A prospective randomized study to assess the efficacy of a surgical sealant to treat air leaks in lung surgery☆☆☆

D’Andrilli, Antonio; Andreetti, Claudio; Ibrahim, Mohsen; Ciccone, Anna Maria; Venuta, Federico; Mansmann, Ulrich; Rendina, Erino Angelo

doi:10.1016/j.ejcts.2009.01.027

Cited by 65 publications

(58 citation statements)

References 15 publications

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“…A recent study examined the use of same biodegradable spray polymer for the closure of IOAAL after minimally invasive pulmonary resection was not a randomised controlled trial (13). Other randomised controlled trials analysing lung sealant efficacy were almost exclusively in patients undergoing thoracotomy (14)(15)(16). Cost analysis showed a significant reduction of hospitalisation costs, although no significant differences in postoperative complications were showed.…”

Section: Discussionmentioning

confidence: 99%

Cost-effectiveness analysis of sealant impact in management of moderate intraoperative alveolar air leaks during video-assisted thoracoscopic surgery lobectomy: a multicentre randomised controlled trial

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Cost-effectiveness analysis of sealant impact in management of moderate intraoperative alveolar air leaks during video-assisted thoracoscopic surgery lobectomy: a multicentre randomised controlled trial

et al. 2017

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“…CoSeal ® is used in thoracic surgery in the treatment of air leaks. Clinical results for this indication are contradictory in the duration of air leaks and hospitalization [7,8]. CoSeal swells in the presence of moisture and expands to quadruple in volume within 24 hours after application and additional swelling may occur as the gel is resorbed.…”

Section: Introductionmentioning

confidence: 94%

Adhesion of surgical sealants used in cardiothoracic and vascular surgery

Perrin

Braccini

Bidan

et al. 2016

International Journal of Adhesion and Adhesives

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International audienceSurgical sealants are widely used in cardiothoracic and vascular surgery essentially for hemostasis and sealing. Their adhesive properties have mainly been studied by clinical experiments. The objective of this study is to measure adhesion of the three main types of surgical sealant used in cardiothoracic and vascular surgery under normalized realistic conditions. The bulge-and-blister test was used to quantify adhesive performances of three types of surgical adhesives: cyanoacrylates, polyethylene glycol (PEG), and aldehydes. Samples were composed of two circular layers of equine pericardium glued by the surgical sealant studied. Comparative adhesion testing was carried out in eight samples bonded with a Dermabond® (cyanoacrylate), five samples with Bioglue® (aldehyde), four samples with Coseal® (PEG), and thirteen samples bonded with an industrial cyanoacrylate. Scanning electron microscope (SEM) observations of cross-sections of samples glued by Dermabond® and environmental scanning electron microscopy (ESEM) images of samples composed of equine pericardium glued by Bioglue® were also performed. The average value of the adhesion energy is 2.3+/-1.5 J.m-2 for samples glued with Dermabond®, 6.04+/-1.61 J.m-2 with Bioglue®, 2.37+/-1.25 J m-2 with Coseal®, 3.74+/-1.33 J m-2 with the industrial cyanoacrylate glue in surgical conditions. SEM observations of cross-sections of samples glued by Dermabond® showed a failure at the interface between the glue and the pericardial layer. ESEM observations have revealed a majority of regions where the glue is not linked to the pericardium. Adhesive performance measurements and microscopy observations in surgical conditions show that surgical sealants adhesion is weak and explain their poor efficacy in clinical practice. To improve adhesion in the surgical field, we need to focus on achieving a better cohesion between the adhesive and the substrate by modifying conditions adhesive bonding and consequently tend toward cohesive failure

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“…All of these techniques are possible with VATS, but not necessarily easy to perform given the small ports. Surgical sealants were a potentially easy-to-use solution and previous studies have shown that sealants may help reduce air leaks (Tansley et al, 2006;D'Andrilli et al, 2009). However, for a long time there was no effective means of delivery into the chest via the small VATS wounds.…”

Section: Current Challenges Emerging Solutionsmentioning

confidence: 99%

The Evolution of VATS Lobectomy

Sihoe¹

2012

Topics in Thoracic Surgery

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A prospective randomized study to assess the efficacy of a surgical sealant to treat air leaks in lung surgery☆☆☆

Abstract: The application of Coseal sealant proved safe and effective in reducing air leaks occurring after lung resection and in shortening the duration of postoperative air leak with a trend towards a shorter postoperative hospital stay.

Cited by 65 publications

References 15 publications

Cost-effectiveness analysis of sealant impact in management of moderate intraoperative alveolar air leaks during video-assisted thoracoscopic surgery lobectomy: a multicentre randomised controlled trial

Cost-effectiveness analysis of sealant impact in management of moderate intraoperative alveolar air leaks during video-assisted thoracoscopic surgery lobectomy: a multicentre randomised controlled trial

Adhesion of surgical sealants used in cardiothoracic and vascular surgery

The Evolution of VATS Lobectomy

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