A prospective randomized controlled trial to assess the efficacy and safety of prophylactic central compartment lymph node dissection in papillary thyroid carcinoma

Ahn, Ji Hyun; Kwak, JungHak; Yoon, Sang Gab; Yi, Jin Wook; Yu, Hyeong Won; Kwon, Hyungju; Kim, Su jin; Lee, Kyu Eun

doi:10.1016/j.surg.2021.03.071

Cited by 39 publications

(34 citation statements)

References 26 publications

(43 reference statements)

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“…Then, we read the full‐texts of the remaining seven citations, and excluded two citations with reasons 6,7 . Finally, five RCTs were included in this meta‐analysis 2,3,13–15 …”

Section: Resultsmentioning

confidence: 99%

“…The eligible 5 RCTs comprised a total of 795 patients; 410 and 385 patients were assigned to the TT plus pCND (experimental) and TT alone (control) group, respectively. The RCTs were conducted in 2015, 13,14 2020, 2,3 and 2021 15 . The RCTs originated in the Republic of Korea, 13,15 Italy, 14 Egypt, 2 and United States of America 3 .…”

Section: Resultsmentioning

confidence: 99%

“…The RCTs were conducted in 2015, 13,14 2020, 2,3 and 2021 15 . The RCTs originated in the Republic of Korea, 13,15 Italy, 14 Egypt, 2 and United States of America 3 . The mean age of patients ranged from 42.24 to 53.6 years and the vast majority of included patients were females ( n = 552, 69.4%).…”

Section: Resultsmentioning

confidence: 99%

“…6,7 Finally, five RCTs were included in this meta-analysis. 2,3,[13][14][15] Baseline Characteristics of the Included Studies…”

Section: Literature Searchmentioning

confidence: 99%

“…To date, few prospective randomized controlled trials (RCT) have attempted to delineate the clinical benefit of pCND in addition to TT, the standard treatment, among cN0 PTC patients. 2,3,[13][14][15] The results, nevertheless, have been inconsistent and limited by small sample size. In addition, thus far, no meta-analysis has been accomplished to pool evidence specifically from RCTs.…”

Section: Introductionmentioning

confidence: 99%

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Prophylactic Central Neck Dissection for Clinically Node‐Negative Papillary Thyroid Carcinoma

Alsubaie

Alzahrani

et al. 2021

The Laryngoscope

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Objective: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) that scrutinized the oncological benefits and postsurgical complications of total thyroidectomy (TT) plus prophylactic central neck dissection (pCND) versus TT alone among clinically node-negative (cN0) papillary thyroid cancer (PTC) patients.Methods: We screened five databases from inception to September 4, 2021 and evaluated the risk of bias of the eligible studies. We pooled dichotomous outcomes using the risk ratio (RR) with 95% confidence interval (CI).Results: Overall, we included 5 RCTs with low risk of bias comprising 795 patients (TT plus pCND = 410 and TT alone = 385). With regard to efficacy endpoint, the rate of structural loco-regional recurrence did not significantly differ between both groups (n = 4 RCTs, RR = 0.49, 95% CI [0.19, 1.27], P = .14). With regard to safety endpoints, the rates of hypoparathyroidism (n = 5 RCTs, RR = 1.48, 95% CI [0.73, 2.97], P = .27), recurrent laryngeal nerve injury (n = 5 RCTs, RR = 1.34, 95% CI [0.59, 3.03], P = .48), and bleeding (n = 3 RCTs, RR = 1.75, 95% CI [0.42, 7.26], P = .44) did not significantly differ between both groups.Conclusion: For cN0 PTC patients, there was no significant difference between TT plus pCND and TT alone with regard to the rate of structural loco-regional recurrence or frequency of postsurgical complications. Adaptation of pCND in cN0 PTC patients should be contemplated by taking into consideration the clinical oncological benefits and rate of postsurgical adverse events.

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“…Then, we read the full‐texts of the remaining seven citations, and excluded two citations with reasons 6,7 . Finally, five RCTs were included in this meta‐analysis 2,3,13–15 …”

Section: Resultsmentioning

confidence: 99%