A Prospective, Randomized, Controlled Study to Evaluate the Efficacy and Tolerability of Ayurvedic Formulation “Varuna and Banana Stem” in the Management of Urinary Stones

Abstract

Our preliminary experience suggests that the Ayurvedic formulation "varuna and banana stem" has promise for the management of upper urinary-tract calculi, especially renal calculi. It helps to dissolve renal calculi and facilitate their passage. In addition, it also helps in reduction of pain due to renal/ureteric calculus disease. A larger phase III study with a longer follow-up is required.

Consensus of local knowledge on medicinal plants among traditional healers in Mayiladumparai block of Theni District, Tamil Nadu, India

“…(Gopi and Setty, 2010) (liver ailments), Gymnema sylvestre (Leach, 2007), Syzygium cumini (Helmstadter, 2008), Senna auriculata (Gupta et al, 2010) (diabetes), Euphorbia hirta (Galvez et al, 1993) (antidiarrheal), Musa paradisiaca (Patnakar et al, 2008), Aerva lanata (Soundararajan et al, 2006) (urinary ailments), Cissus quadrangularis , Solanum nigrum ) (gastrointestinal ailments), and Azadirachta indica (Goswami et al, 2010) (immune enhancer) had at least three citations for the same use and pharmacological support.…”

Documentation and quantitative analysis of the local knowledge on medicinal plants among traditional Siddha healers in Virudhunagar district of Tamil Nadu, India

“…This caused a high consensus for the medicinal plants that were prescribed as adjuvants. In urinary ailments group, the plants such as Tribulus terrestris (Aggarwal et al, 2010), Musa paradisiaca (Patnakar et al, 2008), Aerva lanata (Soundararajan et al, 2006), Asparagus racemosus (Christina et al, 2005) and Pedalium murex (Thamizhmozhi et al, 2009) were having pharmacological support.…”

Prospective randomized clinical trial comparing phytotherapy with potassium citrate in management of minimal burden (≤8 mm) nephrolithiasis

“…Thus, both our patient study groups showed a near equal efficacy in reducing serum UA levels. Published literature on KC therapy[57–1031] and PT[17–193233] has not demonstrated any effect on the serum UA levels. The reason(s) for the decline in the serum UA levels in our study are difficult to ascertain; however, we conjecture that this could be related to the general effect of KC on UA metabolism; alkalizing the urine by converting UA into urate ion and this urate ion passes into urine without its crystallization, thus decreasing the concentration of UA.…”

“…The decline in serum UA levels may be beneficial as it may lower the risk of UA stones; however, the urinary UA and pH levels may be other more critical criteria than serum UA alone. [252734] In patients with hyperuricemia due to high animal protein intake with a normal pH, the decrease in the serum UA level is proportionate to the decrease in the urinary UA,[33] which we believe may lower the risk of renal stone formation.…”