A prospective randomised clinical study on evaluation of platelet‐rich fibrin versus zinc oxide eugenol in the management of alveolar osteitis

Abstract

Purpose: The aim of this study was to evaluate the efficacy of plateletrich fibrin (PRF) in the management of alveolar osteitis and further compare the results with those of zinc-oxide Eugenol (ZOE). Materials and methods: A total of 40 patients with alveolar osteitis following extraction of mandibular molars were randomly divided into two groups on the basis of treatment, in which Group A patient's received PRF and Group B received ZOE as an obtundant dressing. Pain (VAS), degree of inflammation and number of exposed socket walls were noted and evaluated at 1st, 3rd, 5th and 7th post-operative day. Results: Group A showed better and faster socket healing than Group B. However, symptomatic pain relief was faster in Group B than in Group A. Conclusion: PRF might be a treatment of choice in the management of alveolar osteitis. Clinical relevanceScientific rationale for study PRF is a healing bio-material. The rationale for using PRF in our study was based on previous studies, which showed the potential of PRF in the process of bone and soft tissue healing. Principal findingsIn our study, we found that PRF was better and faster than standard ZOE dressing in terms of reduction of inflammation and socket healing and equally effective as ZOE dressing in terms of pain control, in case of alveolar osteitis. Practical implicationsPRF has a simple and inexpensive processing, without biochemical blood handling. There is virtually no risk of allergic reactions. So, PRF might be a good alternative to ZOE in the management of alveolar osteitis.

Platelet-rich fibrin in oral surgical procedures: a systematic review and meta-analysis

“…11,47 For quantitative analysis 13 articles were included, 9 articles about third molar 8, 25, 26, 28, 29, 32, 48-50 , 2 articles about sinus lift 35, 38 and 2 articles about dental implants 46, 51 . Seventeen articles were excluded and the reasons for exclusion were as follows: 4 non-randomized controlled clinical trial 52-55 ; 4 studies which outcomes of interest were not reported [56][57][58][59] ; 2 studies that used other PRF protocol 60,61 ; 1 study which did not test PRF 62 ; 1 retrospective study 63 ; 2 prospective studies 64,65 ; 1 study that used the same patients sample as other studies 66 ; 1 full text was not found 67 ; and 1 study was written in persa and not translated 68 . The value of Kappa was 0.84, thus it was considered an excellent agreement.…”

Hyaluronic Acid-Based Medical Device for Treatment of Alveolar Osteitis—Clinical Study

“…In addition to the medical history criteria, the study’s subject pool excluded pregnant and lactating women, heavy smokers (more than 10 cigarettes per day), and people using illicit drugs. The study-subject selection criteria, clinical, and analytical methods mirrored previous research to allow comparison [27].…”

Comparison of platelet‐rich fibrin with zinc oxide eugenol in the relief of pain in alveolar osteitis

“…This is in agreement with previous studies where the common age group was reported in the range of 30 to 40 years. 14 , 16 However, some studies have reported a peak incidence in the second decade. 31 , 32…”

“…5. Estimation of sample size 16 where Z ∞ = 1.96 for ∞ = 0.05, Z β = 0.84 for β = 0.20, Δ = μ T − μ C (difference in mean). σ = SD.…”

“…15 PRF is a tetra molecular polymer gel that incorporates platelets, leukocytes, cytokines, growth factors, and circulating stem cells into its matrix, which can accelerate physiologic wound healing and the formation of new bone. 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 The use of PRF has been postulated to accelerate the healing process of the extraction socket and in turn reduce postoperative pain. 26 , 27 …”