A prospective, randomized, double blind, comparative study of intramuscular nalbuphine hydrochloride, butorphanol tartrate and pentazocine lactate for post-operative pain relief following abdominal hysterectomy

Praveen, Prav; Konda, Vijaya Chandra Reddy; K, Lohit

doi:10.18203/2319-2003.ijbcp20164049

Cited by 1 publication

(2 citation statements)

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“…In a recent randomized, double-blind study comparing IM butorphanol vs pentazocine for postoperative pain relief, butorphanol was reported to be more effective and safer analgesia compared to pentazocine for postoperative pain management in gynecologic lower abdominal surgery. 14 Here, both nalbuphine and butorphanol administered intramuscularly provided better analgesia, rapid onset, and longer duration of analgesia compared to pentazocine. Also, the incidence of nausea and vomiting was also low as against pentazocine.…”

Section: Discussionmentioning

confidence: 82%

“…Also, the incidence of nausea and vomiting was also low as against pentazocine. 14 Butorphanol is reported to be more effective analgesia with lesser side effects as compared to fentanyl in a comparative study in lower abdominal surgeries. 15 Butorphanol is also used as EP adjuvants in abdominal hysterectomy under intrathecal levobupivacaine anesthesia.…”

Section: Discussionmentioning

confidence: 98%

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Comparative Evaluation of Efficacy and Safety of Intramuscular Butorphanol vs Epidural Butorphanol as Postoperative Analgesia in Patients Undergoing Lower Abdominal and Lower Limb Surgeries: A Randomized-controlled Study

Doshi¹,

Vyas²,

Kurian³

et al. 2019

Journal of Research &Amp; Innovation in Anesthesia

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Context: Intramuscular (IM) butorphanol can be a convenient postoperative analgesia compared to epidural (EP) route. Aims: Compare the efficacy and safety of IM vs EP butorphanol (1 mg/2 mg) as postoperative analgesia. Settings and design: A randomized-controlled study. Materials and methods: This study was conducted on 120 adult patients of either sex in the age group of 20-60 years, undergoing lower abdominal or lower limb surgeries (American Society of Anesthesiologists [ASA] class-I/II). Patients were randomized to butorphanol intramuscularly (IM group) or EP injection (EP group). Each group had two equal subgroups where patients received either 1 mg or 2 mg by the respective route. The primary outcomes were onset of analgesia, peak time of analgesia, and duration of analgesia. Pain was assessed on a 0-10 visual analog scale (VAS), and vital parameters were assessed at baseline and after 10, 20, 30, 60, 90, 120, and 180 minutes. Clinical safety was assessed by the adverse events. Results: The duration of analgesia provided by both the routes was comparable (293.0 minutes IM and 270.25 minutes EP). However, duration of analgesia was longer (p, 0.043) with 2 mg compared to 1 mg. Similarly, the onset of analgesia, pain scores, and peak time of analgesia were similar (p > 0.05) in the two groups. No differences in the hemodynamic parameters and respiratory rate were observed in the two groups. Higher incidence of all the side effects (sedation, somnolence, pruritus) was observed with IM administration. All side effects were clinically insignificant. Conclusion:Intramuscular butorphanol is as effective as an EP for the management of immediate postoperative pain. Keymessages: Intramuscular analgesics could be more convenient and safer compared to EP administration. Butorphanol administered by the IM route is as effective and safe compared to EP administration.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 98%