A prospective ophthalmic evaluation of patients with acute myeloid leukemia: correlation of ocular and hematologic findings.

Abstract

We report the results of a prospective 2-year study of the ocular manifestations of myeloid leukemia. Fifty-three patients underwent complete ophthalmic evaluation prior to the initiation of treatment as well as during the course of their disease. All ocular abnormalities were confined to the retina and optic nerve and were present in 34 patients, 30 of whom had either hemorrhages or cotton-wool spots alone or in combination. These findings were unrelated to age, sex, French-American-British (FAB) classification, and pretreatment leukocyte count or hematocrit. Patients with retinopathy had significantly lower platelet counts than those without retinopathy. Three patients had funduscopic evidence of optic nerve edema. None of these had clinical evidence of CNS leukemia. The presence of retinopathy was unrelated to therapeutic response. There was complete resolution of all ocular findings in those patients surviving the induction phase of therapy.

Retinopathy in acute leukaemia at initial diagnosis: correlation of fundus lesions and haematological parameters

“…Therefore, we feel that the correlation of haematological parameters with the occurrence of retinal lesions was appropriate. Other researchers have noted an association between anaemia and the presence of retinal haemorrhages (Gibson 1938;Culler 1954;Dwivedi et al 1986;Karesh et al 1989;Guyer et al 1989;Abu el-Asrar et al 1996). However, no significant association between anaemia and the occurrence of IRH (1996) reported that ALL patients with cotton-wool spots had significantly lower haemoglobin levels than patients without such lesions.…”

Infiltração conjuntival como primeira manifestação de leucemia mielóide aguda: relato de caso

“…Geralmente envolve os tecidos oculares mais tardiamente sendo a retina, órbita, nervo óptico e trato uveal os locais mais acometidos [3][4][5] .…”

“…Alterações retinianas ocorrem em 30% a 90% dos casos de leucemia 3,4 . Dilatações e aumento de tortuosidade dos vasos e hemorragias retinianas são os achados mais comuns.…”

“…São feitas considerações a respeito das manifestações sistêmicas e oftalmológicas e atualização desta doença. (1) Residente do Terceiro ano do Departamento de Oftalmologia da EPM-UNIFESP (2) Doutora em Oftalmologia do Setor de Doenças Externas do Departamento de Oftalmologia da EPM-UNIFESP (3) Médica voluntária do Departamento de Oftalmologia da EPM-UNIFESP (4) Professor Assistente do Departamento de Anatomia Patológica da EPM-UNIFESP (5) Pós-graduanda da Disciplina de Hematologia do Departamento de Clínica Médica da EPM-UNIFESP (6) Ciro Massaiuki Komagome (1 ) Luciene Barbosa de Sousa (2 ) Maria do Carmo Pinheiro (3 ) Moacyr Rigueiro (4 ) Isabel Cristina Proença Gil (5 ) Denise de Freitas (6 ) RESUMO Palavras-chave: Leucemia mielóide; Infiltração; Conjuntiva; Cloroma; Sarcoma granulocítico.…”

Ophthalmic manifestation of leukemia

“…В научной литературе имеются проспективные исследова-ния, доказывающие последнее утверждение [87]. От 14 до 53 % пациентов с лейкозом имеют оф-тальмологические проявления заболевания уже на момент постановки онкогематологического диагноза [52]. При посмертном гистологическом исследовании глазного яблока и орбиты специ-фические изменения обнаруживаются в 28-80 % [55].…”