A prospective, randomized, double-blind, placebo-controlled trial of multimodal intraoperative analgesia for laparoscopic excision of endometriosis

Pain Testing in Endometriosis for the Clinician

“…There have been several blinded controlled trials of the excision versus sham excision of endometriosis for the management of pain [19][20][21][22]. The results have differed; in several, there was a reduction in pain; in another that was extended out 14 years post-randomization, there was no difference between the sham excision and excision.…”

Pain Management Strategies for Urogynecologic Surgery

“…8 An interim analysis prompted early termination of the study after 66 patients were enrolled because of the finding of a significantly decreased opioid requirement noted in the analgesia group compared with the placebo group (19.0 mg vs 34.5 mg; difference, j14 mg; 95% confidence interval, j26.0 to 2.0 mg). The analgesia consisted of diclofenac 100 mg suppository per rectum and 0.75% ropivacaine to portal sites subperitoneally under excision sites and topically to each subdiaphragmatic area.…”

Extended periprostatic nerve distributions on the prostate surface confirmed using diffusion tensor imaging

“…Various publications have addressed the distribution of prostatic extracapsular nerves . In addition to studies using cadavers , fresh specimens from non‐nerve‐sparing RPs have been used as a negative matrix representing the neural anatomy of the patient's prostatic fossa . Initial morphometric studies have histologically determined neural tissue using haematoxylin and eosin , and more recent studies have used neuronal markers such as protein gene product (PGP) 9.5 staining .…”