A Prospective Randomized Study: The Usefulness and Efficacy of Negative Pressure Wound Therapy with Lipidocolloid Polyester Mesh Compared to Traditional Negative Pressure Wound Therapy for Treatment of Pressure Ulcers

Abstract

To improve healing of pressure ulcer wounds, it is important to optimize the conditions of the area surrounding the wound. Negative pressure wound therapy (NPWT) promotes wound healing, however, the removal of NPWT can cause pain or focal bleeding, delaying wound healing or causing infection. In this study, we reviewed the efficacy of the lipidocolloid non-adherent dressing (Urgotul®) as a wound contact layer. A total of 38 patients from the same facility who applied NPWT from April 2016 to October 2019 were included and divided into two groups; NPWT with the lipidocolloid non-adherent dressing (group 1, experimental group, 19 patients) and NPWT only (group 2, control group, 19 patients). The condition of the wound was examined prior to NPWT application, at one week, and again at three weeks after application. No significant differences were found between groups for general characteristics, bacterial culture or photo analysis. However, when comparing groups based on the time of examination, there was a significant reduction of the wound size in group 1 (p = 0.001) but not in group 2 (p = 0.082). Therefore, the current study finds that using the lipidocolloid non-adherent dressing as a wound contact layer in NPWT stimulates healing by shrinking the size of the pressure ulcer wound.

Effectiveness of negative pressure wound therapy on chronic wound healing: A systematic review and meta-analysis

“…In terms of the age of the respondents in the 15 articles on NPWT in chronic wound patients, nine involved respondents aged 13-35 years (Alghadir et al, 2018 ; Benrashid et al, 2020 ; Bertges et al, 2021 ; Costa et al, 2020 ; Iqbal et al, 2016 ; Kamamoto et al, 2017 ; Kirsner et al, 2019 ; Lavery et al, 2020 ; Seidel et al, 2020 ; Zhou et al, 2016 ), while one involved those aged between 18-80 years. Meanwhile, the remaining five articles employed those aged >60 years old, namely 60 to 80 years old (Baek et al, 2020 ; Chiang et al, 2017 ; De Rooij et al, 2021 ; Deborre et al, 2021 ; Maduba et al, 2020 ).…”

“…The ninth article discussed traditional methods and NPWT against chronic wounds (Kirsner et al, 2019 ), while the tenth, eleventh, and twelfth aimed at reducing patient hospitalizations and the development of the wound healing process, including infection, surface area, size, and differences in treatment costs (Kamamoto et al, 2017 ; Lavery et al, 2020 ). Moreover, the thirteenth article examined the healing of pressure ulcers against increased granulation and control of infection on the wound surface (Baek et al, 2020 ). Finally, three articles discussed the effectiveness of NPWT in increasing wound size, controlling infection, speeding up closure, and reducing hospitalization (Bertges et al, 2021 ; Iqbal et al, 2016 ; Zhou et al, 2016 ).…”

“…The tenth article used a similar design with 38 samples categorized into two groups: the intervention ( n = 19) and the control ( n = 19) with pressure ulcer stage 3-4 and wound aged nine months. The measuring instrument was VISITRAK for the wound area (Baek et al, 2020 ). Moreover, the eleventh article was an RCT study on a total sample of 150 with chronic size 5-10 cm, ABI values of 0.5 mmHg, and TBI >30 mmHg.…”

Efficacy of the combination of Chinese herbal medicine and negative pressure wound therapy in the treatment of patients with diabetic foot ulcer: A meta‐analysis

“…Currently, the application of NPWT is expanding and its advantages are being increasingly recognised. Some scholars have even claimed that NPWT has brought about a revolutionary change in the treatment of extremity wounds 8,9 . Although NPWT has opened a new avenue for the treatment of difficult‐to‐heal wounds in patients with diabetic feet, there is still room for progress in simple NPWT.…”

“…Some scholars have even claimed that NPWT has brought about a revolutionary change in the treatment of extremity wounds. 8 , 9 Although NPWT has opened a new avenue for the treatment of difficult‐to‐heal wounds in patients with diabetic feet, there is still room for progress in simple NPWT. In recent years, relevant studies have explored the positive effects of combining other auxiliary methods with NPWT for treating patients with diabetic feet, and combination with traditional Chinese medicine (TCM) has been suggested as a novel approach.…”