A prospective multicenter randomized clinical trial of autogenous bone versus β-tricalcium phosphate graft alone for bilateral sinus elevation: Histologic and histomorphometric evaluation

Szabó, György; Huys, Luc; Coulthard, Paul; Maiorana, Carlo; Garagiola, U.; Barabás, József; Németh, Zoltán; Hrabák, Károly; Suba, Zsuzsanna

doi:10.1016/j.prosdent.2005.09.005

Cited by 98 publications

(214 citation statements)

References 0 publications

Supporting

Mentioning

178

Contrasting

Unclassified

Order By: Relevance

“…SZABO et al 27 showed after a 6 month healing period comparable results for both groups. ZERBO et al 39 and ZIJDERVELD et al 40 concluded that in the controls, augmented with autogenous bone, the newly formed bone was significantly higher than in the b-tricalciumphosphate group after the same healing period.…”

Section: Discussionmentioning

confidence: 81%

See 1 more Smart Citation

Maxillary sinus lift with solely autogenous bone compared to a combination of autogenous bone and growth factors or (solely) bone substitutes. A systematic review

Rickert¹,

Slater²,

Meijer³

et al. 2012

International Journal of Oral and Maxillofacial Surgery

114

113

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 81%

“…b-Tricalciumphosphate (Cerasorb) was been used in the intervention groups in the studies by SUBA et al 26 , SZABO et al 27 , ZERBO et al 39 and ZIJDERVELD et al 40 . A meta-analysis of these revealed a significantly higher bone fraction 5-6 months after treatment when applying autogenous bone (P = 0.036).…”

Section: Histomorphometric Resultsmentioning

confidence: 99%

Maxillary sinus lift with solely autogenous bone compared to a combination of autogenous bone and growth factors or (solely) bone substitutes. A systematic review

Rickert¹,

Slater²,

Meijer³

et al. 2012

International Journal of Oral and Maxillofacial Surgery

114

113

View full text Add to dashboard Cite

show abstract

“…Maxillary sinus floor elevation (MSFE) is a widely accepted and routinely used pre-implant surgical procedure to increase bone height in the posterior maxilla (Tatum, 1986;Zijderveld et al, 2009). MSFE enables dental implant placement and provides a stable basis for these dental implants.…”

Section: Introductionmentioning

confidence: 99%

“…For bone reconstruction in the oral and maxillofacial region autologous bone is still the "gold standard" as grafting material. These bone grafts can be harvested from the iliac crest (Sindet-Pedersen and Enemark, 1990;Thorwarth et al, 2005), calvarium (Iturriaga and Ruiz, 2004), tibia (Jakse et al, 2001), rib (Borstlap et al, 1990) or intraoral donor sites such as the maxillary tuberosity, the retromolar area of the mandible (Thorwarth et al, 2005;Becktor et al, 2008) or chin (Borstlap et al, 1990). Autologous bone grafts have excellent osteoinductive, osteoconductive, and osteogenic properties (Oppenheimer et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Calcium phosphate ceramics are very similar to the inorganic components of natural bone and therefore highly biocompatible. The use of a membrane covering the lateral window of the maxillary sinus was suggested to be considered for all MSFE procedures (Tarnow et al, 2000). Moreover, a systematic review concluded that the use of a barrier membrane increases the survival rate of endosseous dental implants in the grafted maxillary sinus (Wallace and Froum, 2003).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A novel approach revealing the effect of a collagenous membrane on osteoconduction in maxillary sinus floor elevation with β-tricalcium phosphate

Schulten

Prins²,

Overman

et al. 2013

eCM

View full text Add to dashboard Cite

Calcium phosphates are used in maxillary sinus floor elevation (MSFE) procedures to increase bone height prior to dental implant placement. Whether a collagenous barrier membrane coverage of the lateral window affects bone formation within a bone substitute augmentation is currently an important matter of debate, since its benefit has not been irrefutably proven. Therefore, in this clinical study twelve patients underwent an MSFE procedure with β-tricalcium phosphate (β-TCP). The lateral window was either left uncovered, or covered with a resorbable collagenous barrier membrane. After a 6-months healing period, bone biopsies were retrieved during implant placement. Consecutive 1 mm regions of interest of these biopsies were assessed for bone formation, resorption parameters, as well as bone architecture using histology, histomorphometry and micro-computed tomography. Comparable outcomes between the groups with and without membrane were observed regarding osteoconduction rate, bone and graft volume, osteoclast number and structural parameters of newly formed bone per region of interest. However, osteoid volume in grafted maxillary sinus floors without membrane was significantly higher than with membrane.In conclusion, our results -obtained with a novel method employed using 1 mm regions of interest -demonstrate that the clinical application of a bioresorbable collagenous barrier membrane covering the lateral window, after an MSFE procedure with β-TCP, was not beneficial for bone regeneration and even decreased osteoid production which might lead to diminished bone formation in the long run.

show abstract

Effect of rapidly resorbable bone substitute materials on the temporal expression of the osteoblastic phenotype in vitro

Knabe

Houshmand

Berger

et al. 2007

J Biomedical Materials Res

View full text Add to dashboard Cite

Ideally, bioactive ceramics for use in alveolar ridge augmentation should possess the ability to activate bone formation and, thus, cause the differentiation of osteoprogenitor cells into osteoblasts at their surfaces. Therefore, in order to evaluate the osteogenic potential of novel bone substitute materials, it is important to examine their effect on osteoblastic differentiation. This study examines the effect of rapidly resorbable calcium-alkali-orthophosphates on osteoblastic phenotype expression and compares this behavior to that of beta-tricalcium phosphate (TCP) and bioactive glass 45S5. Test materials were three materials (denominated GB14, GB9, GB9/25) with a crystalline phase Ca(2)KNa(PO(4))(2) and with a small amorphous portion containing either magnesium potassium phosphate (GB14) or silica phosphate (GB9 and GB9/25, which also contains Ca(2)P(2)O(7)); and a material with a novel crystalline phase Ca(10)[K/Na](PO(4))(7) (material denominated 352i). SaOS-2 human bone cells were grown on the substrata for 3, 7, 14, and 21 days, counted, and probed for an array of osteogenic markers. GB9 had the greatest stimulatory effect on osteoblastic proliferation and differentiation, suggesting that this material possesses the highest potency to enhance osteogenesis. GB14 and 352i supported osteoblast differentiation to the same or a higher degree than TCP, whereas, similar to bioactive glass 45S5, GB9/25 displayed a greater stimulatory effect on osteoblastic phenotype expression, indicating that GB9/25 is also an excellent material for promoting osteogenesis.

show abstract

A prospective multicenter randomized clinical trial of autogenous bone versus β-tricalcium phosphate graft alone for bilateral sinus elevation: Histologic and histomorphometric evaluation

Cited by 98 publications

References 0 publications

Maxillary sinus lift with solely autogenous bone compared to a combination of autogenous bone and growth factors or (solely) bone substitutes. A systematic review

Maxillary sinus lift with solely autogenous bone compared to a combination of autogenous bone and growth factors or (solely) bone substitutes. A systematic review

A novel approach revealing the effect of a collagenous membrane on osteoconduction in maxillary sinus floor elevation with β-tricalcium phosphate

Effect of rapidly resorbable bone substitute materials on the temporal expression of the osteoblastic phenotype in vitro

Contact Info

Product

Resources

About