A prospective randomised study of dense Infinity cytological brush versus regularly used brush in pancreaticobiliary malignancy

Abstract

With the standardised technique, the sensitivity of brush cytology is fairly good. The dense Infinity® brush does not show any advantage regarding sensitivity compared with the conventional cytology brush.

Diclofenac Does Not Reduce the Risk of Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis in Low-Risk Units

“…In previous analyses, the risk of PEP in our unit has been 2.0-3.3%. 29,30 The sample size determination for this study was carried out as follows: power = 0.8; α = 0.05; and to lower the risk from 3.0 to 1.0% needs a sample of 1528 patients (764 + 764). We included 2000 patients in this study.…”

“…The annual volume in our unit is 1200 ERCP procedures, and the overall risk of PEP has varied between 2.0 and 3.3%. 29,30…”

Diagnostic yield and accuracy of a new cytology brush design compared to standard brush cytology for evaluation of biliary strictures

“…A similar prospective study of 60 patients with biliary strictures suspicious for malignancy randomized patients to either the Infinity brush ( n = 30) or a standard cytology brush ( n = 30) . Patients were followed for a median of 11 months and all of the patients were later diagnosed with malignancy.…”

“…A similar prospective study of 60 patients with biliary strictures suspicious for malignancy randomized patients to either the Infinity brush (n 5 30) or a standard cytology brush (n 5 30). 9 Patients were followed for a median of 11 months and all of the patients were later diagnosed with malignancy. The biliary brush cytology samples were graded by experienced pathologists using three categories: (1) Furthermore, the diagnostic accuracy of the standard brush was significantly better than the Infinity brush.…”

Agreement between endoscopic ultrasound-guided fine-needle aspiration and endobiliary brush cytology in suspected pancreaticobiliary malignancies

“…The authors concluded that the Infinity ERCP sampling device increases diagnostic accuracy, likely due to improved cellular yield 17 . However, a 2015 randomized controlled trial also compared the Infinity ERCP sampling device against a traditional brush in the setting of a suspected malignant biliary stricture, and found a higher cancer detection rate and sample quality with the traditional brush 18 .…”