A prospective randomized trial of intravenous ketorolac vs. acetaminophen administered with opioid patient-controlled analgesia in gynecologic surgery

Rakowski, J.A.; Holloway, Robert W.; Ahmad, Sarfraz; Jeppson, Corinne N.; James, Jeffrey A.; Ghurani, G.B.; Bigsby, Glenn E.; Kendrick, James E.

doi:10.1016/j.ygyno.2019.09.019

Cited by 10 publications

(5 citation statements)

References 13 publications

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“…The necessary intraoperative insulation measures can reduce the stress damage caused by hypothermia to the organism. In terms of postoperative analgesia, the combination of pain pumps and opioid analgesics has been shown to be effective in relieving pain stress caused by surgical trauma and creating conditions for the patient to get out of bed early ( 28 ). Early postoperative trans oral feeding helps to promote intestinal peristalsis, maintain intestinal mucosal function, shorten postoperative anal venting time, and to a certain extent reduce the amount of postoperative fluids, which in turn helps to prevent hypoxemia and pulmonary edema and promote recovery of gastrointestinal function.…”

Section: Discussionmentioning

confidence: 99%

Study on the Application Effect of Fast Track Surgery Care Combined With Continuous Care After Discharge in Patients With Laparoscopic Cholecystectomy

Lin

Chen

2022

Front. Surg.

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PurposeTo explore the application effect of fast track surgery (FTS) care combined with continuous care after discharge in patients with laparoscopic cholecystectomy (LC).MethodsTwo hundred patients treated with LC in our hospital from May 2020 to September 2021 were selected and divided into the routine group receiving routine care (n = 100) and the combined group receiving FTS care combined with continuous care after discharge (n = 100) according to their care methods. We observed the care effect, surgical stress levels [epinephrine, cortisol, Hamilton anxiety scale (HAMA)], postoperative recovery (time to first exhaust, time to first meal, time to first getting out of bed, time to hospitalization), complications, SF-36 scores after discharge, and care satisfaction in both groups.ResultsThe total efficiency of care in the combined group was better than that in the routine group (P < 0.05). At 1 d after surgery, the levels of epinephrine and cortisol in both groups were significantly higher than those at 1 h before surgery, and the HAMA scores were significantly lower than those at 1 h before surgery, and the combined group was lower than the routine group (P < 0.05). The time to first exhaustion, time to first meal, time to first getting out of bed, and time to hospitalization were shorter in the combined group than in the routine group (P < 0.05). The overall complication rate in the combined group was lower than that in the routine group (P < 0.05). The each item of SF-36 scores after discharge were higher in the combined group than in the routine group (P < 0.05). The total satisfaction with care was higher in the combined group than in the routine group (P < 0.05).ConclusionThe implementation of FTS care combined with continuous care after discharge in LC patients is ideal, which can significantly reduce the level of surgical stress, accelerate the recovery process, and reduce the occurrence of complications, and improve the postoperative quality of life of patients significantly, and with high satisfaction, which is worthy of application.

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Section: Discussionmentioning

confidence: 99%

Study on the Application Effect of Fast Track Surgery Care Combined With Continuous Care After Discharge in Patients With Laparoscopic Cholecystectomy

Lin

Chen

2022

Front. Surg.

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“…Common therapeutic measures include the administration of non-narcotic and narcotic analgesics (opioids). The types of drugs used are [195]: Most drugs reduce blood pressure and respiratory depression, bradycardia, and confusion [196,197]. Scientific methods of acute postoperative pain relief introduce the use of both narcotic and non-narcotic drugs along with the use of nerve blocks as the method of choice for complete postoperative pain relief.…”

