A prospective multi-institutional validity study to evaluate the accuracy of clinical diagnosis of pathological stage III gastric cancer (JCOG1302A)

Fukagawa, Takeo; Katai, Hitoshi; Mizusawa, Junki; Nakamura, Kenichi; Sano, Takeshi; Terashima, Masanori; Ito, Seiji; Yoshikawa, Takaki; Fukushima, Noriyoshi; Kawachi, Yasuyuki; Kinoshita, Takahiro; Kimura, Yutaka; Yabusaki, Hiroshi; Nishida, Yasunori; Iwasaki, Yoshiaki; Lee, Sang‐Woong; Yasuda, Takashi; Sasako, Mitsuru

doi:10.1007/s10120-017-0701-1

Cited by 114 publications

(84 citation statements)

References 20 publications

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“…They reported accuracy for T and N staging by SL. Preoperative T and N staging has a solid limitation due to the discrepancy between clinical and pathological diagnosis, and SL could not solve this problem. Not only that, SL has a potential disadvantage for T and N staging different from imaging, because it cannot provide complete exploration of the primary lesion and regional lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

Role of staging laparoscopy for gastric cancer patients

Fukagawa

2019

Annals of Gastroent Surgery

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Staging laparoscopy (SL) is frequently carried out in patients with advanced gastric cancer. However, some clinical questions are being debated and consensus must be obtained. With this aim, a literature search of PubMed/MEDLINE was carried out using the keywords “gastric cancer,” “SL,” and “diagnostic laparoscopy”. Articles published online up to February 2019 were analyzed, focusing on the following questions. (i) What is an adequate indication for SL? (ii) How do you carry out SL? (iii) Does SL provide accurate information about peritoneal dissemination? (iv) Is the yield of SL different by tumor location? (v) Is SL a safe procedure? (vi) Is “repeat SL” needed? (vii) Does SL provide oncological benefit? Results provided the following responses: (i) In Western countries, clinically resectable advanced tumor is an indication for SL. Terms to be introduced for adequate indication include “location,” “type 4 (linitis feature),” “large tumor,” “equivocal computed tomography (CT] findings,” and “lymph node swelling”. (ii) Exploration of the entire peritoneal cavity is preferable. (iii) Detection rate of peritoneal disease is 43%‐52% in Japanese institutions and 7.8%‐40% in other countries. False‐negative findings during SL were 0%‐17%, and 10%‐13% when limited to cytology. (iv) Yield of SL was higher in gastric cancer compared with esophagogastric junctional tumor. (v) SL‐related complications were estimated to occur in 0.4%. (vi) Repeat SL is important after treatment. (vii) If the efficacy of neoadjuvant chemotherapy for patients with P0CY1 is established, SL can provide oncological benefit. SL can be carried out safely and effectively. Considering the prevalence of neoadjuvant treatment, the role of SL will become more important.

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Section: Discussionmentioning

confidence: 99%

Role of staging laparoscopy for gastric cancer patients

Fukagawa

2019

Annals of Gastroent Surgery

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“…Epidemiological investigation has demonstrated that the highest morbidity and mortality associated with gastric cancer is found in Asia, especially in China, as the second lethal malignancy. Despite tremendous advances made in both diagnosis and therapeutics over the last decade, the 5‐year survival rate of gastric cancer is still far from satisfactory, which is principally a result of the occurrence of distal metastasis . Meanwhile, sensitive and reliable early diagnostic technology is still missing in clinical practice, which consequently associates with the clinically high frequency of an advanced stage of gastric cancer when pathologically confirmed .…”

Section: Introductionmentioning

confidence: 99%

“…Despite tremendous advances made in both diagnosis and therapeutics over the last decade, the 5‐year survival rate of gastric cancer is still far from satisfactory, which is principally a result of the occurrence of distal metastasis . Meanwhile, sensitive and reliable early diagnostic technology is still missing in clinical practice, which consequently associates with the clinically high frequency of an advanced stage of gastric cancer when pathologically confirmed . The mainstay therapeutic options for this disease include partial surgical resection, chemotherapy and targeted therapies .…”

Section: Introductionmentioning

confidence: 99%

Low abundance of TFPI‐2 by both promoter methylation and miR‐27a‐3p regulation is linked with poor clinical outcome in gastric cancer

