A prospective, open, single blind, randomized study comparing four analgesics in the treatment of peripheral injury in the emergency department

Hoogewijs, Jan; Mw, Diltoer; Hubloue, Ives; Hd, Spapen; Camu, F.; Corne, Luc; Lp, Huyghens

doi:10.1097/00063110-200006000-00006

Cited by 33 publications

(27 citation statements)

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“…14 Another single-blind, randomized study trial (160 subjects) compared intravenous propacetamol (a prodrug of paracetamol) with nonsteroidal antiinflammatory drugs and showed that the prodrug was at least as efficacious as nonsteroidal antiinflammatory drugs in the emergency treatment of peripheral injury. 15 Nonsteroidal antiinflammatory drugs have been shown to cause more gastroduodenal injury than paracetamol or placebo. 16 At follow-up, there appeared to be no difference in wound healing between the different groups, no difference in return to normal function, no difference in requirement for absence from work, no difference in reattendance rates to the ED, and no difference in the use of nonconventional medicines between the 4 groups.…”

Section: Discussionmentioning

confidence: 99%

Randomized Double-Blind Trial Comparing Oral Paracetamol and Oral Nonsteroidal Antiinflammatory Drugs for Treating Pain After Musculoskeletal Injury

Woo

Man

Lam

et al. 2005

Annals of Emergency Medicine

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Section: Discussionmentioning

confidence: 99%

Randomized Double-Blind Trial Comparing Oral Paracetamol and Oral Nonsteroidal Antiinflammatory Drugs for Treating Pain After Musculoskeletal Injury

Woo

Man

Lam

et al. 2005

Annals of Emergency Medicine

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“…A single-blind emergency department study of 160 patients presenting with an isolated peripheral injury found that intravenous propacetamol, tramadol and diclofenac were all equally effective 8. This is the first published study to compare intravenous paracetamol with intravenous morphine for isolated limb trauma in the emergency department.…”

Section: Introductionmentioning

confidence: 91%

Randomised comparison of intravenous paracetamol and intravenous morphine for acute traumatic limb pain in the emergency department

et al. 2011

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“…Results of the similar studies did not show any significant difference in the analgesic effect of intravenous acetaminophen and morphine (3)(4)(5)(6)(7)(8)(9).…”

Section: Discussionmentioning

confidence: 79%

“…A single-blind emergency department study over patients presenting with renal colic found that intravenous acetaminophen was equally effective as intravenous morphine (3). There are also some other studies showing that intravenous acetaminophen is as effective as intravenous morphine in pain management (4)(5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Intravenous Acetaminophen Versus Intravenous Morphine Sulfate for Isolated Diaphyseal Long Bone Fractures: A Randomized Clinical Trial

Deloee¹,

Zarmehri²,

Pishbin³

et al. 2017

Trauma Mon

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Objectives: Pain management is an important issue in traumatic patients. The aim of this randomized clinical trial was to compare the analgesic effect of intravenous acetaminophen with intravenous morphine sulfate in patients with traumatic diaphyseal long bone fracture. Methods: This double-blind randomized clinical trial was carried out in an academic trauma center in Mashhad, Iran, from February to October 2013. After primary modalities like limb elevation, ice and limb splinting, patients were allocated to receive either acetaminophen 15 mg/kg or morphine sulfate 0.1 mg/kg randomly. The pain severity was measured using a visual analogue scale before drug administration and 5 and 30 minutes after drug administration. Then, the results were compared. Results: Of the 50 patients recruited over 9 months 26 patients received intravenous morphine sulfate and 24 patients received intravenous acetaminophen. A significant difference was observed between the two groups at 5 minutes after drug administration; the morphine sulfate group showed more reduction in pain severity after 5 minutes (P < 0.0001). However, there was no significant difference in pain severity at 30 minutes after drug administration between the two groups (P = 0.85). Conclusions: It seems that after 30 minutes, intravenous acetaminophen is as effective as intravenous morphine sulfate in pain management of isolated diaphyseal long bone fracture. However, it should be noted that the analgesic effect of acetaminophen begins with a delay. Thus, we suggest using intravenous acetaminophen when morphine administration is contraindicated.

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A prospective, open, single blind, randomized study comparing four analgesics in the treatment of peripheral injury in the emergency department

Cited by 33 publications

References 0 publications

Randomized Double-Blind Trial Comparing Oral Paracetamol and Oral Nonsteroidal Antiinflammatory Drugs for Treating Pain After Musculoskeletal Injury

Randomized Double-Blind Trial Comparing Oral Paracetamol and Oral Nonsteroidal Antiinflammatory Drugs for Treating Pain After Musculoskeletal Injury

Randomised comparison of intravenous paracetamol and intravenous morphine for acute traumatic limb pain in the emergency department

Intravenous Acetaminophen Versus Intravenous Morphine Sulfate for Isolated Diaphyseal Long Bone Fractures: A Randomized Clinical Trial

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