A prospective multicentre observational study of Permacol^™ collagen paste for anorectal fistula: preliminary results

Abstract

Permacol paste is shown to be effective in treating primary and recurrent cryptoglandular anorectal fistula with minimal unwanted side effects.

Final results of a European, multicentre, prospective, observational study of Permacol™ collagen paste injection for the treatment of anal fistula

“…In fact, the majority of those who healed after 12 months had done so after 1 month. These final results are largely unchanged from the 54% healing rate of the initial 30 patients reported previously from this study . Pain levels were also satisfactory, with 87.7% of all patients experiencing no, or only mild, pain after 1 month.…”

“…Patients with a clinical diagnosis of cryptoglandular anal fistula were invited to take participate. Inclusion and exclusion criteria have been described in a previous study . Patients with a solitary, primary or recurrent transsphincteric or intersphincteric fistula tract of cryptoglandular origin were eligible.…”

Association of Coloproctology of Great Britain and Ireland consensus exercise on surgical management of fistulating perianal Crohn's disease

“…These therapies have been used in Crohn's disease in small numbers, with success rates of 54%, 83%, 71% and 57%, respectively, and little in the way of adverse outcomes . As yet, no large randomized controlled trials have reported on their use in fpCD.…”

Review article: pathogenesis of Crohn's perianal fistula—understanding factors impacting on success and failure of treatment strategies

“…However, results are variable and a subsequent randomised controlled trial of plug vs seton removal alone in Crohn's perianal fistula did not show any advantage to using the plug as an adjunct to healing . An alternative biological infill technique is with Permacol paste that may theoretically fill the spaces within a track more fully than a plug . This in turn may mitigate against recurrence although evidence to support this in Crohn's or non‐Crohn's fistulae is lacking.…”

“…82 An alternative biological infill technique is with Permacol paste that may theoretically fill the spaces within a track more fully than a plug. 83 This in turn may mitigate against recurrence although evidence to support this in Crohn's or non-Crohn's fistulae is lacking.…”