A prospective observational study of retinopathy of prematurity in a tertiary care centre with respect to its incidence, risk factors and short term outcomes

Kothuri, Manohar Sai; Malshe, Nandini; Lalwani, Sanjay

doi:10.4038/sljch.v46i4.8382

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…In our study, the prevalence of retinopathy of prematurity was 17 (28%). This was in concurrence with study by Manohar et al, 13 conducted at Pune, where the incidence was 19.9% and study by Gupta et al, 14 of 60 babies, found incidence of ROP at 21.7%. In a study done by Anudeep et al, out of the 65 preterm babies screened, 24 (37%) developed ROP.…”

Section: Discussionsupporting

confidence: 90%

Prevalence and risk factors of retinopathy of prematurity inWestern Maharashtra

Kaul¹,

Magdum²,

Mohan³

et al. 2021

IJCEO

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Background: ROP is a disease of the developing immature blood vessels in the retina of premature new born by toxicity of oxygen. With the recent advances in neonatal care there has been improvement in rates of survival in premature infants. Factors playing a role in ROP are low gestational age, low birth weight and increased oxygen supplementation after birth. Aims: To study the prevalence of retinopathy of prematurity and to determine its risk factors. Materials and Methods: A prospective study was conducted in a tertiary centre from September 2018 to August 2020. 60 babies were screened with birth weight less than 1500 gms and gestational age less than 32 weeks. History was taken from parents and fundus examination was done. The grading of stages and zones was done. Data was entered in Excel and tests of statistical significance were used. Results: The prevalence of ROP was 28%. ROP was seen in zone III in 70% and 47% had stage 2 ROP. Only 7% mothers had completed less than 28 weeks of gestation. The mean birth weight was 1.36 kgs. 71% of the ROP positive babies were delivered by normal vaginal delivery. 100% babies diagnosed with ROP had been subjected to oxygen supplementation. 47% babies developed sepsis whereas 76% babies had history of RDS. Conclusion: ROP is a preventable cause of blindness in childhood. Early screening by an ophthalmologist is important to prevent this. The burden of ROP is bound to rise due to increased advances in the field of neonatology if screening protocols are not implemented stringently.

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Section: Discussionsupporting

confidence: 90%

Prevalence and risk factors of retinopathy of prematurity inWestern Maharashtra

Kaul¹,

Magdum²,

Mohan³

et al. 2021

IJCEO

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Retinopathy of prematurity: A revisit to the incidence, risk factors, and its response to laser therapy

Kubrey¹,

Panakkal

Kumar³

et al. 2022

IJCEO

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: The debilitating vasoproliferative retinal disorder retinopathy of prematurity (ROP), a prequel to neonatal blindness is known to be increasing in recent years with improved advances in neonatal care and survival. Aim of this study was to study the incidence of ROP, risk factors, and response to the gold standard treatment of laser has been explored in this study.: In this prospective observational study of all neonates referred to the retina clinic of a tertiary care centre, from both in-house referrals and peripheral centres. Demographic data, both maternal and neonatal data were recorded. Neonates complying to inclusion and exclusion criteria were examined under 28 diopter lens and all ROP were documented using RetCam. Laser photocoagulation was performed and later followed up according to ETROP schedule.: 699 neonates were screened in the study and ROP was detected in 13.73% (182/1398) of this population, with mean gestational age 31.82±2.44 weeks and mean birth weight 1425.36±287.73 grams. Neonatal risk factors of gestational age <34 weeks, low birth weight, ventilatory support, RDS, oxygen supplementation, sepsis, birth asphyxia, blood transfusion, and phototherapy were found to have significant association for incidence of ROP and those requiring treatment. When 67.58% regressed spontaneously, all 59 eyes requiring treatment underwent laser therapy. 46 out of these 59 eyes (77.97%) showed regression and remaining seven eyes required further intervention.: Better premature neonates survival rates has shown an increased incidence of ROP over the past decades. Red flag signs like low gestational age, low birth weight, RDS, oxygen supplementation, sepsis, blood transfusion, AGA and twin pregnancy are confirmed to have significant association with the development of ROP. Laser therapy still remains effective in controlling progression of the disease.

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Retinopathy of Prematurity: Incidence and Risk Factor Analysis in Small for Gestational Age Neonates Compared to Appropriate for Gestational Age

Arora

Mahapatra

Arora

2023

Journal of Pharmacy and Bioallied Sciences

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Objective: To analyze the incidence of retinopathy of prematurity (ROP) among preterm neonates who were born small for gestational age (SGA) and appropriate for gestational age (AGA). Materials and Methods: A prospective cohort study among preterm neonates born <34 weeks of gestational age (GA) and <2000 grams birth weight (BW) was conducted. The neonates were divided into AGA and SGA group. Incidence of ROP and risk factors was compared among the groups. Result: 290 neonates were screened [AGA: 240 (82.8%); SGA: 50 (17.2%)]. The mean birth-weight and gestational age were 1510.7 ± 390.64 grams and 31.4 ± 4.8 weeks, respectively. The incidence of ROP in AGA and SGA was 30.2% and 33%, respectively (P = 0.58), whereas the incidence of type 1 ROP in AGA and SGA was 14% and 19% (P = 0.41). Male sex, anemia, oxygen administration, surfactant administration, sepsis, and PIH were independent significant risk factors for ROP on multivariate analysis. Conclusion: This study showed that both AGA and SGA premature infants have similar incidence of ROP. SGA is not an independent risk factor for ROP.

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A prospective observational study of retinopathy of prematurity in a tertiary care centre with respect to its incidence, risk factors and short term outcomes

Cited by 3 publications

References 9 publications

Prevalence and risk factors of retinopathy of prematurity inWestern Maharashtra

Prevalence and risk factors of retinopathy of prematurity inWestern Maharashtra

Retinopathy of prematurity: A revisit to the incidence, risk factors, and its response to laser therapy

Retinopathy of Prematurity: Incidence and Risk Factor Analysis in Small for Gestational Age Neonates Compared to Appropriate for Gestational Age

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