A prospective randomized controlled trial of sclerotherapy vs ligation in the prophylactic treatment of high-risk esophageal varices

Svoboda, Petr; Kantorová, I; Ochmann, J; Kozumplík, L; Marsová, J

doi:10.1007/s004649901045

Cited by 64 publications

(45 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To improve these EVL results, we performed additional ethanol-EIS for varices that could not be eradicated by EVL alone. Nonetheless, variceal relapse also occurred in patients treated by this method, although the relapse rate and bleeding rate of esophageal varices compared to the reported results of EVL [26][27][28][29][30][31] were lower. The present study was performed to evaluate the effect of this treatment on portal hemodynamics, and especially on portal systemic shunts, and to determine how these hemodynamic changes are associated with variceal relapse.…”

Section: Discussioncontrasting

confidence: 61%

Study of hemodynamic changes in portal systemic shunts and their relation to variceal relapse after endoscopic variceal ligation combined with ethanol sclerotherapy

et al. 2006

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 61%

Study of hemodynamic changes in portal systemic shunts and their relation to variceal relapse after endoscopic variceal ligation combined with ethanol sclerotherapy

et al. 2006

View full text Add to dashboard Cite

show abstract

“…This finding is similar to results from several centers where rubber band ligation was compared with injection sclerotherapy and showed that far fewer sessions were required with banding to achieve variceal obliteration [17][18][19]. The fewer sessions of banding meant fewer risks of procedure related complications.…”

Section: Ale Alexander Femi Et Al: Endoscopic Variceal Band Ligationsupporting

confidence: 77%

Endoscopic Variceal Band Ligation: A Safe Way to Treat Oesophageal Varices

Femi¹

2016

CMR

View full text Add to dashboard Cite

Abstract:Bleeding from oesophageal varices is the most dreaded complication of chronic liver disease and is associated with high mortality. Endoscopic variceal ligation is one of the more recent effective treatment modalities. This study was aimed at evaluating our experience with endoscopic variceal ligation with a view to stressing the safety associated with the procedure. A prospective study of consecutive patients presenting to the Jos University Teaching Hospital and FOMAS hospital endoscopic units was conducted over a 6 year period. A total of 199 sessions of endoscopic sessions were carried out on 83 patients with different grades of varices. There were 68 males and 15 females (M:F = 4.5:1). The mean age of the study population was 48 +/-7.4 years with age range of 17 to 63 years. The number of sessions of banding required for variceal obliteration in this study varied from 43 (51.8%) who had 3 sessions of banding, 30 (36.1%) who had 2 sessions and 10 (12.0%) that had a single session of variceal band ligation. All patients were placed on Propanolol tablets. There were no recorded episodes of procedure related bleeding, significant re-bleeding, post-procedure retrosternal pain, stricture or ulceration in this study, attesting to the safety of endoscopic variceal ligation.

show abstract

“…been shown to be effective in decreasing bleeding, 4,[18][19][20][21] it is associated with side effects of its own, including postligation bleeding, pain from ulceration, dysphagia, and odynophagia. 10,11,[22][23][24] Few data exist regarding adjuvant therapy for EVL or sclerotherapy.…”

Section: Discussionmentioning

confidence: 99%

Pantoprazole reduces the size of postbanding ulcers after variceal band ligation: A randomized, controlled trial

et al. 2005

View full text Add to dashboard Cite

Elective esophageal variceal ligation (EVL) is performed to decrease the risk of variceal hemorrhage. Side effects of EVL include hemorrhage, chest pain, dysphagia, and odynophagia. Because gastric acid may exacerbate postbanding ulcers and delay healing, proton pump inhibition may decrease side effects associated with EVL. The aim of this study was to assess the efficacy of pantoprazole, a proton pump inhibitor, as an adjunct to elective EVL. We performed a double-blinded, randomized, placebo-controlled trial of pantoprazole after elective EVL. Subjects in the pantoprazole arm received 40 mg pantoprazole intravenously after EVL followed by 40 mg oral pantoprazole for 9 days. Control subjects received intravenous and oral placebo. Subjects underwent upper endoscopy 10 to 14 days after banding. Primary outcomes included the size and number of ulcers and the subjects' reports of dysphagia, chest pain, and heartburn. Forty-four subjects were randomized: 42 completed the protocol. At follow-up endoscopy, the mean number of ulcers was similar in the two groups. However, the ulcers in the pantoprazole group were on average half as large as in the placebo group (37 mm 2 vs. 82 mm 2 , P < .01). Chest pain, dysphagia, and heartburn scores were not significantly different. Four subjects, all in the placebo group, had adverse outcomes, including 3 who bled from postbanding ulcers and 1 with sepsis. In conclusion, subjects receiving pantoprazole after elective EVL had significantly smaller postbanding ulcers on follow-up endoscopy than subjects receiving placebo. However, the total ulcer number and patient symptoms were not different between the groups. (HEPATOLOGY 2005;41: 588-594.)

show abstract

A prospective randomized controlled trial of sclerotherapy vs ligation in the prophylactic treatment of high-risk esophageal varices

Cited by 64 publications

References 19 publications

Study of hemodynamic changes in portal systemic shunts and their relation to variceal relapse after endoscopic variceal ligation combined with ethanol sclerotherapy

Study of hemodynamic changes in portal systemic shunts and their relation to variceal relapse after endoscopic variceal ligation combined with ethanol sclerotherapy

Endoscopic Variceal Band Ligation: A Safe Way to Treat Oesophageal Varices

Pantoprazole reduces the size of postbanding ulcers after variceal band ligation: A randomized, controlled trial

Contact Info

Product

Resources

About