A Prospective Randomized Study of Inpatient IV Antibiotics for Community-Acquired Pneumonia

Community-acquired pneumonia in Ugandan adults: short-term parenteral ampicillin therapy for bacterial pneumonia.

“…28 Recent studies indicated the successful treatment by shortterm parenteral ␤-lactam antibiotics prior to an oral switch for hospitalized patient with uncomplicated CAP. 10,11 In India, investigators reported that all patients with CAP responded to one week of parenteral penicillin followed by oral antibiotics, with a total therapy duration of 10 days. 10 No study, however, has evaluated the usefulness of short-term parenteral antibiotic therapy for CAP in HIV-infected individuals, especially in developing countries.…”

“…10 Moreover, Siegel and colleagues similarly demonstrated the cost-effectiveness of short-term parenteral therapy with cephalosporins for CAP in the US. 11 On the other hand, two recent studies in Africa have demonstrated the etiologic diagnosis and outcome of patients with community-acquired pneumonia (CAP). These studies reported relatively low frequencies of HIV infection among these patients (8% in Ethiopia and 26% in Cameroon), but did not focus on the effectiveness of antibiotic treatment.…”

Diagnosis and Treatment of Community‐Acquired Pneumonia

“…31,32 This pattern of resistance increases the cost of treatment because of prolonged hospitalization, relapses, and the use of more expensive antibacterial agents. [33][34][35][36][37] …”

“…[33][34][35][36][37] Using agents with longer half-lives allows for once-daily administration, which in turn leads to improved compliance and outcomes and decreased costs. [33][34][35][36][37] In addition, transitioning patients to oral therapy as soon as they are clinically stable can significantly reduce the length of hospitalization-the major contributing factor to health care costs. [33][34][35][36][37] American Family Physician 449…”

“…[33][34][35][36][37] In addition, transitioning patients to oral therapy as soon as they are clinically stable can significantly reduce the length of hospitalization-the major contributing factor to health care costs. [33][34][35][36][37] American Family Physician 449…”