changes in the cervix (at least 2 cm cervical dilatation and 75% ripening) (8,9). In all cases, fetal heart rates were recorded by ultrasonography or tococardiography. All patients included in the present study were in the latent phase of labor. Patients having cervical dilatation greater than 5 cm and effacement of 80% were not included in the present study. In addition, pregnant women with a concomitant morbidity such as heart, lung, or thyroid disease; high blood pressure; diabetes or infectious disease; an obstetric morbidity (e.g., pre-eclampsia, premature rupture of membranes, polyhydramniosis, gestational diabetes mellitus, intrauterine growth restriction, chorioanmionitis, or acute fetal distress); multiple pregnancies; or fetal malformations and patients who could not tolerate treatments were excluded from the present study. Demographic features and obstetric histories were recorded. Age, gravidity, parity, abortion, frequency of uterine contractions in 10 minutes, cervical dilatation, ripening parameters, and Bishop scores of patients were recorded. Fetal biometry and estimated fetal weight were evaluated via obstetric ultrasonography. Monitorization of uterine contractions and fetal cardiac activity were performed using a tococardiography device CMS 800G (Contec Medical System, China) or Wallach Sonicaid Team (Wallach Surgical devices, USA) for 20 minutes. Tocolysis was started when regular ...

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Section: Discussioncontrasting

confidence: 75%

Comparison of effects of nifedipine and ritodrine on maternal and fetal blood flow patterns in preterm labor

Baykal¹,

Avcıoğlu²

2015

J Turkish German Gynecol Assoc

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“…Various studies have compared ritodrine with nifedipine and found that both are equally effective in suppressing preterm labor but side effects were significantly less with nifedipine [8][9][10][11][12]. In our study also no significant difference was noted in maternal and neonatal side effects but less side effects were noted in nifedipine group.…”

Section: Discussionsupporting

confidence: 52%

Comparative Study of Nifedipine and Isoxpurine as Tocolytics for Preterm Labor

Singh

Seth

2011

J Obstet Gynecol India

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Objectives This study was done to compare isoxpurine hydrochloride and nifedipine as tocolytic drugs for preterm labor. Methods A prospective cohort study of 832 antenatal women with preterm labor was conducted in the Department of Obstetrics & Gynecology. Out of 400 women found eligible for tocolysis, 200 were given isoxpurine hydrochloride while the other 200 were given nifedipine randomly. The data obtained was statistically analyzed on SPSS 10.0 of Windows 2003. Results Incidence of preterm labor was 22% while the incidence of preterm delivery was 20.9%. Nifedipine was twice more effective than isoxpurine hydrochloride as a tocolytic agent as a tocolytic agent (P value 0.006) while side effects were comparable (P value 0.133). In earlydiagnosed preterm labor, nifedipine had higher efficacy than isoxpurine (P value 6.45 9 10 -6 ) and also higher efficacy than its own in late diagnosed preterm labor (P value 2.08 9 10 -5 ). Conclusions There is a high incidence of preterm labor in India. Nifedipine is a better tocolytic drug than isoxpurine hydrochloride, especially when started with the earliest signs of preterm labor.

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“…564 The review of inhibition of threatened preterm labour with calcium channel blockers 565 included 12 RCTs. [566][567][568][569][570][571][572][573][574][575][576][577] Updating the searches retrieved a further five RCTs. [578][579][580][581][582] Further details of the review can be found in Appendix 6, Table 133.…”

Section: Calcium Channel Blockersmentioning

confidence: 99%

“…[566][567][568][569][571][572][573][574][575][578][579][580] Twelve studies excluded women with multiple gestations. [566][567][568][569]571,[574][575][576][577][578]580,581 Studies that included women with multiple gestations are denoted with an asterisk in the forest plots. 570,572,573,579,582 Data were available on the following outcomes: birth within 48 hours of intervention, birth within 7 days of intervention, spontaneous preterm birth before 37 weeks' gestation, spontaneous preterm birth before 34 weeks' gestation, perinatal mortality and admission to neonatal intensive care.…”

Section: Calcium Channel Blockersmentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

2010

Clinical Governance: An International Journal

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A prospective, randomized trial of nifedipine vs. ritodrine in threatened preterm labor

Cited by 69 publications

References 20 publications

Comparison of effects of nifedipine and ritodrine on maternal and fetal blood flow patterns in preterm labor

Comparison of effects of nifedipine and ritodrine on maternal and fetal blood flow patterns in preterm labor

Comparative Study of Nifedipine and Isoxpurine as Tocolytics for Preterm Labor

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

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