A Prospective Randomized Study Comparing Polidocanol Foam Sclerotherapy with Surgical Treatment of Patients with Primary Chronic Venous Insufficiency and Ulcer

Campos, Walter; Torres, Inez Ohashi; Silva, Erasmo Simão da; Casella, Ivan Benaduce; Puech-Leão, Pedro

doi:10.1016/j.avsg.2015.01.031

Cited by 38 publications

(23 citation statements)

References 22 publications

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“…26 Abolition of venous reflux performed by UGFS also promotes ulcer healing. 27,28 Deep venous reflux is the main risk factor for delayed healing, according to the present multivariate analysis. Ulcer size and duration, claimed to be other main determinants of healing time, 29 are also important negative prognostic factors in the present case series, together with PAOD.…”

Section: Discussionmentioning

confidence: 51%

Recalcitrant Venous Leg Ulcers May Heal by Outpatient Treatment of Venous Disease Even in the Presence of Concomitant Arterial Occlusive Disease

Mosti¹,

Cavezzi

Massimetti

et al. 2016

European Journal of Vascular and Endovascular Surgery

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Section: Discussionmentioning

confidence: 51%

Recalcitrant Venous Leg Ulcers May Heal by Outpatient Treatment of Venous Disease Even in the Presence of Concomitant Arterial Occlusive Disease

Mosti¹,

Cavezzi

Massimetti

et al. 2016

European Journal of Vascular and Endovascular Surgery

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“…There were no severe complications or differences in relation to surgical group. Ulcer healing rate, clinical improvement and of QL were similar 88,90 . Silva 91 identified healing of 84.2% of ulcers.…”

Section: Foam Sclerotherapy Resultsmentioning

confidence: 67%

“…Several authors that study healing of varicose ulcers following UFS report healing rates higher than those of ESCHAR study, however, there is a predominance of non-comparative studies. O'Hare 86 reported 91.2% rate of healing in 24 weeks, Kulkarni 87 71.1% in 24 weeks, Campos 88 91.3% after one year and Cabrera 89 83% in six months. Campos 90 , in 2014, randomized 49 patients with ulcer and GSV reflux for surgery or UFS.…”

Section: Foam Sclerotherapy Resultsmentioning

confidence: 98%

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Ultrasound-guided foam sclerotherapy for severe chronic venous insufficiency

de-Abreu

Júnior

de-Abreu

et al. 2017

Rev. Col. Bras. Cir.

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Chronic venous insufficiency is characterized by cutaneous alterations caused by venous hypertension; in severe forms, it progresses to lower limb ulcers. Lower limb varicose veins are the main cause of chronic venous insufficiency, and the classic treatment includes surgery and compressive therapy. Minimally invasive alternative treatments for varicose veins include new techniques such as venous thermal ablation using laser or radiofrequency. The use of different methods depends on clinical and anatomical factors. Ultrasound-guided foam sclerotherapy is the venous injection of sclerosing foam controlled by Doppler ultrasound. Sclerotherapy is very useful to treat varicose veins, and probably, is cheaper than other methods. However, until the present, it is the less studied method.

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“…After full text evaluation, 62 studies discussing sclerotherapy management of varicose veins were included involving 3689 patients (CDFS 789 and FS 2900). 11,16,19,20,28–84 Of these, there were 48 studies for UGFS and 15 studies for CDFS. There was only one randomized controlled trial directly comparing these two alternatives.…”

Section: Resultsmentioning

confidence: 99%

Catheter-directed foam sclerotherapy, an alternative to ultrasound-guided foam sclerotherapy for varicose vein treatment: A systematic review and meta-analysis

et al. 2020

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Purpose Catheter-directed foam sclerotherapy is a new addition to the treatment modalities available for varicose veins. As a modification of ultrasound-guided foam sclerotherapy, catheter-directed foam sclerotherapy has been purported to offer higher complete ablation rates and an improved safety profile. The aim of this study is to appraise the current literature on the outcomes of catheter-directed foam sclerotherapy compared to ultrasound-guided foam sclerotherapy in chronic venous insufficiency. Methods The review of the literature was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data from studies that reported the outcomes of catheter-directed foam sclerotherapy and ultrasound-guided foam sclerotherapy were extracted, to determine the pooled proportion of complete ablation rates, using a random effect meta-analysis model. Results A total of 62 studies, involving 3689 patients, were included in the systematic review. Higher rates of complete ablation were reported in catheter-directed foam sclerotherapy compared to ultrasound-guided foam sclerotherapy during the short- and medium-term follow-ups (Relative Risk = 1.06, Relative Risk = 1.15, Relative Risk = 1.19, p < 0.05). Fewer major and minor complications were also reported in patients who underwent catheter-directed foam sclerotherapy (Relative Risk = 0.23, Relative Risk= 0.43–0.76, p < 0.05). Conclusion Catheter-directed foam sclerotherapy has been demonstrated to have many advantages over ultrasound-guided foam sclerotherapy, offering superior complete ablation rates in the short-, medium- and long-term follow-ups. It also has a better safety profile, conferring a lower risk of major and minor complications. The conclusions should however be viewed in the context of significant limitations imposed by limited study data.

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A Prospective Randomized Study Comparing Polidocanol Foam Sclerotherapy with Surgical Treatment of Patients with Primary Chronic Venous Insufficiency and Ulcer

Abstract: Surgical treatment and foam sclerotherapy achieved high rates of ulcer healing, without a statistically significant difference. Both treatments led to significant improvements in VCSS, VDS, AVVQ scores, demonstrating improvements in clinical outcomes and quality of life.

Cited by 38 publications

References 22 publications

Recalcitrant Venous Leg Ulcers May Heal by Outpatient Treatment of Venous Disease Even in the Presence of Concomitant Arterial Occlusive Disease

Recalcitrant Venous Leg Ulcers May Heal by Outpatient Treatment of Venous Disease Even in the Presence of Concomitant Arterial Occlusive Disease

Ultrasound-guided foam sclerotherapy for severe chronic venous insufficiency

Catheter-directed foam sclerotherapy, an alternative to ultrasound-guided foam sclerotherapy for varicose vein treatment: A systematic review and meta-analysis

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