A prospective randomised controlled trial comparing daily, alternate day and PRN lansoprazole in the maintenance treatment of eosophagitis

Evidence‐Based Choice of Esophageal Stent for the Palliative Management of Malignant Dysphagia

“…Twelve studies published between 1993 and 2003 matched our inclusion criteria, comparing 424 patients in the metal stents and 483 in the plastic group (total of 911 patients) [2,[12][13][14][15][16][17][18][19][20][21][22], whereas eight studies published between 1994 and 2005 compared 267 in the covered and 320 in the uncovered metal stents (total of 564 patients) [23][24][25][26][27][28][29][30]. Both reviewers had 100% agreement on data extraction.…”

Esomeprazole 20 mg on‐demand is more acceptable to patients than continuous lansoprazole 15 mg in the long‐term maintenance of endoscopy‐negative gastro‐oesophageal reflux patients: the COMMAND Study

“…Studies investigating less than daily dosing with lansoprazole have only been reported in patients with erosive RO (not ENRD). These studies concluded that alternate day dosing with either 15 or 30 mg lansoprazole or prn dosing with 30 mg lansoprazole was less effective than continuous dosing with 15 mg daily in controlling symptoms and the underlying oesophagitis 16–18 . In these studies, the reduction in the number of capsules consumed was at the expense of a slight increase in the rate of endoscopic relapse (of oesophagitis) and less effective symptom control.…”