A prospective randomized controlled study comparing the pain relief in patients with osteoporotic vertebral compression fractures with the use of vertebroplasty or facet blocking

Wang, Biao; Guo, Hua; Li, Yuan; Huang, Dageng; Zhang, Haiping; Hao, Dingjun

doi:10.1007/s00586-016-4425-4

Cited by 50 publications

(41 citation statements)

References 26 publications

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“…These results are consistent with the adequately powered subgroup analyses from two previous blinded RCTs3 and another trial that compared vertebroplasty to facet injections in patients with acute compression fractures 6…”

Section: Implications For Practicesupporting

confidence: 86%

Conduct and reporting of a vertebroplasty trial warrants critical examination

et al. 2017

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Section: Implications For Practicesupporting

confidence: 86%

Conduct and reporting of a vertebroplasty trial warrants critical examination

et al. 2017

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“…After literature identified and examined, all the data in this network meta-analysis were extracted from 32 trials with 2,852 subjects [Grohs et al, 2005;Pflugmacher et al, 2005;De et al, 2007;Voormolen et al, 2007;Al-Qazaz and Elshafey, 2012;Zhou et al, 2008;Buchbinder et al, 2009;R€ ollinghoff et al, 2009;Schofer et al, 2009;Bae et al, 2010;Kasperk et al, 2010;Klazen et al, 2010;Kumar et al, 2010;Movrin et al, 2010;Rousing et al, 2010;Farrokhi et al, 2011;Folman and Shabat, 2011;Blasco et al, 2012;Kallmes, 2012;Movrin, 2012;Endres and Badura, 2012;Li et al, 2012;Omidikashani et al, 2012;Van Meirhaeghe et al, 2013;Chen et al, 2014;Du et al, 2014;Kroon et al, 2014;Liu et al, 2015;Wang et al, 2015Wang et al, , 2016Clark et al, 2016;Yang et al, 2016], compared the efficacy of PKP, PVP and CT in the aspects of VAS, ODI, KA, and the occurrence of fracture, the primary traits were listed in the Table I, indicating that the average age of the patients are above 60 and large portion of them are female. Among these 32 trials, VAS was the most frequent outcome, reported by all the trials except one.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Comparison of the Efficacy Between Two Micro‐Operative Therapies of Old Patients With Osteoporotic Vertebral Compression Fracture: A Network Meta‐Analysis

Zhang

Shi

Tang

et al. 2017

J of Cellular Biochemistry

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Osteoporotic vertebral compression fracture (OVCF) afflicts most aged people. Except for conservative therapy (CT), percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) are another two the common choices, but current evaluation of their efficacy is not performed. All the trial data were originated from electronic database including PubMed, Embase, and Cochrane Library. Four indicators with mean difference (MD) or odd ratio (OR) with their 95% credible interval (95% CrI) were analyzed to evaluate the efficacy, including the value of visual analog scale (VAS), Oswestry disability index (ODI), relieving kyphotic angle (KA), and rate of fracture. Besides, the results were demonstrated in the forest plots and slash tables. Furthermore, the surface under the cumulative ranking curve (SUCRA) was calculated. A total of 32 trials among 2,852 patients are included. Using network comparison, we found that PKP and PVP both have good performance as OVCF treatments. However, in different aspects, PKP seemed to be the best to eliminate pain with high value of SUCRA on ODI and VAS (0.624 and 0.588, respectively), and PVP had better performance in KA and decreasing incidence of fracture. The micro-operative therapy, both PKP and PVP, had better efficacy than CT in four aspects. And PKP was better in pain alleviating, according to VAS and ODI results, while PVP had the superiority in KA and reducing the incidence of fracture. J. Cell. Biochem. 118: 3205-3212, 2017. © 2017 Wiley Periodicals, Inc.

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“…After publications identified and checked, 27 RCTs [ 21 , 22 , 24 – 48 ] meet the inclusion criteria. The duplicate set of patients from multiple RCTs were regarded as one RCT named by the complete data and latest one or two, leaving a total of 18 RCTs [ 22 , 24 , 25 , 27 , 28 , 30 , 32 , 36 , 37 , 39 – 47 ] compared the efficacy of PVP, PKP, NB, and CT in the aspects of VAS. The primary traits were listed in Table 1 , indicating that a total of 1994 patients, the mean age of the patients above 60 and majority of female (551 males and 1443 females).…”

Section: Resultsmentioning

confidence: 99%

Network meta-analysis of percutaneous vertebroplasty, percutaneous kyphoplasty, nerve block, and conservative treatment for nonsurgery options of acute/subacute and chronic osteoporotic vertebral compression fractures (OVCFs) in short-term and long-term effects

et al. 2018

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Background:Osteoporotic vertebral compression fractures (OVCFs) commonly afflicts most aged people resulting back pain, substantial vertebral deformity, functional disability, decreased quality of life, and increased adjacent spinal fractures and mortality. Percutaneous vertebral augmentation (PVA) included percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP), nerve block (NB), and conservative treatment (CT) are used for the nonsurgery treatment strategy of OVCFs, however, current evaluation of their efficacy remains controversial.Methods and analysis:A systematic literature search was carried out in PubMed, EMBASE, Web of Knowledge, and the Cochrane Central Register of Controlled Trials up to October 31, 2017. Randomized controlled trials (RCTs) were compared PVP, PKP, NB, or CT for treating OVCFs. The risk of bias for each trial was rated according to the Cochrane Handbook. Mean differences (MDs) with 95% confidence intervals (CIs) were utilized to express VAS (visual analog scale) outcomes. The network meta-analysis (NMA) of the comparative efficacy measured by change of VAS on acute/subacute and chronic OVCFs was conducted for a short-term (<4 weeks) and long-term (≥6–12months) follow-up with the ADDIS software.Results:A total of 18 trials among 1994 patients were included in the NMA. The PVA (PVP and PKP) had better efficacy than CT. PKP was first option in alleviating pain in the case of the acute/subacute OVCFs for long term, and chronic OVCFs for short term and long term, while PVP had the most superiority in the case of the acute/subacute OVCFs for short term. NB ranks higher probability than PKP and PVP on acute/subacute OVCFs in short and long-term, respectively.Conclusions:The present results suggest that PVA (PVP/PKP) had better performance than CT in alleviating acute/subacute and chronic OVCFs pain for short and long-term. NB may be used as an alternative or before PVA, as far as pain relief is concerned. Various nonsurgery treatments including CT, PVA (PVP/PKP), NB, or a combination of these treatments are performed with the goal of reducing pain, stabilizing the vertebrae, and restoring mobility.

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A prospective randomized controlled study comparing the pain relief in patients with osteoporotic vertebral compression fractures with the use of vertebroplasty or facet blocking

Abstract: PVP produced better pain relief than FB in the short term (≤1 week). However, the difference in pain-relief between these two techniques was insignificant in the long term (follow-up between 1 month and 12 months).

Cited by 50 publications

References 26 publications

Conduct and reporting of a vertebroplasty trial warrants critical examination

Conduct and reporting of a vertebroplasty trial warrants critical examination

Comparison of the Efficacy Between Two Micro‐Operative Therapies of Old Patients With Osteoporotic Vertebral Compression Fracture: A Network Meta‐Analysis

Network meta-analysis of percutaneous vertebroplasty, percutaneous kyphoplasty, nerve block, and conservative treatment for nonsurgery options of acute/subacute and chronic osteoporotic vertebral compression fractures (OVCFs) in short-term and long-term effects

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