Geng

Liu

et al. 2020

The Journal of Gene Medicine

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Background:The tumor suppressor role of tissue factor pathway inhibitor 2 (TFPI-2) has been reported in various tumors. The present study aimed to improve the understanding of the oncogenic properties of TFPI-2 in gastric cancer. Methods:Relative expression of TFPI-2 was determined by a real-time polymerase chain reaction (PCR) and western blotting, respectively. Cell viability was measured via a cell counting kit-8 assay and proliferation was evaluated by a colony formation assay. Cell apoptosis was assessed with a caspase-3 activity kit and invasion was evaluated by a transwell chamber assay. The methylation level of TFPI-2 promoter was assayed by methylation-specific PCR. The regulatory effect of miR-27a-3p on TFPI-2 was analyzed with a luciferase reporter assay. The direct association between miR-27a-3p and TFPI-2 was shown by biotin-labelling pulldown.Results: TFPI-2 was down-regulated in gastric cancer, which associated with an unfavorable prognosis clinically. Ectopic introduction of TFPI-2 greatly compromised cell viability, colony formation and invasive capacity, and also induced cell apoptosis simultaneously. The promoter region of TFPI-2 was extensively methylated in gastric cancer tissues compared to normal tissues, suggesting the epigenetic inhibition of TFPI-2 expression. We further identified that TFPI-2 functioned as sponge RNA against miR-27a-3p. Most importantly, miR-27a-3p-specific inhibitor significantly exerted a tumor suppressor function akin to TFPI-2 itself, and the anti-tumoral activities were completely abolished by TFPI-2 knockdown. Conclusions:We found that the epigenetically suppressed TFPI-2 compromised sponging effects with respect to miR-27a-3p in gastric cancer, which consequently and mechanistically contributed to the tumor biology of gastric cancer. K E Y W O R D Sgastric cancer, methylation, miR-27a-3p, TFPI-2 Geng and Liu contributed equally to this work.

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“…The previous subjective comparisons reflect a particular characteristic, and it is uncertain depending on the subject group. Although the method based on pathological diagnosis is the best standard [14], it costs a lot of time and labor work while it is unreviewable. Therefore, existing methods are not suitable for the generalized research on colorectal images in the testing phase of medical devices.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Comparisons of Linked Color Imaging and White-Light Colonoscopy for Colorectal Polyp Analysis

Wei

Xie

et al. 2018

2018 International Conference on Network Infrastructure and Digital Content (IC-NIDC)

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The performance of imaging techniques has an important influence on the clinical diagnostic strategy of colorectal cancer. Linked color imaging (LCI) by laser endoscopy is a recently developed techniques, and its advantage in improving the analysis accuracy of colorectal polyps over white-light (WL) endoscopy has been demonstrated in previous clinical studies. However, there are no objective criteria to evaluate and compare the aforementioned endoscopy methods. This paper presents a new criterion, namely entropy of color gradients image (ECGI), which is based on color gradients distribution and provides a comprehensive and objective evaluating indicator of the performance of colorectal images. Our method extracts the color gradient image pairs of 143 colonoscopy polyps in the LCI-PairedColon database, which are generated with WL and LCI conditions, respectively. Then, we apply the morphological method to fix the deviation of light-reflecting regions, and the ECGI scores of sample pairs are calculated. Experimental results show that the average ECGI scores of LCI images (5.7071) were significantly higher than that of WL (4.6093). This observation is consistent with the clinical studies. Therefore, the effectiveness of the proposed criterion is demonstrated.

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A prospective multi-institutional validity study to evaluate the accuracy of clinical diagnosis of pathological stage III gastric cancer (JCOG1302A)

Abstract: Clinical diagnosis of T3/T4 tumors was not an optimal criterion to select patients for intensive NAC trials because more than 10% of patients with pathological stage I disease were included. We propose the criterion "cT3/T4 and cN1/N2/N3" instead.

Cited by 114 publications

References 20 publications

Role of staging laparoscopy for gastric cancer patients

Role of staging laparoscopy for gastric cancer patients

Low abundance of TFPI‐2 by both promoter methylation and miR‐27a‐3p regulation is linked with poor clinical outcome in gastric cancer

Quantitative Comparisons of Linked Color Imaging and White-Light Colonoscopy for Colorectal Polyp Analysis

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