Abstract:Heparin-bonded grafts demonstrated a trend to improved patency, but the difference was not statistically significant. Heparin-bonded grafts had a significantly lower early thrombosis rate that was sustained only for the first 5 months of follow-up.
“…Some examples to enhance hemocompatibility include plasma surface modification, the grafting of oligo and poly(ethylene glycol)s (OEG, PEG), zwitterionic structures, heparin modification, the fabrication of PEGylated terapolymers, and the endothelialization of biomaterial surfaces. 1,3,[7][8][9][10][11][12][13][14][15][16][17][18][19] . Among the many techniques proposed to enhance hemocompatibility, much success has been found through the exploration of hyaluronan (HA) enhanced surfaces which have been shown to placate the hemostatic response.…”
“…Some examples to enhance hemocompatibility include plasma surface modification, the grafting of oligo and poly(ethylene glycol)s (OEG, PEG), zwitterionic structures, heparin modification, the fabrication of PEGylated terapolymers, and the endothelialization of biomaterial surfaces. 1,3,[7][8][9][10][11][12][13][14][15][16][17][18][19] . Among the many techniques proposed to enhance hemocompatibility, much success has been found through the exploration of hyaluronan (HA) enhanced surfaces which have been shown to placate the hemostatic response.…”
“…First, it is a nonrandomized study and represents the description of a single center/surgeon experience which limits its external generalizability to surgeons less experienced in AVG primary operations and revisions. This may have had a positive impact on our results in contrast to multicenter studies producing overall lower patency rates . Second, the sample size of the SG‐group was rather small for important clinical implications for the unbiased presentation of this new vascular access option.…”
Section: Discussionmentioning
confidence: 92%
“…This may have had a positive impact on our results in contrast to multicenter studies producing overall lower patency rates. 35 Second, the sample size of the SG-group was rather small for important clinical implications for the unbiased presentation of this new vascular access option. It may be possible that larger SG cohort could bring this close to significance superior patency of SGs to statistically significant level.…”
There was a trend toward better primary and secondary patency rates for the SGs especially in the long-term. This is a valuable option in selected patients that access surgeons and nephrologists should be aware of.
“…They did note that the HB-PTFE grafts had significantly less thrombosis in first 5 months after implantation than the S-PTFE graft. 15 The cost of HB-PTFE grafts has been reported to be 18% more than that of S-PTFE grafts. 6 One study estimated that the difference was $650 for equivalent graft lengths, and in their hands, if no heparin grafts were used over period of their study, the total institutional cost savings would translate to $39,404 in 2013 dollars (w$938 per month).…”
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