A prospective observational study of the clinical and pathological impact of stereotactic body radiotherapy (SBRT) as a neoadjuvant strategy of chemoradiation in pancreatic cancer

Chen-Zhao, X.; Hernando, O.; López, M.; Sánchez, E.; Montero, Á.; Garcia-Aranda, M.; Ciérvide, R.; Valero, J.; Alonso, R.; Cárdenas-Rebollo, José Miguel; Vicente, Emilio; Quijano, Yolanda; Cubillo, Antonio; Álvarez, Rafael; Prados, Susana; Plaza, Carlos; García, Juan Diego Mediavilla; Zucca, D.; Fernandez-Leton, P.; Rubio, Carmen

doi:10.1007/s12094-020-02287-w

Cited by 15 publications

(17 citation statements)

References 24 publications

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“…To the best of our knowledge, few experiences of SBRT in resectable PDAC have been reported, including two reports published in 2020 [101,102]. The first is a prospective study from a Spanish group [101] including 45 PC patients treated with preoperative CT and SBRT. Only five patients were considered resectable, and four of them underwent radical surgery after CT and SBRT.…”

Section: Resectable Pancreatic Cancermentioning

confidence: 99%

Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines

Cellini

Arcelli

Simoni

et al. 2020

Cancers

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Pancreatic cancer represents a modern oncological urgency. Its management is aimed to both distal and local disease control. Resectability is the cornerstone of treatment aim. It influences the clinical presentation’s definitions as up-front resectable, borderline resectable and locally advanced (unresectable). The main treatment categories are neoadjuvant (preoperative), definitive and adjuvant (postoperative). This review will focus on (i) the current indications by the available national and international guidelines; (ii) the current standard indications for target volume delineation in radiotherapy (RT); (iii) the emerging modern technologies (including particle therapy and Magnetic Resonance [MR]-guided-RT); (iv) stereotactic body radiotherapy (SBRT), as the most promising technical delivery application of RT in this framework; (v) a particularly promising dose delivery technique called simultaneous integrated boost (SIB); and (vi) a multimodal integration opportunity: the combination of RT with immunotherapy.

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Section: Resectable Pancreatic Cancermentioning

confidence: 99%

Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines

Cellini

Arcelli

Simoni

et al. 2020

Cancers

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“…pancreatic cancer is one of the most devastating malignancies, with a 5-year OS rate of less than 5% ( 108 ). Currently, treatment is dependent on surgical resection.…”

Section: Dissecting the Roles Of Ldl And Ox-ldl In Particular Types O...mentioning

confidence: 99%

Involvement of LDL and ox-LDL in Cancer Development and Its Therapeutical Potential

et al. 2022

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Lipid metabolism disorder is related to an increased risk of tumorigenesis and is involved in the rapid growth of cancer cells as well as the formation of metastatic lesions. Epidemiological studies have demonstrated that low-density lipoprotein (LDL) and oxidized low-density lipoprotein (ox-LDL) are closely associated with breast cancer, colorectal cancer, pancreatic cancer, and other malignancies, suggesting that LDL and ox-LDL play important roles during the occurrence and development of cancers. LDL can deliver cholesterol into cancer cells after binding to LDL receptor (LDLR). Activation of PI3K/Akt/mTOR signaling pathway induces transcription of the sterol regulatory element-binding proteins (SREBPs), which subsequently promotes cholesterol uptake and synthesis to meet the demand of cancer cells. Ox-LDL binds to the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and cluster of differentiation 36 (CD36) to induce mutations, resulting in inflammation, cell proliferation, and metastasis of cancer. Classic lipid-lowering drugs, statins, have been shown to reduce LDL levels in certain types of cancer. As LDL and ox-LDL play complicated roles in cancers, the potential therapeutic effect of targeting lipid metabolism in cancer therapy warrants more investigation.

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“…Pancreatic cancer is a highly malignant tumor [1] with the highest mortality rate (ca. 100%) and the lowest 5-year survival rate (≤5%) when all stages are combined [2,3]. Since no significant symptoms appear until the late stage of pancreatic cancer, the development of early diagnosis methods is of importance.…”

Section: Introductionmentioning

confidence: 99%

Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy

Liang¹,

Liu²,

Wang³

et al. 2021

Beilstein J. Nanotechnol.

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The mechanical properties of cells are key to the regulation of cell activity, and hence to the health level of organisms. Here, the morphology and mechanical properties of normal pancreatic cells (HDPE6-C7) and pancreatic cancer cells (AsPC-1, MIA PaCa-2, BxPC-3) were studied by atomic force microscopy. In addition, the mechanical properties of MIA PaCa-2 after treatment with different concentrations of doxorubicin hydrochloride (DOX) were also investigated. The results show the Young's modulus of normal cells is greater than that of three kinds of cancer cells. The Young's modulus of more aggressive cancer cell AsPC-1 is smaller than that of less aggressive cancer cell BxPC-3. In addition, the Young's modulus of MIA PaCa-2 rises with the increasing of DOX concentration. This study may provide a new strategy of detecting cancer, and evaluate the possible interaction of drugs on cells.

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A prospective observational study of the clinical and pathological impact of stereotactic body radiotherapy (SBRT) as a neoadjuvant strategy of chemoradiation in pancreatic cancer

Cited by 15 publications

References 24 publications

Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines

Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines

Involvement of LDL and ox-LDL in Cancer Development and Its Therapeutical Potential

Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy

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