A Prospective, Multicenter, Single-Arm Clinical Trial for Treatment of Complex Diabetic Foot Ulcers with Deep Exposure Using Acellular Dermal Matrix

Cazzell, Shawn; Moyer, Peter M; Samsell, Brian; Dorsch, Kimberly; McLean, Julie; Moore, Mark A.

doi:10.1097/01.asw.0000569132.38449.c0

Cited by 28 publications

(21 citation statements)

References 14 publications

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“…In addition, during the development of diabetic foot, skin breakage and infection are the main causes of foot ulcers. Due to insufficient blood supply and nutrition to the lower limbs in the presence of a foot lesion, wound healing is difficult, and patients are required to fully understand how to care for their foot and prevent foot injuries[ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Observation of the effect of one-to-one education on high-risk cases of diabetic foot

Fu¹,

Hu²,

Peng³

et al. 2021

WJCC

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BACKGROUND Diabetes is a common chronic disease, and its global incidence is on the rise. The disease is directly attributed to insufficient insulin efficacy/secretion, and patients are often accompanied by multiple complications. Diabetic foot is one of the most common complications of diabetes. Diabetic feet have ulcers and infections, which can eventually lead to amputation. Basic nursing care, such as lowering blood pressure and preventing foot skin infections in clinical nursing work, has positive significance for the prevention and control of diabetic feet. AIM To explore the positive significance of one-to-one education in high-risk cases of diabetic foot. METHODS This observation included 98 high-risk cases of diabetic foot in our hospital during the period from August 2017 to October 2019, and these patients were randomly divided into the basic nursing group and the one-to-one education group with 49 patients per group. The basic nursing group only received routine basic nursing, while the one-to-one education group gave patients one-to-one education on the basis of basic nursing. After nursing, the self-care ability and compliance behavior of the two groups were evaluated and compared between these two groups. The knowledge mastery of the patient and the satisfaction of nursing were accounted. RESULTS The assessment results of patients (self-care responsibility, self-care skills, self-concept and self-care knowledge) were significantly higher in the one-to-one education group than in the basic nursing group. The scores of compliance behaviors (foot bathing, shoes and socks selection, sports health care) in the one-to-one education group were significantly higher than those in the basic nursing group. Patients in the one-to-one education group had a significantly higher level of knowledge mastery and satisfaction of nursing than the basic nursing group. CONCLUSION One-to-one education for high-risk cases of diabetic foot is helpful to improve the cognition and self-care ability of patients with diabetic foot, to ensure that patients follow the doctor’s advice of self-care and to improve their nursing satisfaction.

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Section: Discussionmentioning

confidence: 99%

Observation of the effect of one-to-one education on high-risk cases of diabetic foot

Fu¹,

Hu²,

Peng³

et al. 2021

WJCC

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“…Produced from human or animal skin, ADM is favorable for full-thickness skin wound healing and can reduce scar tissue formation [21,[30][31][32]. After transplantation in the wound bed, ADM enhances the synthesis of hyaluronic acid and induces wound angiogenesis [29,33,34].…”

Section: Acellular Dermal Matrix (Adm)mentioning

confidence: 99%

Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing

Huang

Xie

et al. 2021

Pharmaceutics

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Membranous extracellular matrix (ECM)-based scaffolds are one of the most promising biomaterials for skin wound healing, some of which, such as acellular dermal matrix, small intestinal submucosa, and amniotic membrane, have been clinically applied to treat chronic wounds with acceptable outcomes. Nevertheless, the wide clinical applications are always hindered by the poor mechanical properties, the uncontrollable degradation, and other factors after implantation. To highlight the feasible strategies to overcome the limitations, in this review, we first outline the current clinical use of traditional membranous ECM scaffolds for skin wound healing and briefly introduce the possible repair mechanisms; then, we discuss their potential limitations and further summarize recent advances in the scaffold modification and fabrication technologies that have been applied to engineer new ECM-based membranes. With the development of scaffold modification approaches, nanotechnology and material manufacturing techniques, various types of advanced ECM-based membranes have been reported in the literature. Importantly, they possess much better properties for skin wound healing, and would become promising candidates for future clinical translation.

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“…In a prospective, multicenter, single-arm clinical trial for the treatment of large complex DFUs with exposed tendon or bone, DermACELL™ rapidly reduced the size of the wound. However, that study favored cases that required a single application of the ADM [41]. Additionally, in a case report [40], DermACELL™ was successfully used to treat a patient with scarring from a severe burn.…”

Section: Dermacell™ (Lifenet Health)mentioning

confidence: 99%

Decellularized Scaffolds for Skin Repair and Regeneration

Dussoyer

Michopoulou²,

Rousselle

2020

Applied Sciences

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The skin is the largest organ in the body, fulfilling a variety of functions and acting as a barrier for internal organs against external insults. As for extensive or irreversible damage, skin autografts are often considered the gold standard, however inherent limitations highlight the need for alternative strategies. Engineering of human-compatible tissues is an interdisciplinary and active field of research, leading to the production of scaffolds and skin substitutes to guide repair and regeneration. However, faithful reproduction of extracellular matrix (ECM) architecture and bioactive content capable of cell-instructive and cell-responsive properties remains challenging. ECM is a heterogeneous, connective network composed of collagens, glycoproteins, proteoglycans, and small molecules. It is highly coordinated to provide the physical scaffolding, mechanical stability, and biochemical cues necessary for tissue morphogenesis and homeostasis. Decellularization processes have made it possible to isolate the ECM in its native and three-dimensional form from a cell-populated tissue for use in skin regeneration. In this review, we present recent knowledge about these decellularized biomaterials with the potential to be used as dermal or skin substitutes in clinical applications. We detail tissue sources and clinical indications with success rates and report the most effective decellularization methods compatible with clinical use.

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A Prospective, Multicenter, Single-Arm Clinical Trial for Treatment of Complex Diabetic Foot Ulcers with Deep Exposure Using Acellular Dermal Matrix

Cited by 28 publications

References 14 publications

Observation of the effect of one-to-one education on high-risk cases of diabetic foot

Observation of the effect of one-to-one education on high-risk cases of diabetic foot

Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing

Decellularized Scaffolds for Skin Repair and Regeneration

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