A prospective randomized study comparing two commercially available types of human embryo culture media: G1-PLUSTM/G2-PLUSTM sequential medium (Vitrolife) and the GL BLASTTM sole medium (Ingamed)

Ceschin, Ianae I; Ribas, Mariana H; Ceschin, Artemis Marti; Nishikawa, Lucileine; Rocha, C.C.; Pic‐Taylor, Aline; Baroneza, José Eduardo

doi:10.5935/1518-0557.20160006

Cited by 2 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In three RCTs, no difference in biochemical pregnancy rate was found comparing G5 to HTF, GV Blast Sole and Universal IVF Medium (Kleijkers et al, 2016;Ceschin et al, 2016;Hambiliki et al, 2011) (Table 7).…”

Section: Biochemical Pregnancy Ratementioning

confidence: 97%

Embryo Culture Media Influence on Live Birth Rate and Birthweight after IVF/ICSI: A Systematic Review Comparing Vitrolife G5 Media to Other Common Culture Media

Bick

Nielsen

Knudsen

2021

JBRA

View full text Add to dashboard Cite

Previous studies have indicated that culture media vary in efficiency and outcomes, such as live birth rate, birthweight and embryo quality. Does Vitrolife G5 series culture media result in higher live birth rates and birthweight compared to other common culture media? This study is a systematic review based on the PRISMA criteria. Relevant search terms, mesh terms (PubMed and Cochrane) and Emtree terms (Embase) were identified. We searched the literature using PubMed, Embase and Cochrane, on November 10, 2019. The inclusion criteria involved published articles in English comparing Vitrolife G5 to other common culture media. We included randomized controlled trials (RCTs) and cohort studies. The quality of the studies was assessed using the Cochrane Risk of Bias tool 2.0 and the Newcastle-Ottawa Scale. Primary outcomes were live birth rate and birthweight. Secondary outcomes were fertilization rate, implantation rate, biochemical pregnancy rate, clinical pregnancy rate, miscarriage rate, multiple pregnancies and congenital malformations. Of 187 articles screened, 11 studies fulfilled the inclusion criteria: Five RCTs and six retrospective cohort studies. Only one study reported live birth rate, showing a non-significantly higher live birth rate for Vitrolife G5 media. Birthweight had equivocal results with three of six studies, showing significantly lower (2)/higher (1) birthweights, whereas the others were non-significant. Overall, there were no significant differences concerning secondary outcomes. The results are equivocal, and we need more studies to evaluate culture media and their effect on short-and longterm health.

show abstract

Section: Biochemical Pregnancy Ratementioning

confidence: 97%