Section: Mechanisms Of Opioid Activitymentioning

confidence: 99%

Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action

Akbarian

Ali

Eghbalpour

et al. 2022

IJMS

221

126

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Bioactive peptides are a group of biological molecules that are normally buried in the structure of parent proteins and become active after the cleavage of the proteins. Another group of peptides is actively produced and found in many microorganisms and the body of organisms. Today, many groups of bioactive peptides have been marketed chemically or recombinantly. This article reviews the various production methods and sources of these important/ubiquitous and useful biomolecules. Their applications, such as antimicrobial, antihypertensive, antioxidant activities, blood-lipid-lowering effect, opioid role, antiobesity, ability to bind minerals, antidiabetic, and antiaging effects, will be explored. The types of pathways proposed for bioactive applications will be in the next part of the article, and at the end, the future perspectives of bioactive peptides will be reviewed. Reading this article is recommended for researchers interested in various fields of physiology, microbiology, biochemistry, and nanotechnology and food industry professionals.

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“…Multiple trials have explored methods to alleviate POI, such as competent pain control, gum chewing, preoperative mobilization, coffee consumption, epidural anesthesia, and the use of motility agents such as neostigmine and alvimopan. [4][5][6][7][8][9][10][11] Nevertheless, POI remains a challenging clinical problem that hampers the prompt recovery of patients after abdominal surgery.…”

Section: Introductionmentioning

confidence: 99%

Effect of abdominal hot pack application on gastrointestinal motility recovery after comprehensive gynecologic staging surgery

Güngördük,

Selimoğlu,

Gülseren

et al. 2023

Intl J Gynecology & Obste

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ObjectiveTo evaluate whether abdominal hot water pack application improves gastrointestinal motility following gynecological oncology surgery.MethodsThe study was registered at ClinicalTrials.gov (NCT04833699). (https://clinicaltrials.gov/ct2/show/NCT04833699?cond=NCT04833699&draw=2&rank=1). In this randomized controlled trial, participants were randomly assigned (1:1) to the hot water pack group (standardized enhanced recovery protocols plus rubber water bag with a fluffy cover filled with boiled tap water [80°C] and placed on the abdomen at 3, 6, 9, and 12 h postoperatively for 30 min each time) or the control group (standardized enhanced recovery protocols). A subumbilical or supraumbilical vertical midline incision was made to perform staging surgery procedures, including hysterectomy, salpingo‐oophorectomy with retroperitoneal lymphadenectomy. The primary outcome was the time to first passage of flatus from the end of the staging procedure.ResultsIn total, 121 women were randomized to the control (n = 62) or hot water pack (n = 59) group. The use of an abdominal hot water pack significantly reduced the mean time to passing first flatus (25.2 ± 3.6 vs. 30.6 ± 3.9 h; hazard ratio [HR] = 4.4; 95% confidence interval [CI]: 2.8–7.1; P < 0.0001), mean time to first bowel movements (28.4 ± 4.0 vs. 34.4 ± 4.5 h; HR = 4.9; 95% CI: 3.0–7.9; P < 0.0001), mean time to first defecation (33.4 ± 4.9 vs. 41.0 ± 7.6 h; HR = 4.3; 95% CI: 2.1–6.8; P < 0.0001), and mean time to tolerating solid diet (2.1 ± 0.6 vs. 2.8 ± 1.0 days; HR = 4.4; 95% CI: 2.2–8.7; P < 0.0001) compared to the control group. The postoperative ileus incidence was significantly lower in the hot water pack group (3.4%) than the control group (16.1%) (P = 0.01).ConclusionAbdominal hot water pack application improved gastrointestinal function recovery in women following surgical staging procedures for gynecological malignancy.

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A prospective randomized trial of intravenous ketorolac vs. acetaminophen administered with opioid patient-controlled analgesia in gynecologic surgery

Cited by 10 publications

References 13 publications

Study on the Application Effect of Fast Track Surgery Care Combined With Continuous Care After Discharge in Patients With Laparoscopic Cholecystectomy

Study on the Application Effect of Fast Track Surgery Care Combined With Continuous Care After Discharge in Patients With Laparoscopic Cholecystectomy

Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action

Effect of abdominal hot pack application on gastrointestinal motility recovery after comprehensive gynecologic staging surgery

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